ID   TCAA_STAEQ              Reviewed;         462 AA.
AC   Q5HLN7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Membrane-associated protein TcaA;
GN   Name=tcaA; OrderedLocusNames=SERP1948;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Plays a major role in decreasing resistance to glycopeptide
CC       antibiotics. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TcaA family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW52830.1; -; Genomic_DNA.
DR   RefSeq; WP_002470820.1; NC_002976.3.
DR   AlphaFoldDB; Q5HLN7; -.
DR   STRING; 176279.SERP1948; -.
DR   EnsemblBacteria; AAW52830; AAW52830; SERP1948.
DR   KEGG; ser:SERP1948; -.
DR   eggNOG; COG4640; Bacteria.
DR   HOGENOM; CLU_047245_0_0_9; -.
DR   OMA; KEYCKAD; -.
DR   OrthoDB; 370861at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR023599; Mem_prot_TcaA.
DR   InterPro; IPR026870; Zinc_ribbon_dom.
DR   Pfam; PF13240; zinc_ribbon_2; 1.
DR   PIRSF; PIRSF032522; TcaA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..462
FT                   /note="Membrane-associated protein TcaA"
FT                   /id="PRO_0000333174"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..462
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         4..21
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  52417 MW;  B2F444551FBDC36D CRC64;
     MSQCPNCGHQ VKDDTSQCPN CGQLLTKKKK RKIKDQSSQS SNENSTNIRL RKIVPIGISV
     FILILIIVLF FLLRNYNSPN AQAKILVNAV DNNDSQKVAT LLSTKNKKVD DVEAQQYINY
     VKKEVGIKKY IRDINNTVDK LNKSNSSVAS YIQTKSGQDV LKISKNGTKY LIFDNMSFTA
     PTKKPIIKPK VETKYEFRTS GKKKTVIAEA NKNTPLGEFI PGTYHLPAKK ITENGTFNGH
     LNFDFRESHS ETVDVAEDYD QSFINIKFKG ANKLSDKSEK VQINDRTFTY SHSKEFGPYP
     KTKDITISAT GKAKGKTFSS ETKTISADDL KDNTKVTLEF DSDKINSYVE KKEKEENSLK
     NKLTEFFTGY ATAMNSAFNM NDFNFISSYF KKNSSIYTSM KSNFQNRTNV TMISPQVLSV
     HRNGHTVRTT IQHIDHIGNY INKDYELEID NDDSNMQLVK EL