TCAA_STAAT
ID TCAA_STAAT Reviewed; 460 AA.
AC A8Z547;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Membrane-associated protein TcaA;
GN Name=tcaA; OrderedLocusNames=USA300HOU_2338;
OS Staphylococcus aureus (strain USA300 / TCH1516).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=451516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300 / TCH1516;
RX PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT "Subtle genetic changes enhance virulence of methicillin resistant and
RT sensitive Staphylococcus aureus.";
RL BMC Microbiol. 7:99-99(2007).
CC -!- FUNCTION: Plays a major role in decreasing resistance to glycopeptide
CC antibiotics. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TcaA family. {ECO:0000305}.
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DR EMBL; CP000730; ABX30330.1; -; Genomic_DNA.
DR RefSeq; WP_000833797.1; NC_010079.1.
DR AlphaFoldDB; A8Z547; -.
DR KEGG; sax:USA300HOU_2338; -.
DR HOGENOM; CLU_047245_0_0_9; -.
DR OMA; RTYNWTY; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR023599; Mem_prot_TcaA.
DR PIRSF; PIRSF032522; TcaA; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell membrane; Membrane; Metal-binding;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..460
FT /note="Membrane-associated protein TcaA"
FT /id="PRO_0000333171"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..460
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT ZN_FING 4..21
FT /note="C4-type"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 52114 MW; 99B31F11D2987FC6 CRC64;
MKSCPKCGQQ AQDDVQICTQ CGHKFDSRQA LYRKSTDEDI QTNNIKMRKM VPWAIGFFIL
ILIIILFFLL RNFNSPEAQT KILVNAIENN DKQKVATLLS TKDNKVDSEE AKVYINYIKD
EVGLKQFVSD LKNTVHKLNK SKTSVASYIQ TRSGQNILRV SKNGTRYIFF DNMSFTAPTK
QPIVKPKEKT KYEFKSGGKK KMVIAEANKV TPIGNFIPGT YRIPAMKSTE NGDFAGHLKF
DFRQSNSETV DVTEDFEEAN ISVTLKGDTK LNDSSKKVTI NDHEMAFSSS KTYGPYPQNK
DITISASGKA KDKTFTTQTK TIKASDLKYN TEITLNFDSE DIEDYVEKKE KEENSLKNKL
IEFFAGYSLA NNAAFNQSDF DFVSSYIKKG SSFYDDVKKR VSKGSLMMIS SPQIIDAEKH
GDKITATVRL INENGKQVDK EYELEQGSQD RLQLIKTSEK