TBX2A_XENLA
ID TBX2A_XENLA Reviewed; 688 AA.
AC Q9IBC8; Q9W7R7;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=T-box transcription factor TBX2-A;
DE Short=T-box protein 2-A;
GN Name=tbx2-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=10552304; DOI=10.1007/s004270050297;
RA Hayata T., Kuroda H., Eisaki A., Asashima M.;
RT "Expression of Xenopus T-box transcription factor, tbx2 in Xenopus
RT embryo.";
RL Dev. Genes Evol. 209:625-628(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=10704879; DOI=10.1016/s0925-4773(99)00329-9;
RA Takabatake Y., Takabatake T., Takeshima K.;
RT "Conserved and divergent expression of T-box genes Tbx2-Tbx5 in Xenopus.";
RL Mech. Dev. 91:433-437(2000).
CC -!- FUNCTION: Transcription factor which acts as a transcriptional
CC repressor (By similarity). May also function as a transcriptional
CC activator (By similarity). Binds to the palindromic T site 5'-
CC TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present
CC in the regulatory region of several genes (By similarity).
CC {ECO:0000250|UniProtKB:Q13207, ECO:0000250|UniProtKB:Q60707}.
CC -!- SUBUNIT: Binds DNA as a monomer. {ECO:0000250|UniProtKB:Q13207}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13207}.
CC -!- DEVELOPMENTAL STAGE: First detected in the ventral mesodermal cells
CC just above the yolk plug at late gastrula. At the neurula stage,
CC strongly expressed in the cement gland, dorsal root ganglia and otic
CC vesicle region. At the tailbud stage, a strong expression is observed
CC in the dorsal part of the optic cup and trigeminal ganglia, and it is
CC also expressed in the branchial arches, heart anlage, nasal pit,
CC proctodeum and the region around the pronephros.
CC {ECO:0000269|PubMed:10552304, ECO:0000269|PubMed:10704879}.
CC -!- DOMAIN: Repression domain 1 (RD1) is involved in transcriptional
CC repression. {ECO:0000250|UniProtKB:Q13207}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA82338.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA93081.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB023815; BAA82338.1; ALT_INIT; mRNA.
DR EMBL; AB032941; BAA93081.1; ALT_INIT; mRNA.
DR RefSeq; NP_001081374.1; NM_001087905.1.
DR AlphaFoldDB; Q9IBC8; -.
DR SMR; Q9IBC8; -.
DR BioGRID; 99140; 3.
DR GeneID; 397801; -.
DR KEGG; xla:397801; -.
DR CTD; 397801; -.
DR Xenbase; XB-GENE-1018122; tbx2.L.
DR OMA; HQDERCT; -.
DR OrthoDB; 301173at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 397801; Expressed in internal ear and 15 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..688
FT /note="T-box transcription factor TBX2-A"
FT /id="PRO_0000262464"
FT DNA_BIND 104..277
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 301..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 655..679
FT /evidence="ECO:0000255"
FT COMPBIAS 336..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 221..222
FT /note="QP -> HA (in Ref. 1; BAA82338)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 688 AA; 75225 MW; 4CE98A539F3DC646 CRC64;
MRDPAFPGAA MAYHPFHAPR AADFPMSAFL AAAQPSFFPA LTLPPAALGK PLSDASLAGA
AEAGLHLSAL GHHHQAAHLR SLKSLEPEEE VEDDPKVNLE AKELWDQFHK IGTEMVITKS
GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP
DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLS LPSLRMYEEQ
CKADRDGAES DASSCDPAPG RDSLHSPLSA EPSPLRLHRN NREEKFGADS DQELDRREIR
SARSHSPVGH RSPPSSPRLE DRGKDKSTPE KKSDSPESRK DGSDSLFSSI RSLEKDKAES
RRKEDSKSDP ECGSLSKETF APLMVQTDSP PHLSASHLQS LALSGLHGQQ FFNPLNAGQP
LFIHPGQFTM GPGAFSAMGM GHLLASMTGA GALDNGSLSS VQGATGAANP FPFHFSQHML
ASQGIPMPAF GGLFPYPYTY MAAAAAAASA MPATSAATTM PRNPFLSSTR PRLRFNPYQI
PVGIPPSTNL LTTGLPGSLN PGSESSKPGS SRESSPIPDT PVPKRSHSNS LSPKASMKDS
INELQNIQRL VSGLESQREI SPGRETPK
