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TBX35_CAEEL
ID   TBX35_CAEEL             Reviewed;         325 AA.
AC   Q09376;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=T-box transcription factor tbx-35 {ECO:0000303|PubMed:19605496};
GN   Name=tbx-35; ORFNames=ZK177.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19605496; DOI=10.1242/dev.038307;
RA   Broitman-Maduro G., Owraghi M., Hung W.W., Kuntz S., Sternberg P.W.,
RA   Maduro M.F.;
RT   "The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have
RT   overlapping function in C. elegans mesoderm development.";
RL   Development 136:2735-2746(2009).
CC   -!- FUNCTION: Transcription factor which plays a role in mesoderm
CC       development, probably by regulating expression of target genes, such as
CC       homeobox protein ceh-51 (PubMed:19605496). Binds to DNA consensus motif
CC       5'-[AG]T[GC][GT]CACC[TC][AGCT][AGCT][CT][CT]-3' in promoter elements
CC       (PubMed:19605496). {ECO:0000269|PubMed:19605496}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DISRUPTION PHENOTYPE: Knockout causes abnormal development of the
CC       pharynx, when cultured at the restrictive temperature of 23 degrees
CC       Celsius, which is exacerbated on a ceh-51 mutant background
CC       (PubMed:19605496). Embryonic arrest occurs on a ceh-51 mutant
CC       background (PubMed:19605496). Expression of homeodomain protein ceh-51
CC       in embryo is reduced; abolished by simultaneous RNAi-mediated knockdown
CC       of pop-1 (PubMed:19605496). {ECO:0000269|PubMed:19605496}.
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DR   EMBL; FO080583; CCD64863.1; -; Genomic_DNA.
DR   PIR; T27769; T27769.
DR   RefSeq; NP_495059.2; NM_062658.2.
DR   AlphaFoldDB; Q09376; -.
DR   SMR; Q09376; -.
DR   STRING; 6239.ZK177.10; -.
DR   PaxDb; Q09376; -.
DR   PRIDE; Q09376; -.
DR   EnsemblMetazoa; ZK177.10.1; ZK177.10.1; WBGene00006554.
DR   GeneID; 191239; -.
DR   KEGG; cel:CELE_ZK177.10; -.
DR   UCSC; ZK177.10; c. elegans.
DR   CTD; 191239; -.
DR   WormBase; ZK177.10; CE40000; WBGene00006554; tbx-35.
DR   eggNOG; KOG3585; Eukaryota.
DR   HOGENOM; CLU_855880_0_0_1; -.
DR   InParanoid; Q09376; -.
DR   OMA; PITHRPE; -.
DR   OrthoDB; 1840964at2759; -.
DR   PhylomeDB; Q09376; -.
DR   Reactome; R-CEL-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR   PRO; PR:Q09376; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00006554; Expressed in embryo.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0007501; P:mesodermal cell fate specification; IMP:WormBase.
DR   GO; GO:0042694; P:muscle cell fate specification; IGI:WormBase.
DR   GO; GO:0043282; P:pharyngeal muscle development; IGI:WormBase.
DR   GO; GO:0060465; P:pharynx development; IMP:WormBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..325
FT                   /note="T-box transcription factor tbx-35"
FT                   /id="PRO_0000184480"
FT   DNA_BIND        32..210
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          204..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  37900 MW;  6C30AA90AABFD6BA CRC64;
     MSFNYSMNTP SPSMLSFDMD IPITAFLHNS DVFQLFHPDI MEQVVVNKER VFFPTPSFNV
     LNLESDCLYK MSLRFDKTNN KRFQFNRQTK QWTEYDKVSN HKESEVFVHP SEIRTGDDWM
     KSPVEFFIKV TNLRSSESDE VICLESQCKY QPTLLIQKVF RDCFGCFQAH GPPVEIKFAL
     LTFIATTRYC SRRIADIKSS LNPFSSQDTK KKNKRNTLKA VSQEENQPIE NSSFHQSFSN
     QYLSKPDLDL KSTTLLQIAP DHSFEPTNFV SSSHFPCWDS IFCQQSFPTP SSSPYSDSLP
     HFTNEWNTPT FYNENFMSYP NFPNY
 
 
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