TBX22_MOUSE
ID TBX22_MOUSE Reviewed; 517 AA.
AC Q8K402;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=T-box transcription factor TBX22;
DE Short=T-box protein 22;
GN Name=Tbx22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12374769; DOI=10.1093/hmg/11.22.2793;
RA Braybrook C., Lisgo S., Doudney K., Henderson D., Marcano A.C.B.,
RA Strachan T., Patton M.A., Villard L., Moore G.E., Stanier P., Lindsay S.;
RT "Craniofacial expression of human and murine TBX22 correlates with the
RT cleft palate and ankyloglossia phenotype observed in CPX patients.";
RL Hum. Mol. Genet. 11:2793-2804(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J;
RX PubMed=12412015; DOI=10.1002/dvdy.10154;
RA Bush J.O., Lan Y., Maltby K.M., Jiang R.;
RT "Isolation and developmental expression analysis of Tbx22, the mouse
RT homolog of the human X-linked cleft palate gene.";
RL Dev. Dyn. 225:322-326(2002).
CC -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC processes. This is major determinant crucial to palatogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DEVELOPMENTAL STAGE: Expressed in a temporally and spatially highly
CC restricted pattern during mouse palate and tongue development.
CC {ECO:0000269|PubMed:12412015}.
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DR EMBL; AF516208; AAM64167.1; -; mRNA.
DR EMBL; AY125891; AAM94354.1; -; mRNA.
DR CCDS; CCDS30350.1; -.
DR RefSeq; NP_001277676.1; NM_001290747.1.
DR RefSeq; NP_660259.1; NM_145224.3.
DR RefSeq; NP_851836.2; NM_181319.5.
DR RefSeq; XP_017173980.1; XM_017318491.1.
DR AlphaFoldDB; Q8K402; -.
DR SMR; Q8K402; -.
DR STRING; 10090.ENSMUSP00000128247; -.
DR PhosphoSitePlus; Q8K402; -.
DR PaxDb; Q8K402; -.
DR PRIDE; Q8K402; -.
DR ProteomicsDB; 263258; -.
DR Antibodypedia; 510; 215 antibodies from 28 providers.
DR DNASU; 245572; -.
DR Ensembl; ENSMUST00000118986; ENSMUSP00000112544; ENSMUSG00000031241.
DR GeneID; 245572; -.
DR KEGG; mmu:245572; -.
DR UCSC; uc012hnt.2; mouse.
DR CTD; 50945; -.
DR MGI; MGI:2389465; Tbx22.
DR VEuPathDB; HostDB:ENSMUSG00000031241; -.
DR eggNOG; KOG3586; Eukaryota.
DR GeneTree; ENSGT00940000161206; -.
DR HOGENOM; CLU_030727_1_0_1; -.
DR InParanoid; Q8K402; -.
DR OrthoDB; 828211at2759; -.
DR PhylomeDB; Q8K402; -.
DR BioGRID-ORCS; 245572; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8K402; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8K402; protein.
DR Bgee; ENSMUSG00000031241; Expressed in secondary palatal shelf mesenchyme and 46 other tissues.
DR ExpressionAtlas; Q8K402; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..517
FT /note="T-box transcription factor TBX22"
FT /id="PRO_0000184456"
FT DNA_BIND 93..280
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 58498 MW; C2B7C4F813BA4B5E CRC64;
MALSSRAHAF SVEALMGRPS KRKAQDPREE MQPELQEEQF VEEGEEILRS PSRDSQQPEK
RLKAESSKTV FSCSDESNSQ ESLQEESVIQ VELQGSDLWK RFHDIGTEMI ITKAGRRMFP
SVRIKVKGMD PVKQYYVILD VVPVDSKRYR YVYHSSQWMV AGNTDHSCIT PRFYVHPDSP
CSGENWMRQI ISFDRVKLTN NEMDDKGHII LQSMHKYNPR VHVVEQDSRI DLSLIESFPT
EGVKTFSFKE TEFTTVTAYQ NQQITKLKID RNPFAKGFRD PGRNRGVLDG FLETYPWMPS
FSMDFKTFVT DTQSGSSGSS PVTSSGGAPS PLNSLLSPSC SPPMVYIPPS SFGMTYPDAY
LHSVNIPFCY RICPTNNWRS QPFVLPTPER LPSFIIPQTL PPLMMEVPVV SSRGIINPNS
GLHEDCNGQC LQASHSANQM LYGLQNPGNI FHPNAIAQEA ISYPFHPPNG CYRYTISMPP
RLENVASHLS ENGTSQISFT EGSCDHSHWY PAINHYL
