ID   TBX4_CANLF              Reviewed;         554 AA.
AC   Q861Q9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=T-box transcription factor TBX4;
DE            Short=T-box protein 4;
GN   Name=TBX4;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Andelfinger G., Etter L., Dyment M., Hitte C., Galibert F., Kirkness E.,
RA   Benson D.W.;
RT   "Molecular cloning of canine Tbx2 and Tbx4: exclusion as candidates for
RT   canine tricuspid valve malformation.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator that has an essential role in the
CC       organogenesis of lungs, pelvis, and hindlimbs.
CC       {ECO:0000250|UniProtKB:P57082}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR   EMBL; AY185179; AAO24701.1; -; mRNA.
DR   EMBL; AY185178; AAO24700.1; -; Genomic_DNA.
DR   EMBL; AY185174; AAO24700.1; JOINED; Genomic_DNA.
DR   EMBL; AY185175; AAO24700.1; JOINED; Genomic_DNA.
DR   EMBL; AY185177; AAO24700.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001003006.2; NM_001003006.3.
DR   AlphaFoldDB; Q861Q9; -.
DR   SMR; Q861Q9; -.
DR   STRING; 9612.ENSCAFP00000026178; -.
DR   PaxDb; Q861Q9; -.
DR   GeneID; 403514; -.
DR   KEGG; cfa:403514; -.
DR   CTD; 9496; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   InParanoid; Q861Q9; -.
DR   OrthoDB; 344556at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISS:UniProtKB.
DR   GO; GO:1990401; P:embryonic lung development; ISS:UniProtKB.
DR   GO; GO:0035108; P:limb morphogenesis; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048705; P:skeletal system morphogenesis; ISS:UniProtKB.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..554
FT                   /note="T-box transcription factor TBX4"
FT                   /id="PRO_0000184432"
FT   DNA_BIND        78..258
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         516
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70325"
SQ   SEQUENCE   554 AA;  60994 MW;  F02E2819D11962FE CRC64;
     MLQDKGLSES EEAFRAPGSA LGEASASNAA NAPEPALAAP GLSGAALGSP PGPGADAAAA
     AAAAAAAEQT IENIKVGLHE KELWKKFHEA GTEMIITKAG RRMFPSYKVK VTGMNPKTKY
     ILLIDIVPAD DHRYKFCDNK WMVAGKAEPA MPGRLYVHPD SPATGAHWMR QLVSFQKLKL
     TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNAFGSKNTA FCTHVFPETS FISVTSYQNH
     KITQLKIENN PFAKGFRGSD DSDLRVARLQ SKEYPVISKS IMRQRLVSTQ LSAKPDVSPL
     HGAHQALQHY QYENGAHMQF AAAEPQDLPL NTFPAQRDSS LFYHCLKRRD SARHLDLPCK
     RSYLEAPPAV GEDHYFRSPP PYDQQMLSPS YCSEVTPREA CMYSGSGPEI TGVSGVDDLP
     PPPLSCNMWT SVSPYTSYSV QTMETVPYQS FPTHFTATTM MPRLPAISAP SSQPPGNSHF
     SVYNQLSQSQ VRERGPTTSF QRERGLPSVC ERKPPSPHLN AANEFLYSQS FSLSREASLQ
     YHSGMGTVEN WTDG