TBX3_CHICK
ID TBX3_CHICK Reviewed; 414 AA.
AC O73718;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=T-box transcription factor TBX3;
DE Short=T-box protein 3;
DE Flags: Fragment;
GN Name=TBX3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9550719; DOI=10.1242/dev.125.10.1867;
RA Issac A., Rodriguez-Esteban C., Ryan A., Altabef M., Tsukui T., Patel K.,
RA Tickle C., Izpisua-Belmonte J.-C.;
RT "Tbx genes and limb identity in chick embryo development.";
RL Development 125:1867-1875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 114-295.
RX PubMed=9655805; DOI=10.1242/dev.125.15.2825;
RA Logan M., Simon H.-G., Tabin C.;
RT "Differential regulation of T-box and homeobox transcription factors
RT suggests roles in controlling chick limb-type identity.";
RL Development 125:2825-2835(1998).
CC -!- FUNCTION: Transcriptional repressor involved in developmental
CC processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA
CC sequence, or a half-site, which are present in the regulatory region of
CC several genes. Probably plays a role in limb pattern formation.
CC {ECO:0000250|UniProtKB:O15119}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR EMBL; AF033669; AAC41297.1; -; mRNA.
DR EMBL; AF069394; AAC23681.1; -; mRNA.
DR STRING; 9031.ENSGALP00000013415; -.
DR PaxDb; O73718; -.
DR PRIDE; O73718; -.
DR VEuPathDB; HostDB:geneid_374202; -.
DR eggNOG; KOG3585; Eukaryota.
DR InParanoid; O73718; -.
DR PhylomeDB; O73718; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; ISS:UniProtKB.
DR GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; ISS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISS:UniProtKB.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISS:UniProtKB.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0046884; P:follicle-stimulating hormone secretion; ISS:UniProtKB.
DR GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR GO; GO:0032275; P:luteinizing hormone secretion; ISS:UniProtKB.
DR GO; GO:0030539; P:male genitalia development; ISS:UniProtKB.
DR GO; GO:0048332; P:mesoderm morphogenesis; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; ISS:UniProtKB.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..>414
FT /note="T-box transcription factor TBX3"
FT /id="PRO_0000184431"
FT DNA_BIND 114..287
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 347..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 414
SQ SEQUENCE 414 AA; 46425 MW; 2F81E2DF3C4BB6C6 CRC64;
MNIPMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALALPPNG AAALSLPGAL
AKPIMDQLVG AAETAIPFSS LGQQAAAHLR PLKTLEPEEE VEDDPKVHLE AKELWEQFHK
RGTEMVITKS GRRMFPPFKV RCTGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP
EMPKRMYIHP DSPATGEQWM SKVVTFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN
DILKLPYSTF RTYVFPETEF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT
LQSMRVYDER QKKENPTSDE SSNEQTAFKC FAQSSCPAVP AVGTSSFKDL CPGEVDRDXD
SXDDXXLEXS EWGKISTTTX THPWXQPAXG RQRVTTXGTK GAAVPKATSS PXTR
