TCAA_STAES
ID TCAA_STAES Reviewed; 462 AA.
AC Q8CN95;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Membrane-associated protein TcaA;
GN Name=tcaA; OrderedLocusNames=SE_1936;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Plays a major role in decreasing resistance to glycopeptide
CC antibiotics. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TcaA family. {ECO:0000305}.
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DR EMBL; AE015929; AAO05577.1; -; Genomic_DNA.
DR RefSeq; NP_765491.1; NC_004461.1.
DR RefSeq; WP_002470820.1; NZ_WBME01000027.1.
DR AlphaFoldDB; Q8CN95; -.
DR STRING; 176280.SE_1936; -.
DR EnsemblBacteria; AAO05577; AAO05577; SE_1936.
DR KEGG; sep:SE_1936; -.
DR PATRIC; fig|176280.10.peg.1889; -.
DR eggNOG; COG4640; Bacteria.
DR HOGENOM; CLU_047245_0_0_9; -.
DR OMA; KEYCKAD; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR023599; Mem_prot_TcaA.
DR InterPro; IPR026870; Zinc_ribbon_dom.
DR Pfam; PF13240; zinc_ribbon_2; 1.
DR PIRSF; PIRSF032522; TcaA; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell membrane; Membrane; Metal-binding;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..462
FT /note="Membrane-associated protein TcaA"
FT /id="PRO_0000333173"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..462
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT ZN_FING 4..21
FT /note="C4-type"
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 52417 MW; B2F444551FBDC36D CRC64;
MSQCPNCGHQ VKDDTSQCPN CGQLLTKKKK RKIKDQSSQS SNENSTNIRL RKIVPIGISV
FILILIIVLF FLLRNYNSPN AQAKILVNAV DNNDSQKVAT LLSTKNKKVD DVEAQQYINY
VKKEVGIKKY IRDINNTVDK LNKSNSSVAS YIQTKSGQDV LKISKNGTKY LIFDNMSFTA
PTKKPIIKPK VETKYEFRTS GKKKTVIAEA NKNTPLGEFI PGTYHLPAKK ITENGTFNGH
LNFDFRESHS ETVDVAEDYD QSFINIKFKG ANKLSDKSEK VQINDRTFTY SHSKEFGPYP
KTKDITISAT GKAKGKTFSS ETKTISADDL KDNTKVTLEF DSDKINSYVE KKEKEENSLK
NKLTEFFTGY ATAMNSAFNM NDFNFISSYF KKNSSIYTSM KSNFQNRTNV TMISPQVLSV
HRNGHTVRTT IQHIDHIGNY INKDYELEID NDDSNMQLVK EL