ID   TBX20_XENTR             Reviewed;         440 AA.
AC   Q3SA46;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=T-box transcription factor TBX20;
DE            Short=T-box protein 20;
GN   Name=tbx20;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16477648; DOI=10.1002/dvdy.20714;
RA   Showell C., Christine K.S., Mandel E.M., Conlon F.L.;
RT   "Developmental expression patterns of Tb x 1, Tb x 2, Tb x 5, and Tb x 20
RT   in Xenopus tropicalis.";
RL   Dev. Dyn. 235:1623-1630(2006).
CC   -!- FUNCTION: Transcriptional regulator that may be involved in heart
CC       developmental processes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DEVELOPMENTAL STAGE: At late neurula stage (stage 20), strongly
CC       expressed in the developing cement gland and in the bilateral heart
CC       primordia. Expression in the cement gland decreases from stage 25
CC       onward, while expression continues to be strongly detected in the
CC       developing heart. In the heart-forming region at stage 25, expression
CC       seen in the heart field formed by fusion of the bilateral heart
CC       primordia and also seen in the hindbrain (rhombencephalon) at this
CC       stage, corresponding to the second and fourth rhombomeres. At stage
CC       29/30, expression persists in these regions and also weakly detected in
CC       a more posterior region of the hindbrain. At stage 33, when heart
CC       looping is initiated, broadly expressed in the heart tube, ventricle,
CC       atrium and both branches of the sinus venosus. During heart looping
CC       (stage 36), expressed at a higher level in the atrium than in the
CC       ventricle. {ECO:0000269|PubMed:16477648}.
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DR   EMBL; DQ124208; AAZ79653.1; -; mRNA.
DR   RefSeq; NP_001030292.1; NM_001035120.1.
DR   AlphaFoldDB; Q3SA46; -.
DR   SMR; Q3SA46; -.
DR   PaxDb; Q3SA46; -.
DR   Ensembl; ENSXETT00000028708; ENSXETP00000028708; ENSXETG00000013110.
DR   GeneID; 619590; -.
DR   KEGG; xtr:619590; -.
DR   CTD; 57057; -.
DR   Xenbase; XB-GENE-487334; tbx20.
DR   eggNOG; KOG3586; Eukaryota.
DR   HOGENOM; CLU_014430_7_1_1; -.
DR   InParanoid; Q3SA46; -.
DR   OMA; HMANISC; -.
DR   OrthoDB; 828211at2759; -.
DR   PhylomeDB; Q3SA46; -.
DR   TreeFam; TF106341; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013110; Expressed in heart and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 2.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..440
FT                   /note="T-box transcription factor TBX20"
FT                   /id="PRO_0000262695"
FT   DNA_BIND        103..282
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
SQ   SEQUENCE   440 AA;  48912 MW;  B18A63D173A74560 CRC64;
     MEYTPSPKPQ LSSRANAFSI AALMSSGTPK DKETQESTIK PLEQFVEKSS CSQPLGDISI
     VDSHGEFTNS PSSLCTEPLI PTTPVIPSEE MAKISCSLET KELWDKFHDL GTEMIITKSG
     RRMFPTIRVS FSGVDADAKY IVLMDIVPVD NKRYRYAYHR SSWLVAGKAD PPLPARLYVH
     PDSPFTGEQL LKQMVSFEKV KLTNNELDQH GHIILNSMHK YQPRVHIIKK KDHTASLLNL
     KSEEFRTFIF QETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLTDIE RESVESLIQK
     HSYARSPIRT YGDEDVLGED GQTMQSRGSA FTTSENLSLS SWVSSTSGFS GFQHPQSLTA
     LGTSTASLAT PIPHPIQGTL PPYSRLGMPI TPSALASSMQ GSGPTFPSFH MPRYHHYFQQ
     GPYAAIQGLR HSSAVMTPFV