TBX3_MOUSE
ID TBX3_MOUSE Reviewed; 741 AA.
AC P70324; E9QM97; Q60708; Q8BWH7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=T-box transcription factor TBX3;
DE Short=T-box protein 3;
GN Name=Tbx3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 112-313 (ISOFORM 2).
RC TISSUE=Embryo;
RX PubMed=8878690; DOI=10.1093/genetics/144.1.249;
RA Agulnik S.I., Garvey N., Hancock S., Ruvinsky I., Chapman D.L., Agulnik I.,
RA Bollag R.J., Papaioannou V.E., Silver L.M.;
RT "Evolution of mouse T-box genes by tandem duplication and cluster
RT dispersion.";
RL Genetics 144:249-254(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 185-286 (ISOFORM 2).
RC TISSUE=Embryo;
RX PubMed=7920656; DOI=10.1038/ng0794-383;
RA Bollag R.J., Siegfried Z., Cebra-Thomas J.A., Garvey N., Davison E.M.,
RA Silver L.M.;
RT "An ancient family of embryonically expressed mouse genes sharing a
RT conserved protein motif with the T locus.";
RL Nat. Genet. 7:383-389(1994).
RN [5]
RP DEVELOPMENTAL STAGE.
RX PubMed=8853987;
RX DOI=10.1002/(sici)1097-0177(199608)206:4<379::aid-aja4>3.0.co;2-f;
RA Chapman D.L., Garvey N., Hancock S., Alexiou M., Agulnik S.I.,
RA Gibson-Brown J.J., Cebra-Thomas J., Bollag R.J., Silver L.M.,
RA Papaioannou V.E.;
RT "Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
RT development.";
RL Dev. Dyn. 206:379-390(1996).
RN [6]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16222716; DOI=10.1002/dvdy.20575;
RA Jerome-Majewska L.A., Jenkins G.P., Ernstoff E., Zindy F., Sherr C.J.,
RA Papaioannou V.E.;
RT "Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland
RT development through a p19Arf/p53-independent pathway.";
RL Dev. Dyn. 234:922-933(2005).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27720610; DOI=10.1016/j.devcel.2016.08.007;
RA Luedtke T.H., Rudat C., Wojahn I., Weiss A.C., Kleppa M.J., Kurz J.,
RA Farin H.F., Moon A., Christoffels V.M., Kispert A.;
RT "Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling
RT during Branching Morphogenesis of the Murine Lung.";
RL Dev. Cell 39:239-253(2016).
RN [8]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=33795231; DOI=10.1242/dev.195651;
RA Kaiser M., Wojahn I., Rudat C., Luedtke T.H., Christoffels V.M., Moon A.,
RA Kispert A., Trowe M.O.;
RT "Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner
RT ear morphogenesis in the mouse.";
RL Development 148:0-0(2021).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-705, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-705, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transcriptional repressor involved in developmental processes
CC (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-
CC 3' DNA sequence, or a half-site, which are present in the regulatory
CC region of several genes (By similarity). Probably plays a role in limb
CC pattern formation (By similarity). Required for mammary placode
CC induction, and maintenance of the mammary buds during development
CC (PubMed:16222716). Involved in branching morphogenesis in both
CC developing lungs and adult mammary glands, via negative modulation of
CC target genes; acting redundantly with TBX2 (PubMed:27720610,
CC PubMed:16222716). Required, together with TBX2, to maintain cell
CC proliferation in the embryonic lung mesenchyme; perhaps acting
CC downstream of SHH, BMP and TGFbeta signaling (PubMed:27720610).
CC Involved in modulating early inner ear development, acting
CC independently of, and also redundantly with, TBX2 in different
CC subregions of the developing ear (PubMed:33795231). Acts as a negative
CC regulator of PML function in cellular senescence (By similarity).
CC {ECO:0000250|UniProtKB:O15119, ECO:0000269|PubMed:16222716,
CC ECO:0000269|PubMed:27720610, ECO:0000269|PubMed:33795231}.
CC -!- SUBUNIT: Interacts with PML. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P70324-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P70324-2; Sequence=VSP_013377;
CC -!- TISSUE SPECIFICITY: In adults, highest levels in lung. Also found in
CC brain, heart, kidney, liver and ovary.
CC -!- DEVELOPMENTAL STAGE: At 9.5 dpc, expressed in the otic vesicle, also
CC known as the otocyst (at protein level) (PubMed:33795231). Between
CC 10.5-12.0 dpc, expressed in various regions of the developing ear,
CC including the developing vestibular system and the epithelium of the
CC cochlear duct (at protein level) (PubMed:33795231). Expressed in the
CC blastocyst at 3.5 dpc (PubMed:8853987). At 7.5 dpc, expressed in the
CC extraembryonic endoderm and in the mesoderm of the chorion and amnion
CC (PubMed:8853987). At 9.5 dpc, in the facial region, forelimb,
CC pharyngeal epithelium, mesenchyme of the pharyngeal arches and the
CC lateral body wall and, at 12.5 dpc, in the trigeminal ganglia,
CC developing central nervous system and in the mammary buds
CC (PubMed:8853987). Expressed in a continuous stripe of mesenchyme in the
CC ventro-lateral body wall between the fore and hind limb buds at day
CC 10.5-11.5 dpc (PubMed:16222716). Also expressed in the epithelium of
CC the first and third mammary placodes at 10.5 dpc, and in all five pairs
CC of mammary placodes between 11.5 and 13.5 dpc (PubMed:16222716).
CC {ECO:0000269|PubMed:16222716, ECO:0000269|PubMed:33795231,
CC ECO:0000269|PubMed:8853987}.
CC -!- DISRUPTION PHENOTYPE: Conditional knockdown targeted mainly to lung
CC mesenchyme causes lung hypoplasia at 18.5 dpc (PubMed:27720610).
CC Conditional knockdown targeted mainly to the otic epithelium disrupts
CC inner ear morphogenesis, which is exacerbated by simultaneous
CC conditional knockdown of TBX2 (PubMed:33795231). Simultaneous
CC conditional knockdown of TBX2 and TBX3 targeted mainly to lung
CC mesenchyme causes severe bleeding from 10.5 dpc and embryos die shortly
CC thereafter, perhaps as a result of knockdown in the developing heart
CC (PubMed:27720610). {ECO:0000269|PubMed:27720610,
CC ECO:0000269|PubMed:33795231}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK052453; BAC34999.1; -; mRNA.
DR EMBL; AC140675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U57328; AAC53107.1; -; mRNA.
DR EMBL; U15567; AAC52698.1; -; mRNA.
DR CCDS; CCDS19613.1; -. [P70324-1]
DR CCDS; CCDS19614.1; -. [P70324-2]
DR RefSeq; NP_035665.2; NM_011535.3. [P70324-1]
DR RefSeq; XP_006530339.1; XM_006530276.3. [P70324-1]
DR AlphaFoldDB; P70324; -.
DR SMR; P70324; -.
DR BioGRID; 203988; 5.
DR IntAct; P70324; 2.
DR STRING; 10090.ENSMUSP00000018748; -.
DR iPTMnet; P70324; -.
DR PhosphoSitePlus; P70324; -.
DR MaxQB; P70324; -.
DR PaxDb; P70324; -.
DR PeptideAtlas; P70324; -.
DR PRIDE; P70324; -.
DR ProteomicsDB; 254671; -. [P70324-1]
DR ProteomicsDB; 254672; -. [P70324-2]
DR Antibodypedia; 1789; 474 antibodies from 33 providers.
DR DNASU; 21386; -.
DR Ensembl; ENSMUST00000018748; ENSMUSP00000018748; ENSMUSG00000018604. [P70324-1]
DR Ensembl; ENSMUST00000079719; ENSMUSP00000078657; ENSMUSG00000018604. [P70324-2]
DR Ensembl; ENSMUST00000121021; ENSMUSP00000112519; ENSMUSG00000018604. [P70324-2]
DR GeneID; 21386; -.
DR KEGG; mmu:21386; -.
DR UCSC; uc008zgu.2; mouse. [P70324-1]
DR CTD; 6926; -.
DR MGI; MGI:98495; Tbx3.
DR VEuPathDB; HostDB:ENSMUSG00000018604; -.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000158066; -.
DR HOGENOM; CLU_023038_1_0_1; -.
DR InParanoid; P70324; -.
DR OMA; QGIAMSP; -.
DR PhylomeDB; P70324; -.
DR TreeFam; TF106341; -.
DR BioGRID-ORCS; 21386; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tbx3; mouse.
DR PRO; PR:P70324; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P70324; protein.
DR Bgee; ENSMUSG00000018604; Expressed in undifferentiated genital tubercle and 276 other tissues.
DR ExpressionAtlas; P70324; baseline and differential.
DR Genevisible; P70324; MM.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:BHF-UCL.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; ISO:MGI.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; ISS:UniProtKB.
DR GO; GO:0003167; P:atrioventricular bundle cell differentiation; IMP:MGI.
DR GO; GO:0036302; P:atrioventricular canal development; IGI:BHF-UCL.
DR GO; GO:1905222; P:atrioventricular canal morphogenesis; IGI:BHF-UCL.
DR GO; GO:0001568; P:blood vessel development; IMP:MGI.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
DR GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISO:MGI.
DR GO; GO:1905072; P:cardiac jelly development; ISO:MGI.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IMP:MGI.
DR GO; GO:0060923; P:cardiac muscle cell fate commitment; IMP:MGI.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; IDA:MGI.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISS:UniProtKB.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:MGI.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
DR GO; GO:0003272; P:endocardial cushion formation; ISO:MGI.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0046884; P:follicle-stimulating hormone secretion; ISS:UniProtKB.
DR GO; GO:0035136; P:forelimb morphogenesis; ISO:MGI.
DR GO; GO:0001947; P:heart looping; IMP:MGI.
DR GO; GO:0003007; P:heart morphogenesis; IMP:MGI.
DR GO; GO:0061017; P:hepatoblast differentiation; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IGI:UniProtKB.
DR GO; GO:0035108; P:limb morphogenesis; IMP:MGI.
DR GO; GO:0021761; P:limbic system development; IMP:MGI.
DR GO; GO:0032275; P:luteinizing hormone secretion; ISS:UniProtKB.
DR GO; GO:0030539; P:male genitalia development; ISS:UniProtKB.
DR GO; GO:0030879; P:mammary gland development; IMP:MGI.
DR GO; GO:0060596; P:mammary placode formation; IDA:MGI.
DR GO; GO:0048332; P:mesoderm morphogenesis; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; ISO:MGI.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IMP:MGI.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
DR GO; GO:2000737; P:negative regulation of stem cell differentiation; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0003151; P:outflow tract morphogenesis; IMP:MGI.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0061635; P:regulation of protein complex stability; IMP:MGI.
DR GO; GO:0031647; P:regulation of protein stability; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IGI:MGI.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IMP:UniProtKB.
DR GO; GO:0060931; P:sinoatrial node cell development; IMP:MGI.
DR GO; GO:0001501; P:skeletal system development; ISS:UniProtKB.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IGI:MGI.
DR GO; GO:0010159; P:specification of animal organ position; IDA:MGI.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IMP:MGI.
DR GO; GO:0006351; P:transcription, DNA-templated; IMP:MGI.
DR GO; GO:0072105; P:ureteric peristalsis; IGI:MGI.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IMP:MGI.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..741
FT /note="T-box transcription factor TBX3"
FT /id="PRO_0000184429"
FT DNA_BIND 107..220
FT /note="T-box; first part"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT DNA_BIND 241..305
FT /note="T-box; second part"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 369..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 369
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 456
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 705
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 736
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 738
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 740
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT VAR_SEQ 221..240
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7920656,
FT ECO:0000303|PubMed:8878690"
FT /id="VSP_013377"
FT CONFLICT 154..155
FT /note="DI -> T (in Ref. 3; AAC53107)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="M -> R (in Ref. 3; AAC53107)"
FT /evidence="ECO:0000305"
FT CONFLICT 306..309
FT /note="TGNG -> IGHC (in Ref. 3; AAC53107)"
FT /evidence="ECO:0000305"
FT CONFLICT 569
FT /note="S -> Y (in Ref. 1; BAC34999)"
FT /evidence="ECO:0000305"
FT CONFLICT 717
FT /note="S -> N (in Ref. 1; BAC34999)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 741 AA; 79160 MW; B502FE817EFF124D CRC64;
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL
AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEDVE DDPKVHLEAK ELWDQFHKRG
TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM
PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT
ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA
KGFRDTGNGR REKRKQLTLQ SMRVFEERHK KETSDESSSE QAAFNCFAQA SSPAVSIVGT
SNLKDLCPSE AESDAEAESK EEHGPEACDA AKISTTTAEE PGRDKGSPAT RAQLFPAEPS
RARDTARLDK ASPDSRHSPA TISSSTRVPG ADERRSPGRE GPVATKVDEA RAIPAKDAFA
PLSVQTDATA HLAQGPLPGL GFAPGLAGQQ FFNGHPLFLH PGQFAMGGAF SSMAAGMGPL
LATVSGASTG VSGLESTAMA SAAAAQGLSG ASAATLPFHL QQHVLASQGL AMSPFGSLFP
YPYTYMAAAA AASTAAASSS VHRHPFLNLN SMRPRLRYSP YSIPVPVPDS SSLLATALPS
MASAAGPLDG KAAALAASPA SVAVDSGSEL NSRSSTLSSG SVSLSPKLCS EKEAATSELQ
SIQRLVSGLE AKPDRSCSGS P
