TBX6_XENTR
ID TBX6_XENTR Reviewed; 517 AA.
AC Q66JL1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=T-box transcription factor TBX6;
DE Short=T-box protein 6;
GN Name=tbx6 {ECO:0000312|EMBL:CAJ83550.1}; ORFNames=TGas124n10.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ83550.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83550.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ83550.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83550.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional activator. Plays a role in ventral mesoderm
CC specification and acts together with nog during muscle differentiation.
CC Mediates posterior pattern formation of the embryo, including
CC specification of posterior mesoderm, via activation of the Wnt and Fgf
CC signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q8AV66}.
CC -!- SUBUNIT: Interacts with ripply2.2/bowline. Associates with tle4 in the
CC presence of ripply2.2/bowline (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
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DR EMBL; CR942588; CAJ83550.1; -; mRNA.
DR EMBL; BC080873; AAH80873.1; -; mRNA.
DR RefSeq; NP_001007995.1; NM_001007994.1.
DR AlphaFoldDB; Q66JL1; -.
DR SMR; Q66JL1; -.
DR DNASU; 493357; -.
DR GeneID; 493357; -.
DR KEGG; xtr:493357; -.
DR CTD; 6911; -.
DR Xenbase; XB-GENE-6257419; tbx6.
DR InParanoid; Q66JL1; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0017053; C:transcription repressor complex; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0003205; P:cardiac chamber development; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
DR GO; GO:0001947; P:heart looping; IBA:GO_Central.
DR GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR GO; GO:0007517; P:muscle organ development; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 2.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Wnt signaling pathway.
FT CHAIN 1..517
FT /note="T-box transcription factor TBX6"
FT /id="PRO_0000302092"
FT DNA_BIND 105..278
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 276..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..358
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57579 MW; 68C9ADA225305978 CRC64;
MYHSELFQQY GTSYGMRPPH ALAPTYPTAG GHHEAYRYPE LDVPGQRFDG LFPALDPSQR
ILGAPPLTPL SLPPGPALGF GQLQPPCETP QLPGNVKMNL ENKELWKQFH SIGTEMIITK
SGRRMFPQCK VSVTGLEPDG KYLLLADIVP IDNSRYKWQE DRWEPSGRAE PRLPERVYIH
PDSPAPGSHW MKQPISFHKI KLTNNTLDQM GHIILHSMHK YQPRFHIVRA QDVFSRRWGG
CSSFTFPETL FLTVTAYQNE KITQLKIQTN PFAKGFREDG MKSKRDRSTR VKRKVIEPEE
EEEEFQPEGE CKRPLYTGPC DSTLSEELDI GRGLGIPLPS PDCSFHPITP PSRTPPSTQT
PNPSLTANQE QGAALEMSSQ TPETFLQAAG QSYPEQPPVR GGSLYPCPTD GHGAQNQRHP
LSVQRLPQAF QGLQESLGNS PGEYKIYGGD VGCGGDFAPP SCAVAPSVRP SEERLPRGYS
MNSELRFPHF LPNGGSKIGL QFSGAQLQRL YNGGGWM
