TBX1_XENTR
ID TBX1_XENTR Reviewed; 463 AA.
AC Q3SA49;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=T-box transcription factor TBX1;
DE Short=T-box protein 1;
GN Name=tbx1; ORFNames=TNeu106g11.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=16477648; DOI=10.1002/dvdy.20714;
RA Showell C., Christine K.S., Mandel E.M., Conlon F.L.;
RT "Developmental expression patterns of Tb x 1, Tb x 2, Tb x 5, and Tb x 20
RT in Xenopus tropicalis.";
RL Dev. Dyn. 235:1623-1630(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC processes (By similarity). Binds to the palindromic T site 5'-
CC TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Induces pre-
CC placodal ectoderm (PPE) gene expression in regions where RIPPLY3 is
CC absent. Plays a role in the formation of the anteroposterior (AP) axis
CC during embryonic development; required to establish the posterolateral
CC border of the pre-placodal ectoderm (PPE) acting downstream of the
CC retinoic acid receptor (RAR) signaling (By similarity).
CC {ECO:0000250|UniProtKB:O43435, ECO:0000250|UniProtKB:P70323}.
CC -!- SUBUNIT: Binds DNA as a dimer (By similarity). Interacts with
CC dscr6/ripply3. {ECO:0000250, ECO:0000250|UniProtKB:O43435}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DEVELOPMENTAL STAGE: In early neurulae (stage 13), regionally
CC restricted expression seen in a broad anterior domain surrounding the
CC anterior end of the mediodorsal groove of the neural plate. Within this
CC broad ectodermal domain, expression seen in two bilateral patches
CC flanking the mediodorsal groove. In late neurulae (stage 19), a strong
CC expression is seen in the anterior ectoderm. At early tail bud stage
CC (stage 25), expressed in three distinct areas within the pharyngeal
CC region and in the ventral region of each otic vesicle. At stage 33,
CC expression within the otic vesicles extends further laterally. However,
CC in subsequent stages (stages 40, 47) expression remains restricted to
CC the ventral and lateral regions of the vesicles.
CC {ECO:0000269|PubMed:16477648}.
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DR EMBL; DQ124205; AAZ79650.1; -; mRNA.
DR EMBL; CR926197; CAJ83100.1; -; mRNA.
DR RefSeq; NP_001030290.1; NM_001035118.1.
DR AlphaFoldDB; Q3SA49; -.
DR SMR; Q3SA49; -.
DR STRING; 8364.ENSXETP00000013817; -.
DR PaxDb; Q3SA49; -.
DR GeneID; 619587; -.
DR KEGG; xtr:619587; -.
DR CTD; 6899; -.
DR Xenbase; XB-GENE-478084; tbx1.
DR eggNOG; KOG3586; Eukaryota.
DR HOGENOM; CLU_014430_9_1_1; -.
DR InParanoid; Q3SA49; -.
DR OMA; HHPMNPA; -.
DR OrthoDB; 1185429at2759; -.
DR PhylomeDB; Q3SA49; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000039391; Expressed in neurula embryo and 5 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR GO; GO:0060788; P:ectodermal placode formation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0050793; P:regulation of developmental process; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 2.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..463
FT /note="T-box transcription factor TBX1"
FT /id="PRO_0000262462"
FT DNA_BIND 119..297
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 39..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51143 MW; 96AC5E997091CD3C CRC64;
MISAISSPWL TQLSHFCDVA AFTANSLSSL NASGGYHLSP SPGDPYSQHE PHYEPCSASQ
HSYSFGHACP EPESGASSSS CASSTPGSGS TGSSGSSKAP VKKNPKVANI TVQLEMKALW
DEFNQLGTEM IVTKAGRRMF PTFQVKIFGM DPMADYMLLM DFVPVDDKRY RYAFHSSSWL
VAGKADPATP GRVHYHPDSP AKGAQWMKQI VSFDKLKLTN NLLDDNGHII LNSMHRYQPR
FHVVYVDPRK DSEKYAEENF KTFVFEETRF TAVTAYQNHR ITQLKIASNP FAKGFRDCDP
EDWPRNHRPG SLPLMNAFAR SRNPVSSPPQ NGSDKDGDGR REYERDTSGT PLHGDAAHQQ
LMSRVLSPSL PVPGGLVPLS TGRPSPPHEL RLDPHSQGSE PLHHHPYKYP TSYDHYLGAK
TRPAPYPLPS IRGHGYHHHP MNPAAANMYS GAGAPGSYEY GPR
