TBX35_CAEEL
ID TBX35_CAEEL Reviewed; 325 AA.
AC Q09376;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=T-box transcription factor tbx-35 {ECO:0000303|PubMed:19605496};
GN Name=tbx-35; ORFNames=ZK177.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19605496; DOI=10.1242/dev.038307;
RA Broitman-Maduro G., Owraghi M., Hung W.W., Kuntz S., Sternberg P.W.,
RA Maduro M.F.;
RT "The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have
RT overlapping function in C. elegans mesoderm development.";
RL Development 136:2735-2746(2009).
CC -!- FUNCTION: Transcription factor which plays a role in mesoderm
CC development, probably by regulating expression of target genes, such as
CC homeobox protein ceh-51 (PubMed:19605496). Binds to DNA consensus motif
CC 5'-[AG]T[GC][GT]CACC[TC][AGCT][AGCT][CT][CT]-3' in promoter elements
CC (PubMed:19605496). {ECO:0000269|PubMed:19605496}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DISRUPTION PHENOTYPE: Knockout causes abnormal development of the
CC pharynx, when cultured at the restrictive temperature of 23 degrees
CC Celsius, which is exacerbated on a ceh-51 mutant background
CC (PubMed:19605496). Embryonic arrest occurs on a ceh-51 mutant
CC background (PubMed:19605496). Expression of homeodomain protein ceh-51
CC in embryo is reduced; abolished by simultaneous RNAi-mediated knockdown
CC of pop-1 (PubMed:19605496). {ECO:0000269|PubMed:19605496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080583; CCD64863.1; -; Genomic_DNA.
DR PIR; T27769; T27769.
DR RefSeq; NP_495059.2; NM_062658.2.
DR AlphaFoldDB; Q09376; -.
DR SMR; Q09376; -.
DR STRING; 6239.ZK177.10; -.
DR PaxDb; Q09376; -.
DR PRIDE; Q09376; -.
DR EnsemblMetazoa; ZK177.10.1; ZK177.10.1; WBGene00006554.
DR GeneID; 191239; -.
DR KEGG; cel:CELE_ZK177.10; -.
DR UCSC; ZK177.10; c. elegans.
DR CTD; 191239; -.
DR WormBase; ZK177.10; CE40000; WBGene00006554; tbx-35.
DR eggNOG; KOG3585; Eukaryota.
DR HOGENOM; CLU_855880_0_0_1; -.
DR InParanoid; Q09376; -.
DR OMA; PITHRPE; -.
DR OrthoDB; 1840964at2759; -.
DR PhylomeDB; Q09376; -.
DR Reactome; R-CEL-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR PRO; PR:Q09376; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00006554; Expressed in embryo.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0007501; P:mesodermal cell fate specification; IMP:WormBase.
DR GO; GO:0042694; P:muscle cell fate specification; IGI:WormBase.
DR GO; GO:0043282; P:pharyngeal muscle development; IGI:WormBase.
DR GO; GO:0060465; P:pharynx development; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..325
FT /note="T-box transcription factor tbx-35"
FT /id="PRO_0000184480"
FT DNA_BIND 32..210
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 204..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 37900 MW; 6C30AA90AABFD6BA CRC64;
MSFNYSMNTP SPSMLSFDMD IPITAFLHNS DVFQLFHPDI MEQVVVNKER VFFPTPSFNV
LNLESDCLYK MSLRFDKTNN KRFQFNRQTK QWTEYDKVSN HKESEVFVHP SEIRTGDDWM
KSPVEFFIKV TNLRSSESDE VICLESQCKY QPTLLIQKVF RDCFGCFQAH GPPVEIKFAL
LTFIATTRYC SRRIADIKSS LNPFSSQDTK KKNKRNTLKA VSQEENQPIE NSSFHQSFSN
QYLSKPDLDL KSTTLLQIAP DHSFEPTNFV SSSHFPCWDS IFCQQSFPTP SSSPYSDSLP
HFTNEWNTPT FYNENFMSYP NFPNY