ID   TBX2_XENTR              Reviewed;         685 AA.
AC   Q3SA48; A4IGQ9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=T-box transcription factor TBX2;
DE            Short=T-box protein 2;
GN   Name=tbx2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16477648; DOI=10.1002/dvdy.20714;
RA   Showell C., Christine K.S., Mandel E.M., Conlon F.L.;
RT   "Developmental expression patterns of Tb x 1, Tb x 2, Tb x 5, and Tb x 20
RT   in Xenopus tropicalis.";
RL   Dev. Dyn. 235:1623-1630(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which acts as a transcriptional
CC       repressor (By similarity). May also function as a transcriptional
CC       activator (By similarity). Binds to the palindromic T site 5'-
CC       TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present
CC       in the regulatory region of several genes (By similarity).
CC       {ECO:0000250|UniProtKB:Q13207, ECO:0000250|UniProtKB:Q60707}.
CC   -!- SUBUNIT: Binds DNA as a monomer. {ECO:0000250|UniProtKB:Q13207}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13207}.
CC   -!- DEVELOPMENTAL STAGE: Expressed ventrally in early gastrulae (stage
CC       10.5) and is expressed most strongly in the outer layer of ectodermal
CC       cells. At the late gastrula stage (stage 12), expression appears to be
CC       up-regulated consistently in a small group of cells clustered around
CC       the ventral edge of the closing blastopore. At the early neurula stage
CC       (stage 13), four regions of ectodermal expression are clearly detected.
CC       At stage 19 (late neurula), expression persists in the cement gland,
CC       the ventral epidermis, the proctodeal region, the lens placodes, and in
CC       a broad placodal area caudal to the eye anlagen. In addition,
CC       expression also detected in the dorsal root ganglia of the future
CC       spinal cord. At stage 21/22, expression seen in a wishbone-shaped group
CC       of cells situated dorsal and caudal to each developing optic vesicle
CC       corresponding to the cranial (profundal and trigeminal) ganglia.
CC       Expression persists in these cells through tail bud and into early
CC       tadpole stages. From stage 21/22 onward, the bilateral expression in
CC       the ectodermal placodes becomes restricted primarily to the otic
CC       placode and the developing otic vesicles. At stage 24, also observed in
CC       the precursors of the hypaxial muscles and the pronephric duct in the
CC       trunk, in the developing branchial arches and in the primordium of the
CC       heart. In stage 29 embryos, expression detected in the frontonasal
CC       process and continues to be expressed in the same regions of the embryo
CC       at stage 33, although its expression becomes clearly regionalized in
CC       the looping heart. A higher level of expression seen in the ventricle
CC       as compared with the atrium. {ECO:0000269|PubMed:16477648}.
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DR   EMBL; DQ124206; AAZ79651.1; -; mRNA.
DR   EMBL; BC135209; AAI35210.1; -; mRNA.
DR   RefSeq; NP_001030291.1; NM_001035119.1.
DR   RefSeq; XP_017946799.1; XM_018091310.1.
DR   AlphaFoldDB; Q3SA48; -.
DR   SMR; Q3SA48; -.
DR   PaxDb; Q3SA48; -.
DR   PRIDE; Q3SA48; -.
DR   DNASU; 619588; -.
DR   Ensembl; ENSXETT00000044410; ENSXETP00000044410; ENSXETG00000020557.
DR   GeneID; 619588; -.
DR   KEGG; xtr:619588; -.
DR   CTD; 6909; -.
DR   Xenbase; XB-GENE-1018115; tbx2.
DR   eggNOG; KOG3585; Eukaryota.
DR   HOGENOM; CLU_023038_1_0_1; -.
DR   InParanoid; Q3SA48; -.
DR   OMA; PWCEDRV; -.
DR   OrthoDB; 301173at2759; -.
DR   PhylomeDB; Q3SA48; -.
DR   TreeFam; TF106341; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020557; Expressed in hypaxial musculature and 24 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR022582; TBX2/3_TAD.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   Pfam; PF12598; TBX; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..685
FT                   /note="T-box transcription factor TBX2"
FT                   /id="PRO_0000262466"
FT   DNA_BIND        104..277
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          270..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          652..676
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        277..311
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..430
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  74951 MW;  C00BBEF198085A0C CRC64;
     MRDPAFPGAA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LTLPPAALGK PLSDPSLAGA
     AEAGLHVSAL GHHHQAAHLR SLKSLEPEEE VEDDPKVTLE AKELWDQFHK LGTEMVITKS
     GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP
     DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
     RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLS LPSLRMYEEQ
     CKADRDGAES DASSCDPAPG RDSLHSPLST EPSPLRLHRS NREEKFGADS DQELDRREVR
     TARSHSPVGH RSPPSSPRLE DRGKDKNTPE KKSESPESRK DGGDNVFSRS LEKDKGESRR
     KEDSKSDPEC GSLSKETFAP LMVQTDSPPH LSASHLQSLA LSGLHGQQFF NPLNAAQPLF
     IHPGQFTMGP GAFSAMGMGH LLASMTGASA LDNGSLSSVQ GATGAATFPF HLSQHMLASQ
     GIPMPAFGGL FPYPYTYMAA AAAAASAMPA TSAATTMPRN PFLSSTRPRL RFNPYQIPVG
     IPPSTNLLTT GLSASLNPGS ESSKPGSSRE SSPIPDTPGH KRSHSNSLSP KASMKDSINE
     LQNIQRLVSG LESQREVSPG RETPK