ID   TCAA_STAS1              Reviewed;         461 AA.
AC   Q49ZT3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Membrane-associated protein TcaA;
GN   Name=tcaA; OrderedLocusNames=SSP0546;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Plays a major role in decreasing resistance to glycopeptide
CC       antibiotics. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TcaA family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE17691.1; -; Genomic_DNA.
DR   RefSeq; WP_011302497.1; NZ_MTGA01000036.1.
DR   AlphaFoldDB; Q49ZT3; -.
DR   SMR; Q49ZT3; -.
DR   STRING; 342451.SSP0546; -.
DR   PRIDE; Q49ZT3; -.
DR   EnsemblBacteria; BAE17691; BAE17691; SSP0546.
DR   GeneID; 66866697; -.
DR   KEGG; ssp:SSP0546; -.
DR   eggNOG; COG4640; Bacteria.
DR   HOGENOM; CLU_047245_0_0_9; -.
DR   OMA; RTYNWTY; -.
DR   OrthoDB; 370861at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR023599; Mem_prot_TcaA.
DR   PIRSF; PIRSF032522; TcaA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..461
FT                   /note="Membrane-associated protein TcaA"
FT                   /id="PRO_0000333176"
FT   TOPO_DOM        1..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..461
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         4..21
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  52245 MW;  DBA11A8B1BA7AF5C CRC64;
     MRKCPKCGGN MRDKQSKCGH CGYEVTDNHS EQLTRSLKDN KKSANIKARK IIPWGIAFFI
     IILLIIIFFL LKNFNSPEAQ SELLINAVDN NDTQKLSTIL STQNNSVDET EATAYIKYIK
     NEVGMDNFVK DVNQKIKKLN ESETKEADFV TAKNGENVLR VSKNGRRYLI FDNMSFTAPT
     KEAIVKPKYD ATYKFKSDDK QKTVTAEKNK TTAIGKFIPG DYLLETKKET ANGQFDGQLK
     FNFNNSNNET IDVSEDFNEA YIQVELSGAS EIDKDTVKVK INDKTYDYAK AKEIGPYPKT
     NDITVSAEGE AKKKTFKSAE TTVKTDNLKD KTKVTLNFDD DEIQSYVDKK EKEENSFRNK
     VTNFFGNFTT AMNSAHSQSD FSLVSSYLKK NTDNYKSTKS DVNSNRLFFI QQPQITEIIK
     QGNTFYVTGQ ALKENGQYGE VDYQLQGDGD ADNLKVVKYS E