TBX6_DANRE
ID TBX6_DANRE Reviewed; 874 AA.
AC Q8JIS6; Q8JIR5;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=T-box transcription factor TBX6;
DE Short=T-box protein 6;
DE AltName: Full=T-box transcription factor TBX24;
DE Short=T-box protein 24;
GN Name=tbx6; Synonyms=tbx24;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RC STRAIN=AB;
RX PubMed=12021786; DOI=10.1038/ng899;
RA Nikaido M., Kawakami A., Sawada A., Furutani-Seiki M., Takeda H., Araki K.;
RT "Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-
RT segmentation mutant fused somites.";
RL Nat. Genet. 31:195-199(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: T-box transcription factor involved in the development of
CC paraxial mesoderm. {ECO:0000269|PubMed:12021786}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DEVELOPMENTAL STAGE: Expressed in intermediate to anterior presomitic
CC mesoderm. {ECO:0000269|PubMed:12021786}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in a
CC complete inhibition of the segmentation of the presomitic mesoderm.
CC {ECO:0000269|PubMed:12021786}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB072411; BAB97298.1; -; Genomic_DNA.
DR EMBL; AB036516; BAB97199.1; -; mRNA.
DR EMBL; AL929495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163297; AAI63297.1; -; mRNA.
DR RefSeq; NP_705952.2; NM_153666.2.
DR AlphaFoldDB; Q8JIS6; -.
DR SMR; Q8JIS6; -.
DR STRING; 7955.ENSDARP00000015108; -.
DR PaxDb; Q8JIS6; -.
DR Ensembl; ENSDART00000013465; ENSDARP00000015108; ENSDARG00000011785.
DR GeneID; 192294; -.
DR KEGG; dre:192294; -.
DR CTD; 6911; -.
DR ZFIN; ZDB-GENE-020416-5; tbx6.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000160732; -.
DR HOGENOM; CLU_016049_0_0_1; -.
DR InParanoid; Q8JIS6; -.
DR OMA; QQTSFTF; -.
DR OrthoDB; 1185429at2759; -.
DR TreeFam; TF106341; -.
DR Reactome; R-DRE-8953750; Transcriptional Regulation by E2F6.
DR PRO; PR:Q8JIS6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 12.
DR Bgee; ENSDARG00000011785; Expressed in tail bud paraxial mesoderm and 27 other tissues.
DR GO; GO:0000785; C:chromatin; IDA:ZFIN.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:ZFIN.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:ZFIN.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0048641; P:regulation of skeletal muscle tissue development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021523; P:somatic motor neuron differentiation; IMP:ZFIN.
DR GO; GO:0061053; P:somite development; IMP:ZFIN.
DR GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..874
FT /note="T-box transcription factor TBX6"
FT /id="PRO_0000417044"
FT DNA_BIND 71..243
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 364..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..540
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..695
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 50..52
FT /note="ANT -> GNI (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="T -> A (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 294
FT /note="T -> S (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="T -> N (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="S -> T (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="P -> S (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 650
FT /note="S -> N (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 716
FT /note="P -> S (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 757
FT /note="T -> S (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
FT CONFLICT 798
FT /note="A -> T (in Ref. 1; BAB97199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 874 AA; 94964 MW; CDF2095559917A7C CRC64;
MLGVEMYPGL ALGPQRLSDC YYRDRDVPLY PSTCEMAARA LPPALLKPHA NTDSPATPQD
SVRMELENAG LWKQFSTVGT EMIVTKKGRR MFPQLRVKLS GLNPSLRYIL LLDIVPVDSS
RYRFQDNSWQ VVGGAEARLP DRVFIHPDSP ATGEHWQNRT ISFHRAKLTN NTLDAQGYII
LHSLHRYQPR VHVIEARDVL MWGRTQHSFT FPETQFITVT AYQNNKITEL KINSNPFAKG
FRENGMNCKK QREARLKRKI TSSQEECLDI ESCDPCDSTE LLPQSVDLPS SALTIMNTAL
PITDSGFHTE VSSHPDQTDS DQTLVLEQAF LTSEMPSSME SQQQTTSETN VNNALMDETG
QMMDLSGYTS SFPTPQLSSH TSVPQSSSMY SVVSSTQSSD LELPQASSIS SPHSMPAYSS
IPSAEYPGVN SSTAMPASTT SLSDSYPSIS HSTSSHLLQS SSYHSLLPTD QSQDNLSPHT
PTNPPFQSIP ACQGTRLTID SGQNQVDDGG LSSANATTPA VPNPTQTAFP FPPVQPNNDP
DPTSPSCQSL PQSALPYQQV SQCNQIPTPS DPNTTPTAFP FPPSEQSTPN SIMVSSNPNT
TAFPFPPVQQ QLNLSTSGPS SFPVSQSSGL NAIPNPVHPT TGSFSFPSTS AIHQGPMQSV
PNTLHPSTAY TFPSSLPKHT GPLPNPAPTS YPFPTPIPPG PHPLQSLTLP SSCSIPNTSQ
IQSTFPQSYH NPSFSHIPPQ MANHSQITSQ SFPPLQTSSA PQLLSQSSTH PQCPPPSNAY
PAVAPTEIGT FPQLNSAAPY LPDVVLHPSI LPSLDPSLSS SAPPSLYNPF PSYSLRLCQD
PRSSLHLPLR HIYRQPQHAH GQGSYFDLGG RTVF
