ID   TBXT_HEMPU              Reviewed;         434 AA.
AC   Q25113;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=T-box transcription factor T homolog {ECO:0000305};
DE   AltName: Full=Brachyury protein homolog;
DE   AltName: Full=HpTa;
DE   AltName: Full=Protein T;
GN   Name=TBXT {ECO:0000250|UniProtKB:O15178}; Synonyms=TA;
OS   Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Hemicentrotus.
OX   NCBI_TaxID=7650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7555703; DOI=10.1242/dev.121.9.2747;
RA   Harada Y., Yasuo H., Satoh N.;
RT   "A sea urchin homologue of the chordate Brachyury (T) gene is expressed in
RT   the secondary mesenchyme founder cells.";
RL   Development 121:2747-2754(1995).
CC   -!- FUNCTION: Involved in the transcriptional regulation of genes required
CC       for mesoderm differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC   -!- TISSUE SPECIFICITY: In the developing embryo, expressed in the
CC       mesenchyme founder cells, vegetal plate of the mesenchyme blastula,
CC       extending tip of the invaginating archenteron and, later, in the
CC       secondary mesenchyme cells.
CC   -!- DEVELOPMENTAL STAGE: First detected in the swimming blastula, maximally
CC       expressed in the gastrula. Levels decrease in the prism larval stage
CC       and are barely detectable by the pluteus larval stage.
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DR   EMBL; D50332; BAA08869.1; -; mRNA.
DR   AlphaFoldDB; Q25113; -.
DR   SMR; Q25113; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..434
FT                   /note="T-box transcription factor T homolog"
FT                   /id="PRO_0000184422"
FT   DNA_BIND        50..220
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          355..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  46714 MW;  AAA502DA838D0A06 CRC64;
     MPAMSADALR APSYNVSHLL NAVQSEMNRG SEKGDPSEEG LKVRLDDVEL WKKFHKLTNE
     MIVTKSGRRM FPVLSASIAG LDPNSMYSVL LDFSAADDHR WKYVNGEWIP GGKPDGSPPT
     TAYIHPDSPN FGAHWMKQAV NFSKVKLSNK LNGSGQVMLN SLHKYEPRIH IIRVGGREKQ
     RLVGSYSFTE TRFIAVTAYQ NEDITQLKIK YNPFAKAFLD IKDKNDGHDL FDDVHDFQGS
     KYPQFGGWFL PGSGAFGPTP HQFNPSIGLP SHAGCDRYGG LRSHRTSPYP PPPYHQKYSA
     AGAGYGAEAS AGLSSSISLL AADSWSSLAN STSAASSMPA CSQYGSMWPS TAATSGFSHV
     SSPQSPLPTG LFRNPHPTSS HQHNLASTAH GMAPVASGLP SAAVTTANSS EAHALSQSVM
     APGECRASDN AGYL