ID   TBX7_CAEEL              Reviewed;         335 AA.
AC   Q95PX3; A0A0K3ARF9; A0A0K3AUZ0; Q23467;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-APR-2018, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Putative T-box protein 7;
GN   Name=tbx-7 {ECO:0000312|WormBase:ZK328.8b};
GN   ORFNames=ZK328.8 {ECO:0000312|WormBase:ZK328.8b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b {ECO:0000312|WormBase:ZK328.8b};
CC         IsoId=Q95PX3-1; Sequence=Displayed;
CC       Name=a {ECO:0000312|WormBase:ZK328.8a};
CC         IsoId=Q95PX3-2; Sequence=VSP_059559;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284603; CTQ86630.1; -; Genomic_DNA.
DR   EMBL; BX284603; CTQ86631.1; -; Genomic_DNA.
DR   PIR; C56530; C56530.
DR   PIR; T29011; T29011.
DR   RefSeq; NP_001299930.1; NM_001313001.1.
DR   RefSeq; NP_001299931.1; NM_001313002.1.
DR   AlphaFoldDB; Q95PX3; -.
DR   SMR; Q95PX3; -.
DR   STRING; 6239.ZK328.8.1; -.
DR   PaxDb; Q95PX3; -.
DR   PRIDE; Q95PX3; -.
DR   EnsemblMetazoa; ZK328.8a.1; ZK328.8a.1; WBGene00006544. [Q95PX3-2]
DR   EnsemblMetazoa; ZK328.8b.1; ZK328.8b.1; WBGene00006544. [Q95PX3-1]
DR   UCSC; ZK328.8; c. elegans. [Q95PX3-1]
DR   WormBase; ZK328.8a; CE50285; WBGene00006544; tbx-7. [Q95PX3-2]
DR   WormBase; ZK328.8b; CE50302; WBGene00006544; tbx-7. [Q95PX3-1]
DR   eggNOG; KOG3585; Eukaryota.
DR   GeneTree; ENSGT00940000163374; -.
DR   HOGENOM; CLU_861194_0_0_1; -.
DR   InParanoid; Q95PX3; -.
DR   OMA; KSKYIVM; -.
DR   OrthoDB; 1185429at2759; -.
DR   PhylomeDB; Q95PX3; -.
DR   Reactome; R-CEL-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR   PRO; PR:Q95PX3; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006544; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:WormBase.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:WormBase.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:WormBase.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..335
FT                   /note="Putative T-box protein 7"
FT                   /id="PRO_0000184470"
FT   DNA_BIND        73..246
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   VAR_SEQ         1..36
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059559"
SQ   SEQUENCE   335 AA;  38189 MW;  D8D758F36A8256F5 CRC64;
     MYFQILVLMS EGYGRSLFSE KHFPHDRQLL PPFTTTMSLG SFFSFPASSA FFDRKKDDGV
     IDNPNVELVN RNLWSTFLEC GTEMIITKKG RRMFPLVKLK LSGLDKNSNY TIIMEMISVD
     KLRYKFWNGN WIVAGVGEHH PLPTCFVHPQ SPRSGEWWMT DGVDFKMAKL SNNPFNNDGH
     IVLNSMHRYN PRFHIVRADS SGQPILASLK TFSFKETEFI AVTAYQNDVV TKCKIDNNPF
     AKGFRNIDTV RKRKMNQIIS TPPASEDEEP EVKRTKSEIE AVMFSDPKVP QMSLQLISQW
     QEALLSTIVQ IPITNQKSSS ERKSGFGVVD LLGSS