ID   TBX20_XENLA             Reviewed;         441 AA.
AC   Q8AXW8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=T-box transcription factor TBX20;
DE            Short=T-box protein 20;
GN   Name=tbx20;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=12536325; DOI=10.1007/s00427-002-0276-6;
RA   Brown D.D.W., Binder O., Pagratis M., Parr B.A., Conlon F.L.;
RT   "Developmental expression of the Xenopus laevis Tbx20 orthologue.";
RL   Dev. Genes Evol. 212:604-607(2003).
CC   -!- FUNCTION: Transcriptional regulator that may be involved in heart
CC       developmental processes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- TISSUE SPECIFICITY: Expressed throughout all cardiac tissue during
CC       later stages of development. Also expressed in the cement gland,
CC       jugular vein, lung bud, cloacal aperture, rhombomeres 2, 4, 6 and 8 and
CC       in a subset of motor neurons. {ECO:0000269|PubMed:12536325}.
CC   -!- DEVELOPMENTAL STAGE: First detected at low but consistent levels by
CC       early neural stage (stage 16) with expression then increasing by stage
CC       19 and remaining relatively constant until a sharp drop off at later
CC       neurula stages (stages 23-28). However, there is a sharp increase in
CC       expression between early (stage 30) and mid-tadpole stages.
CC       {ECO:0000269|PubMed:12536325}.
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DR   EMBL; AY154394; AAN39113.1; -; mRNA.
DR   RefSeq; NP_001079332.1; NM_001085863.1.
DR   AlphaFoldDB; Q8AXW8; -.
DR   SMR; Q8AXW8; -.
DR   GeneID; 378656; -.
DR   KEGG; xla:378656; -.
DR   CTD; 378656; -.
DR   Xenbase; XB-GENE-865696; tbx20.L.
DR   OMA; KEPSENT; -.
DR   OrthoDB; 828211at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 378656; Expressed in heart and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000578; P:embryonic axis specification; IMP:BHF-UCL.
DR   GO; GO:0001706; P:endoderm formation; IMP:BHF-UCL.
DR   GO; GO:0007507; P:heart development; IMP:CACAO.
DR   GO; GO:0048370; P:lateral mesoderm formation; IMP:BHF-UCL.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 2.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..441
FT                   /note="T-box transcription factor TBX20"
FT                   /id="PRO_0000262694"
FT   DNA_BIND        103..282
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
SQ   SEQUENCE   441 AA;  48952 MW;  58EC03B20F7565A0 CRC64;
     MEYTPSPKPQ LSSRANAFSI AALMSSGTPK DKEAQESTIK PLEQFVEKSS CSQPIGDISI
     VDSHGEFTNS PSSLCTEPLI PTTPIIPSEE MAKISCSLET KELWDKFHDL GTEMIITKSG
     RRMFPTIRVS FSGVDADAKY IVLMDIVPVD NKRYRYAYHR SAWLVAGKAD PPLPARLYVH
     PDSPFTGEQL LKQMVSFEKV KLTNNELDQH GHIILNSMHK YQPRVHIIKK KDHTASLLNL
     KSEEFRTFIF QETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLTDIE RESVESLIQK
     HSYARSPIRT YGGDEDVLSE DGQVVQCRGS AFTTSDNLSL SSWVSSTSGF SGFQHPQSLT
     ALGTSTASLA TPIPHPIQGS LPPYSRLGMP LTPSALASSM QGSGPTFPSF HMPRYHHYFQ
     QGPYAAIQGL RHSSTVMTPF V