ID   TBXT_PATPE              Reviewed;         453 AA.
AC   Q9U903;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=T-box transcription factor T homolog {ECO:0000305};
DE   AltName: Full=ApBra {ECO:0000312|EMBL:BAA84938.1};
DE   AltName: Full=Brachyury protein homolog {ECO:0000303|PubMed:10354483};
GN   Name=TBXT {ECO:0000250|UniProtKB:O15178};
GN   Synonyms=Bra {ECO:0000312|EMBL:BAA84938.1};
OS   Patiria pectinifera (Starfish) (Asterina pectinifera).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Valvatacea; Valvatida; Asterinidae; Patiria.
OX   NCBI_TaxID=7594;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAA84938.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:10354483};
RX   PubMed=10354483; DOI=10.1016/s0925-4773(99)00008-8;
RA   Shoguchi E., Satoh N., Maruyama Y.K.;
RT   "Pattern of Brachyury gene expression in starfish embryos resembles that of
RT   hemichordate embryos but not of sea urchin embryos.";
RL   Mech. Dev. 82:185-189(1999).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=10831044; DOI=10.1046/j.1440-169x.2000.00481.x;
RA   Shoguchi E., Satoh N., Maruyama Y.K.;
RT   "A starfish homolog of mouse T-brain-1 is expressed in the archenteron of
RT   Asterina pectinifera embryos: possible involvement of two T-box genes in
RT   starfish gastrulation.";
RL   Dev. Growth Differ. 42:61-68(2000).
CC   -!- FUNCTION: May be involved in the transcriptional regulation of genes
CC       required for gastrulation. {ECO:0000269|PubMed:10831044,
CC       ECO:0000305|PubMed:10354483}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201,
CC       ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: First detected 17 hours after insemination at the
CC       vegetal pole in late blastula. In 20 hour gastrula, expressed around
CC       the base of the archenteron and the lateral embryonic wall but not in
CC       the invaginated cells of the archenteron. In 34 hour gastrula
CC       expression persists around the base of the archenteron or at the
CC       blastopore but is not detected in either mesenchyme cells or the
CC       archenteron. In mouth forming embryos and in early bipinnaria larvae
CC       expressed in cells around the blastopore and anus. Not detected in
CC       cells of the mesenchyme and coelomic vesicles derived from the
CC       archenteron. {ECO:0000269|PubMed:10354483}.
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DR   EMBL; AB018527; BAA84938.1; -; mRNA.
DR   AlphaFoldDB; Q9U903; -.
DR   SMR; Q9U903; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00182; TBOX; 1.
DR   Gene3D; 2.60.40.820; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; PTHR11267; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..453
FT                   /note="T-box transcription factor T homolog"
FT                   /id="PRO_0000420238"
FT   DNA_BIND        47..217
FT                   /note="T-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT   REGION          283..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  49376 MW;  D9B5CFBADCC9FA34 CRC64;
     MSADTMRAPT YNVAHLLSAV QSEMTRGSEK GDPSEKGLKV TLEDRDLWRR FSKLTNEMIV
     TKTGRRMFPV LSASVTGLNP NAMYSILLDF TPADEHRWKY VNGEWVPGGK PDSPPPSTAY
     IHPDSPNFGA HWMKQCVSFS KVKLSNKLNG TGQIMLNSLH KYEPRIHVIR VGGPEKQRLI
     RSFSFPETQF IAVTAYQNED ITQLKIKYNP FAKAFLDIKE KGEHEFEDCH DHQQPRYPQL
     GSWFLPSAGT LCPPSPHHQF PPSLGMPSPV SHSCAVERYG SLRSHRSTPY PPPPYEQKYS
     PTSAYATDST ASSLSLLPAH EAWSPLGSST HHTSNITTSP SHQYGGVWPP VTSSAVQPAS
     SCGVGSPVHT SLLRAAYSNY SQPSTSSITG VPRPPAGSMS SSCAGYQNYN SPSEIHGGLN
     STDAIGSYPT VGNQLCPGKV GAWSPLTPPS PGV