ID   TBX6L_DANRE             Reviewed;         473 AA.
AC   P79742;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=T-box transcription factor TBX6L;
DE            Short=T-box protein 6L;
DE   AltName: Full=T-box transcription factor TBX6;
DE            Short=T-box protein 6;
GN   Name=tbx6l; Synonyms=tbx6;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9119115; DOI=10.1006/dbio.1996.8490;
RA   Hug B., Walter V., Grunwald D.J.;
RT   "tbx6, a Brachyury-related gene expressed by ventral mesendodermal
RT   precursors in the zebrafish embryo.";
RL   Dev. Biol. 183:61-73(1997).
CC   -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC       processes.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed by ventral mesendoderm.
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DR   EMBL; U80951; AAB39319.1; -; mRNA.
DR   AlphaFoldDB; P79742; -.
DR   SMR; P79742; -.
DR   STRING; 7955.ENSDARP00000113982; -.
DR   PaxDb; P79742; -.
DR   ZFIN; ZDB-GENE-980526-171; tbx16l.
DR   eggNOG; KOG3585; Eukaryota.
DR   InParanoid; P79742; -.
DR   Reactome; R-DRE-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:P79742; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR   GO; GO:0048341; P:paraxial mesoderm formation; IGI:ZFIN.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0061053; P:somite development; IGI:ZFIN.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 2.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..473
FT                   /note="T-box transcription factor TBX6L"
FT                   /id="PRO_0000184440"
FT   DNA_BIND        43..217
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          342..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  53477 MW;  10A5066D02AFAD2B CRC64;
     MNHLANNYGY YPQDCRTQYS RMNSAEAELT SLPVHVSLQD RELWDKFSSI GTEMLITKSG
     RRMFPSCKVT VTGLNPKVKY VVIMDMVPFD NHKYKWNKDC WEVNGSSDPH LPNRFFIHPD
     SPAPGQKWMQ YPISFHKLKL TNNTLNSNGL VVLHSMHKYQ PRLHIVQSPD PCTPHNPGAY
     LRFTFPEAAF IAVTAYQNQE ITKLKIDNNP FAKGFRDNGL NRKRFRDKGT QEMQDTDRQV
     KLDLTANECA AGMSQMVEDV DVSVSSSVDC RDTQNSSSVS LNPFISAFTN PSSAGGAAAH
     QTHTLLSLSN RHFSSPRESN LNSVCAALPV SQLSTGHTSF SRLNPQETHH NSRPKIQLQP
     PHPSLQCHDL DVRLPLPPKL SRVQLSESAL RNLEMSPLSD CANPRPLTNI LNRSCFRAST
     PSGKLLPNPP QPEQFLRGSE REIYPAVQEY TDQQFTLNSQ TEHRPHMRPL TEY