ID   TBX6_BOVIN              Reviewed;         457 AA.
AC   E1BEA8;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=T-box transcription factor TBX6;
DE            Short=T-box protein 6;
GN   Name=TBX6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
CC   -!- FUNCTION: T-box transcription factor that plays an essential role in
CC       the determination of the fate of axial stem cells: neural vs
CC       mesodermal. Acts in part by down-regulating, a specific enhancer (N1)
CC       of SOX2, to inhibit neural development. Seems to also play an essential
CC       role in left/right axis determination and acts through effects on Notch
CC       signaling around the node as well as through an effect on the
CC       morphology and motility of the nodal cilia (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a dimeric complex with DNA (in vitro).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR   EMBL; DAAA02057895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E1BEA8; -.
DR   SMR; E1BEA8; -.
DR   STRING; 9913.ENSBTAP00000011919; -.
DR   PaxDb; E1BEA8; -.
DR   PRIDE; E1BEA8; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   HOGENOM; CLU_584704_0_0_1; -.
DR   InParanoid; E1BEA8; -.
DR   OrthoDB; 828211at2759; -.
DR   TreeFam; TF106341; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..457
FT                   /note="T-box transcription factor TBX6"
FT                   /id="PRO_0000417042"
FT   DNA_BIND        101..274
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..78
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..293
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  49686 MW;  9DB5E61ED98D9A5C CRC64;
     MYHPRELYPS LGTGYRLGPP QPGADSSFPP ALAEGYRYPD LDTPKLDCFL SGIEAAPRTL
     AAPPPLPPLP PALGTEPSPP SAPEGLHSLP GVSLSLENRE LWKEFNSVGT EMIITKAGRR
     MFPACRVSVT GLDPEARYLF LLDVVPVDGA RYRWQGRRWE PSGKAEPRLP DRVYIHPDSP
     ATGAHWMRQP VSFHRVKLTN STLDPHGHLI LHSMHKYQPR IHLVRAAQLC SQHWGGVASF
     RFPETTFISV TAYQNPRITQ LKIAANPFAK GFRENGRNCK RERDARVKRK LRGPEPAATA
     GYGSGDAPGG PCDSTLGGDV RESDPEQAPV PGLPLPQLLP AVAPVLRPTC CTLPLSTGPP
     VTFQPGIPAS RRLQTLPSAL LSRLPGAAAR ASRLRIPSSS TLSILCLALP PRGPLPTALP
     WAWGLPRCGL QTNVLSLCSL PPGLLPPHFH YPFPHTK