TBX1_CAEEL
ID TBX1_CAEEL Reviewed; 252 AA.
AC O17212;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=T-box transcription factor mls-1 {ECO:0000303|PubMed:11799068, ECO:0000303|PubMed:21852953};
DE AltName: Full=Mesodermal lineage specification protein 1 {ECO:0000312|WormBase:H14A12.4};
GN Name=mls-1 {ECO:0000312|WormBase:H14A12.4};
GN ORFNames=H14A12.4 {ECO:0000312|WormBase:H14A12.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP ILE-68.
RX PubMed=11799068; DOI=10.1101/gad.923102;
RA Kostas S.A., Fire A.;
RT "The T-box factor MLS-1 acts as a molecular switch during specification of
RT nonstriated muscle in C. elegans.";
RL Genes Dev. 16:257-269(2002).
RN [3] {ECO:0000305}
RP FUNCTION, INTERACTION WITH UNC-37, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP 5-PHE--ILE-7.
RX PubMed=21852953; DOI=10.1371/journal.pgen.1002210;
RA Miller R.R., Okkema P.G.;
RT "The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-
RT repressor interaction for uterine muscle specification.";
RL PLoS Genet. 7:E1002210-E1002210(2011).
CC -!- FUNCTION: Probable transcription factor required for the cell fate
CC specification of non-striated uterine muscle precursor cells
CC (PubMed:11799068, PubMed:21852953). Furthermore, may function with the
CC transcriptional corepressor unc-37 (PubMed:21852953).
CC {ECO:0000269|PubMed:11799068, ECO:0000269|PubMed:21852953}.
CC -!- SUBUNIT: May interact with unc-37. {ECO:0000269|PubMed:21852953}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DEVELOPMENTAL STAGE: During the larval stage of development, expressed
CC in uterine muscle progenitors and their descendants in the sex myoblast
CC lineage, but only expressed in type 2 vulval muscle precursor cells of
CC the vulval muscle lineage (PubMed:11799068). In larvae, it is also
CC expressed in a subset of enteric muscle cells including the left and
CC right intestinal muscles and the anal depressor muscle
CC (PubMed:11799068, PubMed:21852953). {ECO:0000269|PubMed:11799068,
CC ECO:0000269|PubMed:21852953}.
CC -!- DISRUPTION PHENOTYPE: Non-striated muscle cell fate specification
CC defects whereby the number of vulval cells is doubled and the number of
CC uterine cells is reduced due to the transformation of uterine cells
CC into vulval cells. {ECO:0000269|PubMed:11799068}.
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DR EMBL; BX284603; CCD72344.1; -; Genomic_DNA.
DR PIR; A88508; A88508.
DR RefSeq; NP_498640.1; NM_066239.3.
DR AlphaFoldDB; O17212; -.
DR SMR; O17212; -.
DR STRING; 6239.H14A12.4; -.
DR PaxDb; O17212; -.
DR EnsemblMetazoa; H14A12.4.1; H14A12.4.1; WBGene00003376.
DR GeneID; 186741; -.
DR KEGG; cel:CELE_H14A12.4; -.
DR UCSC; H14A12.4; c. elegans.
DR CTD; 186741; -.
DR WormBase; H14A12.4; CE11584; WBGene00003376; mls-1.
DR eggNOG; KOG3586; Eukaryota.
DR GeneTree; ENSGT00940000155566; -.
DR HOGENOM; CLU_014430_3_0_1; -.
DR InParanoid; O17212; -.
DR OMA; MARIDLK; -.
DR OrthoDB; 1185429at2759; -.
DR PhylomeDB; O17212; -.
DR PRO; PR:O17212; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003376; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0042694; P:muscle cell fate specification; IMP:WormBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0009791; P:post-embryonic development; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..252
FT /note="T-box transcription factor mls-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000438175"
FT DNA_BIND 40..210
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT MUTAGEN 5..7
FT /note="FSI->ASA: Abolishes unc-37 binding."
FT /evidence="ECO:0000269|PubMed:21852953"
FT MUTAGEN 68
FT /note="I->N: In cc571; increased number of vulval cells."
FT /evidence="ECO:0000269|PubMed:11799068"
SQ SEQUENCE 252 AA; 29067 MW; 0DFDB0A9F4F9B130 CRC64;
MNRNFSIDAI LARKPVEKRK QIITKDNCKF IRVFLQSSNL WRRFHNLGTE MIVTKSGRRM
FPTLSVIIAG LDPVKSYVVM VDLECIEMKR FRYSFHQSKW ISTGPGESEL PSRMFVHTDS
PARGAHWMRA PVSFDKMKLT NNQLDNNGHI IVNSMHKYRP RVHIIEQDDS QKRHTFSFEE
TEFIAVTAYQ NHRITSLKIE SNPFAKGFRE CEVQGIEMNS VGGMTGGPAF QSVFPLIFPY
FANLASNMNV NK
