TBX20_DANRE
ID TBX20_DANRE Reviewed; 446 AA.
AC Q9I9K7; Q9I8L6;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=T-box transcription factor TBX20;
DE Short=T-box protein 20;
DE AltName: Full=H15-related T-box transcription factor hrT;
GN Name=tbx20;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=10656766; DOI=10.1006/dbio.1999.9571;
RA Griffin K.J.P., Stoller J., Gibson M., Chen S., Yelon D., Stainier D.Y.,
RA Kimelman D.;
RT "A conserved role for H15-related T-box transcription factors in zebrafish
RT and Drosophila heart formation.";
RL Dev. Biol. 218:235-247(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=10906473; DOI=10.1016/s0925-4773(00)00346-4;
RA Ahn D.-G., Ruvinsky I., Oates A.C., Silver L.M., Ho R.K.;
RT "tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons
RT and developing cardiovascular structures in zebrafish.";
RL Mech. Dev. 95:253-258(2000).
CC -!- FUNCTION: Transcriptional regulator that may play a very early role in
CC the differentiation of the cardiac precursors.
CC {ECO:0000269|PubMed:10656766}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DEVELOPMENTAL STAGE: During development, expressed in embryonic
CC structures of both mesodermal and ectodermal origins, including the
CC heart, cranial motor neurons and the roof of the dorsal aorta.
CC Prominently associated with heart formation and continuously expressed
CC in the myocardial lineage from the initiation of myocardial
CC differentiation through to formation of the differentiated, two
CC chambered heart. First detected in anterior lateral plate mesoderm
CC (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM
CC and in two bilateral groups of mesenchymal cells close to the anterior
CC notochord and in a crescent of lateral plate adjacent to the tail. At
CC the 6- to 8- and 12- to 14-somite stages, expressed throughout the
CC ALPM. Between the 10 and 15-somite stages, expressed throughout the
CC myocardium. At the 18-somite stage, expressed in the loosely packed
CC mesenchymal cells in the midline immediately anterior to the heart
CC fields. Later expression seen in the cardiac cone, cardiac tube and
CC ventricle. {ECO:0000269|PubMed:10656766, ECO:0000269|PubMed:10906473}.
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DR EMBL; AF239664; AAF42957.1; -; mRNA.
DR EMBL; AF253325; AAF64322.1; -; mRNA.
DR RefSeq; NP_571581.2; NM_131506.2.
DR AlphaFoldDB; Q9I9K7; -.
DR SMR; Q9I9K7; -.
DR STRING; 7955.ENSDARP00000089658; -.
DR PaxDb; Q9I9K7; -.
DR Ensembl; ENSDART00000017185; ENSDARP00000026669; ENSDARG00000005150.
DR GeneID; 57936; -.
DR KEGG; dre:57936; -.
DR CTD; 57057; -.
DR ZFIN; ZDB-GENE-000427-7; tbx20.
DR eggNOG; KOG3586; Eukaryota.
DR GeneTree; ENSGT00940000158741; -.
DR HOGENOM; CLU_014430_7_1_1; -.
DR InParanoid; Q9I9K7; -.
DR OMA; KEPSENT; -.
DR OrthoDB; 828211at2759; -.
DR PhylomeDB; Q9I9K7; -.
DR PRO; PR:Q9I9K7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000005150; Expressed in ganglionic layer of retina and 36 other tissues.
DR ExpressionAtlas; Q9I9K7; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IMP:ZFIN.
DR GO; GO:0001568; P:blood vessel development; IMP:ZFIN.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IMP:ZFIN.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0035844; P:cloaca development; IMP:ZFIN.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN.
DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
DR GO; GO:0007507; P:heart development; IMP:ZFIN.
DR GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR GO; GO:0003313; P:heart rudiment development; IMP:ZFIN.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:ZFIN.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001570; P:vasculogenesis; IMP:ZFIN.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 2.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..446
FT /note="T-box transcription factor TBX20"
FT /id="PRO_0000262693"
FT DNA_BIND 108..287
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 50..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 96
FT /note="M -> K (in Ref. 2; AAF64322)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="L -> P (in Ref. 2; AAF64322)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="L -> S (in Ref. 2; AAF64322)"
FT /evidence="ECO:0000305"
FT CONFLICT 262..263
FT /note="AV -> CR (in Ref. 2; AAF64322)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="G -> D (in Ref. 2; AAF64322)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 49303 MW; 8E51B49DA37B1244 CRC64;
MEYTSSPKPQ LSSRANAFSI AALMSSGKTK DKESEENTIK PLEQFVEKSS CHPNLGDLPP
LETHSDFSSG GGTGSGAPLC TEPLIPTTPG VPSEEMAKIS CSLETKELWD KFHELGTEMI
ITKSGRRMFP TIRVSFSGVD PDAKYIVLMD IVPVDNKRYR YAYHRSSWLV AGKADPPLPA
RLYVHPDSPF TGEQLLKQMV SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA
SLLNLKSEEF RTFVFTETVF TAVTAYQNQL ITRLKIDSNP FAKGFRDSSR LTDIERESVE
SLIHKHSYAR SPIRTYAGDE ETLGEEGHSA HSRGSAFTAS DNLSLSSWVT TTSGFSGFQH
PQSLSAIGTS TASLASPLPH PIQGSLPPYS RLGMPLTPSA LASSMQATGP TFPSFHMPRY
HHYFQQGPYA AIQGLRHSST VMTPFV
