ID   TBX6L_CHICK             Reviewed;         361 AA.
AC   P79779;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=T-box-containing protein TBX6L;
DE   Flags: Fragment;
GN   Name=TBX6L;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Embryo;
RX   PubMed=9053317; DOI=10.1242/dev.124.2.411;
RA   Knezevic V., de Santo R., Mackem S.;
RT   "Two novel chick T-box genes related to mouse Brachyury are expressed in
RT   different, non-overlapping mesodermal domains during gastrulation.";
RL   Development 124:411-419(1997).
CC   -!- FUNCTION: May be involved in regulating somitogenesis.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DEVELOPMENTAL STAGE: First detected in stage X-XI blastoderms in the
CC       posterior epiblast. At stage 4, detected in the ectoderm around the
CC       primitive streak and in later stages, expressed exclusively within the
CC       mesoderm of the segmental plate. Expression continues here beyond trunk
CC       and tail bud formation and disappears by stage 26-28.
CC   -!- INDUCTION: By FGF-4, activin and retinoic acid.
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DR   EMBL; U67088; AAC60073.1; -; mRNA.
DR   AlphaFoldDB; P79779; -.
DR   SMR; P79779; -.
DR   STRING; 9031.ENSGALP00000010286; -.
DR   PaxDb; P79779; -.
DR   VEuPathDB; HostDB:geneid_395792; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   InParanoid; P79779; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 2.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..>361
FT                   /note="T-box-containing protein TBX6L"
FT                   /id="PRO_0000184464"
FT   DNA_BIND        36..209
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          203..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..223
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         361
SQ   SEQUENCE   361 AA;  41186 MW;  566756AE2419A128 CRC64;
     MQVLPDIKAP CDALASPSLE PYPQSSITVT LEDMGLWMKF HQIGTEMIIT KSGRRMFPQC
     KIKVSGLIPY AKYLMLVDFV PVDNFRYKWN KDQWEVAGKA EPQLPCRTYV HPDSPAPGSH
     WMKEPVSFQK LKLTNNTLDQ HGHIILHSMH RYKPRFHIVQ ADDLFSVRWS IFQVFSFPET
     VFTSVTAYQN EQITKLKIDN NPFAKGFREH GKNTRREGRA KSQKPSPAKG QKRKLPEEKE
     SGAEERDFEK DENVDVKEES NPIVVSSGYP FWISEQNSSH AFPAASPAPA EQREGPAREQ
     QVPTPSYQTY RFHEAGDSQQ LPSRDVAALN DFRGRCHPLD LATVPEHDSK QLPEGFTNLP
     P