TBX3_RAT
ID TBX3_RAT Reviewed; 743 AA.
AC Q7TST9;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=T-box transcription factor TBX3;
DE Short=T-box protein 3;
GN Name=Tbx3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Fischer 344; TISSUE=Urinary bladder;
RA Ito A., Asamoto M., Hokaiwado N., Inaguma S., Takahashi S., Shirai T.;
RT "Tbx3 is a regulator of apoptosis and cell growth in rat bladder epithelial
RT cells.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434 AND SER-707, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Transcriptional repressor involved in developmental processes
CC (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-
CC 3' DNA sequence, or a half-site, which are present in the regulatory
CC region of several genes (By similarity). Probably plays a role in limb
CC pattern formation (By similarity). Required for mammary placode
CC induction, involved in maintenance of the mammary buds during
CC development and branching morphogenesis in embryonic and adult glands;
CC partially redundant with TBX2 (By similarity). Involved in modulating
CC early inner ear development, acting independently of, and also
CC redundantly with, TBX2 in different subregions of the developing ear
CC (By similarity). Acts as a negative regulator of PML function in
CC cellular senescence (By similarity). {ECO:0000250|UniProtKB:O15119,
CC ECO:0000250|UniProtKB:P70324}.
CC -!- SUBUNIT: Interacts with PML. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR EMBL; AY289619; AAP43504.1; -; mRNA.
DR RefSeq; NP_853669.1; NM_181638.1.
DR RefSeq; XP_006249477.1; XM_006249415.2.
DR RefSeq; XP_006249478.1; XM_006249416.3.
DR RefSeq; XP_006249479.1; XM_006249417.3.
DR AlphaFoldDB; Q7TST9; -.
DR SMR; Q7TST9; -.
DR STRING; 10116.ENSRNOP00000011552; -.
DR iPTMnet; Q7TST9; -.
DR PhosphoSitePlus; Q7TST9; -.
DR jPOST; Q7TST9; -.
DR PaxDb; Q7TST9; -.
DR Ensembl; ENSRNOT00000011552; ENSRNOP00000011552; ENSRNOG00000008706.
DR GeneID; 353305; -.
DR KEGG; rno:353305; -.
DR UCSC; RGD:735203; rat.
DR CTD; 6926; -.
DR RGD; 735203; Tbx3.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000158066; -.
DR InParanoid; Q7TST9; -.
DR OMA; QGIAMSP; -.
DR OrthoDB; 301173at2759; -.
DR PhylomeDB; Q7TST9; -.
DR TreeFam; TF106341; -.
DR PRO; PR:Q7TST9; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000008706; Expressed in esophagus and 17 other tissues.
DR ExpressionAtlas; Q7TST9; baseline and differential.
DR Genevisible; Q7TST9; RN.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009887; P:animal organ morphogenesis; ISO:RGD.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; ISS:UniProtKB.
DR GO; GO:0003167; P:atrioventricular bundle cell differentiation; ISO:RGD.
DR GO; GO:0036302; P:atrioventricular canal development; ISO:RGD.
DR GO; GO:1905222; P:atrioventricular canal morphogenesis; ISO:RGD.
DR GO; GO:0001568; P:blood vessel development; ISO:RGD.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; ISO:RGD.
DR GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISO:RGD.
DR GO; GO:1905072; P:cardiac jelly development; ISO:RGD.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; ISO:RGD.
DR GO; GO:0060923; P:cardiac muscle cell fate commitment; ISO:RGD.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; ISS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISS:UniProtKB.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISS:UniProtKB.
DR GO; GO:0035050; P:embryonic heart tube development; ISO:RGD.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
DR GO; GO:0003272; P:endocardial cushion formation; ISO:RGD.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0046884; P:follicle-stimulating hormone secretion; ISS:UniProtKB.
DR GO; GO:0035136; P:forelimb morphogenesis; ISO:RGD.
DR GO; GO:0001947; P:heart looping; ISO:RGD.
DR GO; GO:0003007; P:heart morphogenesis; ISO:RGD.
DR GO; GO:0061017; P:hepatoblast differentiation; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0035108; P:limb morphogenesis; ISO:RGD.
DR GO; GO:0021761; P:limbic system development; ISO:RGD.
DR GO; GO:0032275; P:luteinizing hormone secretion; ISS:UniProtKB.
DR GO; GO:0030539; P:male genitalia development; ISS:UniProtKB.
DR GO; GO:0030879; P:mammary gland development; ISS:UniProtKB.
DR GO; GO:0060596; P:mammary placode formation; ISO:RGD.
DR GO; GO:0048332; P:mesoderm morphogenesis; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; ISO:RGD.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; ISO:RGD.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
DR GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0003151; P:outflow tract morphogenesis; ISO:RGD.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0061635; P:regulation of protein complex stability; ISO:RGD.
DR GO; GO:0031647; P:regulation of protein stability; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; ISO:RGD.
DR GO; GO:0048752; P:semicircular canal morphogenesis; ISO:RGD.
DR GO; GO:0060931; P:sinoatrial node cell development; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISS:UniProtKB.
DR GO; GO:0051145; P:smooth muscle cell differentiation; ISO:RGD.
DR GO; GO:0010159; P:specification of animal organ position; ISO:RGD.
DR GO; GO:0019827; P:stem cell population maintenance; ISO:RGD.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0072105; P:ureteric peristalsis; ISO:RGD.
DR GO; GO:0060412; P:ventricular septum morphogenesis; ISO:RGD.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..743
FT /note="T-box transcription factor TBX3"
FT /id="PRO_0000184430"
FT DNA_BIND 107..220
FT /note="T-box; first part"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT DNA_BIND 241..305
FT /note="T-box; second part"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 371..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 371
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 434
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 440
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 458
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 707
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 738
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 740
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
FT MOD_RES 742
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15119"
SQ SEQUENCE 743 AA; 79335 MW; A1D3C92A1F0ECAFB CRC64;
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL
AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEDVE DDPKVHLEAK ELWDQFHKRG
TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM
PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT
ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA
KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KETGTSDESS SEQAAFNCFA QASSPAVSTV
GTSNLKDLCP SEAESDAEAE SKEEHGPEAC DTAKISTTTA EEPGRDKGSP ATRAQLFPAE
PSRARDTARL DKASPDSRHS PATISSSTRV PGADEHRSPG REGPVSAKVD EARALPAKDA
FAPLSVQTDA TAHLTQGPLP GLGFAPGLAG QQFFNGHPLF LHPGQFAMGG AFSSMAAGMG
PLLATVSGAS TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL
FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNSMRPRLRY SPYSIPVPVP DSSSLLATAL
PSMASAAGPL DGKSAVLAAS PASVAVDSGS ELNSRSSTLS SGSVSLSPKL CSEKEAATSE
LQSIQRLVSG LEAKPDRSCS GSP
