ID   TBXT1_BRAFL             Reviewed;         448 AA.
AC   Q17134;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=T-box transcription factor T homolog 1 {ECO:0000305};
DE   AltName: Full=AmBra-1;
DE   AltName: Full=Brachyury protein homolog 1 {ECO:0000305};
GN   Name=TBXT {ECO:0000250|UniProtKB:O15178}; Synonyms=BRA-1;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Larva;
RX   PubMed=8575328; DOI=10.1242/dev.121.12.4283;
RA   Holland P.W.H., Koschorz B., Holland L.Z., Herrmann B.G.;
RT   "Conservation of Brachyury (T) genes in amphioxus and vertebrates:
RT   developmental and evolutionary implications.";
RL   Development 121:4283-4291(1995).
CC   -!- FUNCTION: Involved in the transcriptional regulation of genes required
CC       for mesoderm formation and differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- DEVELOPMENTAL STAGE: First detected in the 10 hours gastrula around the
CC       blastopore. In later stages of gastrulation and early neuralization,
CC       expressed in posterior mesoderm and the notochord where expression
CC       continues at least until swimming larval stage.
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DR   EMBL; X91903; CAA62999.1; -; mRNA.
DR   AlphaFoldDB; Q17134; -.
DR   SMR; Q17134; -.
DR   STRING; 7739.XP_002590391.1; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..448
FT                   /note="T-box transcription factor T homolog 1"
FT                   /id="PRO_0000184419"
FT   DNA_BIND        54..224
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          290..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  49253 MW;  43326D32FD4BC156 CRC64;
     MSSAETMKQP TAASPDQFSV SHLLSAVESE ISAGSEKGDP TERDLKITLE EKPLWDKFNA
     LTNEMIVTKN GRRMFPVLKV NVSGLDPNAM YSFLLDFTAA DNHRWKYVNG EWVPGGKPEP
     SVPSCVYIHP DSPNFGAHWM KSPVSFSKVK LTNKLNGGGQ IMLNSLHKYE PRLHIIKVGG
     PDNQRMVSTH TFPETQFIAV TAYQNEEITA LKIKYNPFAK AFLDAKERSD GKDGMEDLQD
     QPQYSQLGGW FLPGTGPICP PPNPHQFAPS LGLPSHGCDR YSTLRNHRSA PYPHPYQRSS
     PPTNYGHDTA ASLPMMPTHD NWSGLPVSTH NMLSMSAMPH TTTSTHAQYP NLWSVSNNNL
     TPTTHAQTHM SGTMGTGLPH QFLRTTAPAP YHSIPTCTVP TTASSSPVYH DSHEVSSTDS
     GYGHSTTPPA PQTRITSNNW SPMTPPSL