ID   TBX2B_XENLA             Reviewed;         691 AA.
AC   Q6PCL0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=T-box transcription factor TBX2-B;
DE            Short=T-box protein 2-B;
GN   Name=tbx2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which acts as a transcriptional
CC       repressor (By similarity). May also function as a transcriptional
CC       activator (By similarity). Binds to the palindromic T site 5'-
CC       TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present
CC       in the regulatory region of several genes (By similarity).
CC       {ECO:0000250|UniProtKB:Q13207, ECO:0000250|UniProtKB:Q60707}.
CC   -!- SUBUNIT: Binds DNA as a monomer. {ECO:0000250|UniProtKB:Q13207}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13207}.
CC   -!- DOMAIN: Repression domain 1 (RD1) is involved in transcriptional
CC       repression. {ECO:0000250|UniProtKB:Q13207}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH59285.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC059285; AAH59285.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001079989.1; NM_001086520.1.
DR   AlphaFoldDB; Q6PCL0; -.
DR   SMR; Q6PCL0; -.
DR   DNASU; 379680; -.
DR   GeneID; 379680; -.
DR   KEGG; xla:379680; -.
DR   CTD; 379680; -.
DR   Xenbase; XB-GENE-6255176; tbx2.S.
DR   OrthoDB; 301173at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 379680; Expressed in internal ear and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR022582; TBX2/3_TAD.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   Pfam; PF12598; TBX; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..691
FT                   /note="T-box transcription factor TBX2-B"
FT                   /id="PRO_0000262465"
FT   DNA_BIND        104..277
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          301..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          612..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          659..684
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        337..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..401
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..435
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..640
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..670
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  75565 MW;  965BD4B5CEFE0C23 CRC64;
     MRDPAFPGAA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LTLPPAALGK PLSDPSLAGA
     AEAGLHLSAL GHHHQAAHLR SLKSLEPEEE VDDDPKVNLE AKELWDQFHK IGTEMVITKS
     GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP
     DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
     RTYVFPETDF IAVTAYQNDK ITQLKIDHNP FAKGFRDTGN GRREKRKQLS LPSLRMYEEQ
     CKADRDGAES DASSCDPAPG RDSLHSPLSA APSPLRLHRT NREEKFGADS DQELDRREVR
     SARGHSPVGH RSPPSSPRLE DRGKDKSTPE KKSDSPESRK DGGSGGDSLF NSIRSLEKDK
     VESRRKEDSK SDPECGSLSK ETYSPLMVQT ESPPHLSASH LQSLAFSGLH GQQFFNPLNA
     GQPLFFHPGQ FTMGPGAFSA MGMGHLLASM TGAGALDNGS LSSVQGASGA ATPFPFHLSQ
     HMLASQGIPM PAFGGLFPYP YTYMAAAAAA ASAMPATSAA TTMPRNPFLS STRPRLRFNP
     YQIPVGIPPC SNLLTTGMPG SINPGSESSK PGSSRESSPI PDTPGHKRSH SKSLSPKASM
     KDSINELQRI QRLVSGLERQ REVSPGRESP K