ID   TBXT_HALRO              Reviewed;         471 AA.
AC   P56158;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=T-box transcription factor T {ECO:0000305};
DE   AltName: Full=AS-T;
DE   AltName: Full=Brachyury protein homolog {ECO:0000305};
DE   AltName: Full=Protein T;
GN   Name=TBXT {ECO:0000250|UniProtKB:O15178}; Synonyms=T;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RA   Yasuo H., Satoh N.;
RT   "An ascidian homolog of the mouse Brachyury (T) gene is expressed
RT   exclusively in notochord cells at the fate restricted stage.";
RL   Dev. Growth Differ. 36:9-18(1995).
CC   -!- FUNCTION: Involved in the transcriptional regulation of genes required
CC       for mesoderm differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- TISSUE SPECIFICITY: Developing notochord.
CC   -!- DEVELOPMENTAL STAGE: First detected in 64-cell embryos. Reaches maximal
CC       levels at the gastrula stage, decreases in neurula stage and barely
CC       detectable in larvae.
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DR   EMBL; D16441; BAA03910.1; -; mRNA.
DR   AlphaFoldDB; P56158; -.
DR   SMR; P56158; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..471
FT                   /note="T-box transcription factor T"
FT                   /id="PRO_0000184421"
FT   DNA_BIND        24..196
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
SQ   SEQUENCE   471 AA;  52417 MW;  096B8BDC42F205C4 CRC64;
     MSITNNMESP SDSEVRLTLN DRALWTKFCS LTNEMIVTKS GRRMFPVLKL TASGLEPNSM
     YSFLLDFAPA DSNRWKYVNG EWVPGGKPEP HAASCVYVHP DSPNFGSHWM KQPVSFNKVK
     LTNKGNGGGQ QIMLNSLHKY EPRIHVVKVG GEAASERTIA TFSFPESQFI AVTAYQNEEV
     TSLKIKHNPF AKAFLDAKER PDQTDFHSLA GIPVSSPQVP SWYGRNGSTS SARHFTHCNS
     YGGESELTSV QDTAIPSYTS RNCMRNSYRG NARATPYTIP HKELTCQATS FPEPVPNDGF
     YPMFPNSELL PRTTLNNYSP AMGAYTNSSI VTSSDIQSGN NNNFFYSNNN NINTTDEVPT
     TYMTNDFNSF YNQSSNSGMP GTTYLPYQSS PVNQFYSYQP PYSTEIADIS PTQQDIINAQ
     NPYQTAWTPP LSYDGCSTMY NSITPYSSSG ESTTSEMTLL ATARYLQNLR L