ID   TBXT2_BRAFL             Reviewed;         440 AA.
AC   P80492;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=T-box transcription factor T homolog 2 {ECO:0000305};
DE   AltName: Full=AmBra-2;
DE   AltName: Full=Brachyury protein homolog 2 {ECO:0000305};
GN   Name=TBXT {ECO:0000250|UniProtKB:O15178}; Synonyms=BRA-2;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8575328; DOI=10.1242/dev.121.12.4283;
RA   Holland P.W.H., Koschorz B., Holland L.Z., Herrmann B.G.;
RT   "Conservation of Brachyury (T) genes in amphioxus and vertebrates:
RT   developmental and evolutionary implications.";
RL   Development 121:4283-4291(1995).
CC   -!- FUNCTION: Involved in the transcriptional regulation of genes required
CC       for mesoderm formation and differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- TISSUE SPECIFICITY: Mesoderm and notochord.
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DR   RefSeq; XP_002590390.1; XM_002590344.1.
DR   AlphaFoldDB; P80492; -.
DR   SMR; P80492; -.
DR   STRING; 7739.XP_002590390.1; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   OMA; RNDHKDM; -.
DR   OrthoDB; 1201455at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..440
FT                   /note="T-box transcription factor T homolog 2"
FT                   /id="PRO_0000184420"
FT   DNA_BIND        44..215
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          282..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  48469 MW;  F12EBC417243D3D6 CRC64;
     MKQTPDQFSV SHLLSAVESE ISAGSEKGDP TERDLKVTLG EKPLWEKFKS LTNEMIVTKS
     GRRMFPVLKV NVSGLDPNAM YSFLLDFTAA DNHRWKYVNG EWVPGGKPEP SVPSCVYIHP
     DSPNFGAHWM KSPVSFSKVK LTNKLNGGGQ QIMLNSLHKY EPRIHIVKVG GPDNQRTLST
     HTFAETQFIA VTAYQNEELT ALKIKHNPFA KAFLDAKERN DTKSGHDDLT DQQPQFSQLG
     GWFLPGTGPI CPPPNPHQFA PSLGLPSHGC DRYSTLRNHR SAPYPHPYQR SSPPTNYGHD
     TAASLPMMPT HDNWSGLPVS THNMLSMSAM PHTTTSTHAQ YPNLWSVSNN NLTPTTHAQT
     HMSGTMGTGL PHQFLRTTAP APYHSIPTCT VPTTASSSPV YHDSHEVSST DSGYGHSTTP
     PAPQTRITSN NWSPMTMPSM