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TBX30_CAEEL
ID   TBX30_CAEEL             Reviewed;         308 AA.
AC   Q9N2K7;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Putative T-box protein 30/42;
GN   Name=tbx-30; ORFNames=Y59E9AR.3;
GN   and
GN   Name=tbx-42; ORFNames=Y59E9AR.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=15102704; DOI=10.1242/dev.01110;
RA   Pocock R., Ahringer J., Mitsch M., Maxwell S., Woollard A.;
RT   "A regulatory network of T-box genes and the even-skipped homologue vab-7
RT   controls patterning and morphogenesis in C. elegans.";
RL   Development 131:2373-2385(2004).
CC   -!- FUNCTION: Involved in the regulatory network to control embryonic
CC       patterning and morphogenesis. Implicated in negatively regulating vab-7
CC       expression at the anterior of embryos. {ECO:0000269|PubMed:15102704}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DISRUPTION PHENOTYPE: Alters embryonic vab-7 expression pattern.
CC       {ECO:0000269|PubMed:15102704}.
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DR   EMBL; FO081311; CCD70691.1; -; Genomic_DNA.
DR   EMBL; FO081311; CCD70693.1; -; Genomic_DNA.
DR   RefSeq; NP_500749.1; NM_068348.1.
DR   RefSeq; NP_500750.1; NM_068349.1.
DR   AlphaFoldDB; Q9N2K7; -.
DR   SMR; Q9N2K7; -.
DR   BioGRID; 55006; 5.
DR   DIP; DIP-24914N; -.
DR   IntAct; Q9N2K7; 5.
DR   STRING; 6239.Y59E9AR.3; -.
DR   EPD; Q9N2K7; -.
DR   PaxDb; Q9N2K7; -.
DR   EnsemblMetazoa; Y59E9AR.3.1; Y59E9AR.3.1; WBGene00006549.
DR   EnsemblMetazoa; Y59E9AR.5.1; Y59E9AR.5.1; WBGene00022000.
DR   GeneID; 190419; -.
DR   GeneID; 190421; -.
DR   KEGG; cel:CELE_Y59E9AR.3; -.
DR   KEGG; cel:CELE_Y59E9AR.5; -.
DR   UCSC; Y59E9AR.5; c. elegans.
DR   CTD; 190419; -.
DR   CTD; 190421; -.
DR   WormBase; Y59E9AR.3; CE25515; WBGene00006549; tbx-30.
DR   WormBase; Y59E9AR.5; CE25515; WBGene00022000; tbx-42.
DR   eggNOG; KOG3585; Eukaryota.
DR   GeneTree; ENSGT00970000196896; -.
DR   HOGENOM; CLU_728115_0_0_1; -.
DR   InParanoid; Q9N2K7; -.
DR   OMA; SCKILLI; -.
DR   OrthoDB; 1809882at2759; -.
DR   PhylomeDB; Q9N2K7; -.
DR   Reactome; R-CEL-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR   PRO; PR:Q9N2K7; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006549; Expressed in embryo and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..308
FT                   /note="Putative T-box protein 30/42"
FT                   /id="PRO_0000184476"
FT   DNA_BIND        11..192
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          186..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  35819 MW;  97A36E5785D8B4B7 CRC64;
     MNPSTQIVVK MSNEELWKER YPNMEMISNS KRITPIFPEI KFKISGLEEN SRYVLVLSLE
     KMDNIRYGIN ENKEWAPSSA RKPKPHHNMK FFFHPEGTKL GKELMAETVE FTSVRITTSE
     KLSEKENVFY VHTMHKYVPV LTIRNLTTGE IASNIFKMEI AQFFPVSIYQ QASMGRWKSD
     LNKHSTFGNR SEGGIKRKTS DAAGQLPSKR SSKKPVKKDV VDNSEVTLEV KTSQYLVNQN
     ESNLTEYIPS SPLYSSQNQY QYPFHPYSPF DSSIPYPYSP MDYSYYFNPT FQSFSPENVY
     FDENRNPH
 
 
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