ID   TBXT_CHICK              Reviewed;         433 AA.
AC   P79777; Q90654;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=T-box transcription factor T {ECO:0000305};
DE   AltName: Full=Brachyury protein {ECO:0000305};
DE   AltName: Full=Protein T;
GN   Name=TBXT {ECO:0000250|UniProtKB:O15178}; Synonyms=T;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7729577; DOI=10.1006/dbio.1995.1090;
RA   Kispert A., Ortner H., Cooke J., Herrmann B.G.;
RT   "The chick Brachyury gene: developmental expression pattern and response to
RT   axial induction by localized activin.";
RL   Dev. Biol. 168:406-415(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Embryo;
RX   PubMed=9053317; DOI=10.1242/dev.124.2.411;
RA   Knezevic V., de Santo R., Mackem S.;
RT   "Two novel chick T-box genes related to mouse Brachyury are expressed in
RT   different, non-overlapping mesodermal domains during gastrulation.";
RL   Development 124:411-419(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RA   Huang J.X., Wendler C.C., Morrice D.R., Burt D.W., Runyan R.B.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the transcriptional regulation of genes required
CC       for mesoderm formation and differentiation. Binds to a palindromic site
CC       (called T site) and activates gene transcription when bound to such a
CC       site. {ECO:0000250, ECO:0000250|UniProtKB:P20293}.
CC   -!- SUBUNIT: Monomer. Binds DNA as a monomer. {ECO:0000250,
CC       ECO:0000250|UniProtKB:P20293}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15178}.
CC   -!- DEVELOPMENTAL STAGE: First expressed in the posterior epiblast of stage
CC       XIII blastoderm, then in the elongating primitive streak, early
CC       migrating mesoderm, Hensen node and in the notochord. In later stages,
CC       found in tail bud and entire notochord up to stage 26-28.
CC   -!- INDUCTION: By FGF-4 and activin.
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DR   EMBL; U67086; AAC60283.1; -; mRNA.
DR   EMBL; U25176; AAA67365.1; -; mRNA.
DR   AlphaFoldDB; P79777; -.
DR   SMR; P79777; -.
DR   STRING; 9031.ENSGALP00000018703; -.
DR   PaxDb; P79777; -.
DR   VEuPathDB; HostDB:geneid_395782; -.
DR   eggNOG; KOG3585; Eukaryota.
DR   InParanoid; P79777; -.
DR   OrthoDB; 1201455at2759; -.
DR   PhylomeDB; P79777; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051087; F:chaperone binding; IPI:AgBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR   GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR   GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001756; P:somitogenesis; IBA:GO_Central.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..433
FT                   /note="T-box transcription factor T"
FT                   /id="PRO_0000184416"
FT   DNA_BIND        49..217
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   CONFLICT        250
FT                   /note="A -> T (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  47289 MW;  8C0C27577E82872F CRC64;
     MGSPEDAGKA PAYRVDHLLS AVESELQAGS EKGDPTEREL RVALEDGELW LRFKELTNEM
     IVTKNGRRMF PVLKVSVSGL DPNAMYSFLL DFVAADGHRW KYVNGEWVPG GKPEPQAPSC
     VYIHPDSPNF GAHWMKAPVS FSKVKLTNKL NGGGQIMLNS LHKYEPRIHI VRVGGPQRMI
     TSHSFPETQF TAVTAYQNEE ITALKIKYNP FAKAFLDAKE RNDHKDMMEE AGDNQQSGYS
     QLGSWLIPGA GALCPPANPH SQFGAPLSLS PAHSCERYSP LRNHRSAPYP NPYTHRNNSP
     TAYTDNSSAC LPMLQSHDNW SSLGVPTHTT MLPMSHSTGT ATSSSQYPNL WSVSNSTITP
     APQSSGMSNG LSSQFLRGSP VHYTALPHPV TATTSTSPLY DGGAPADLPD SQYDASAHTR
     LASMWTPITP PSM