TCAB1_DROME
ID TCAB1_DROME Reviewed; 543 AA.
AC Q6NL34; Q960H9; Q9VMH1;
DT 12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Telomerase Cajal body protein 1 homolog {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 79 {ECO:0000303|PubMed:19285445};
GN Name=WDR79 {ECO:0000303|PubMed:19285445, ECO:0000312|FlyBase:FBgn0031782};
GN ORFNames=CG9226 {ECO:0000312|FlyBase:FBgn0031782};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, AND RNA-BINDING.
RX PubMed=19285445; DOI=10.1016/j.molcel.2009.02.020;
RA Tycowski K.T., Shu M.D., Kukoyi A., Steitz J.A.;
RT "A conserved WD40 protein binds the Cajal body localization signal of
RT scaRNP particles.";
RL Mol. Cell 34:47-57(2009).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24149844; DOI=10.1261/rna.042028.113;
RA Deryusheva S., Gall J.G.;
RT "Novel small Cajal-body-specific RNAs identified in Drosophila: probing
RT guide RNA function.";
RL RNA 19:1802-1814(2013).
CC -!- FUNCTION: RNA chaperone that plays a key role in Cajal body formation
CC (PubMed:24149844). Specifically recognizes and binds the Cajal body box
CC (CAB box) present in both small Cajal body RNAs (scaRNAs)
CC (PubMed:19285445). Probably acts by mediating localization of scaRNAs
CC to Cajal bodies (PubMed:24149844). {ECO:0000269|PubMed:19285445,
CC ECO:0000269|PubMed:24149844}.
CC -!- SUBCELLULAR LOCATION: Nucleus, Cajal body
CC {ECO:0000269|PubMed:24149844}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=C;
CC IsoId=Q6NL34-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q6NL34-2; Sequence=VSP_059806;
CC -!- SIMILARITY: Belongs to the TCAB1 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF52347.3; -; Genomic_DNA.
DR EMBL; AE014134; AHN54180.1; -; Genomic_DNA.
DR EMBL; AY052052; AAK93476.2; -; mRNA.
DR EMBL; BT012509; AAS93780.1; -; mRNA.
DR RefSeq; NP_001285665.1; NM_001298736.1. [Q6NL34-1]
DR RefSeq; NP_608997.3; NM_135153.4. [Q6NL34-2]
DR AlphaFoldDB; Q6NL34; -.
DR SMR; Q6NL34; -.
DR IntAct; Q6NL34; 3.
DR STRING; 7227.FBpp0305599; -.
DR PaxDb; Q6NL34; -.
DR PRIDE; Q6NL34; -.
DR DNASU; 33865; -.
DR EnsemblMetazoa; FBtr0333407; FBpp0305599; FBgn0031782. [Q6NL34-2]
DR EnsemblMetazoa; FBtr0346267; FBpp0312024; FBgn0031782. [Q6NL34-1]
DR GeneID; 33865; -.
DR KEGG; dme:Dmel_CG9226; -.
DR CTD; 33865; -.
DR FlyBase; FBgn0031782; WDR79.
DR VEuPathDB; VectorBase:FBgn0031782; -.
DR eggNOG; KOG2919; Eukaryota.
DR GeneTree; ENSGT00390000010169; -.
DR HOGENOM; CLU_022731_1_2_1; -.
DR OMA; FTKGCQW; -.
DR OrthoDB; 934297at2759; -.
DR PhylomeDB; Q6NL34; -.
DR BioGRID-ORCS; 33865; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33865; -.
DR PRO; PR:Q6NL34; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031782; Expressed in ovary and 10 other tissues.
DR ExpressionAtlas; Q6NL34; baseline and differential.
DR GO; GO:0015030; C:Cajal body; IDA:FlyBase.
DR GO; GO:0034512; F:box C/D RNA binding; IDA:FlyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0030576; P:Cajal body organization; IMP:FlyBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chaperone; Nucleus; Reference proteome; Repeat;
KW RNA-binding; WD repeat.
FT CHAIN 1..543
FT /note="Telomerase Cajal body protein 1 homolog"
FT /id="PRO_0000445072"
FT REPEAT 237..283
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 291..329
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 378..421
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REGION 95..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform B)"
FT /id="VSP_059806"
SQ SEQUENCE 543 AA; 60498 MW; FD49CC12CBE52F4A CRC64;
MIENSFKMEM HFKNRWQAAS LFLRYPRTVT LCLSGKSGDM DESVNLSTSM GDVEASMLNH
NVSFSSTMVT SNGDLSLPKL SVTLSAEEIL KLRSGRPKNA VESPHAGVPM ETSLAAEEEA
NGDEEEESVR VVDIEDTLEL TSNGNEAKPE DQELAIAPVL QYFQGALVEL GRRCWTSSTE
AQHYTKGCYW SPDGTCLLVP VHLDGMHVIE MPSDLYSADT VQPARSLTKL QSEVHVPEGG
TVYDCVWYPH MNSLQPETCL WLATRQHEPI HMWDAFDGSL RCSYSGYDAV DEVMAAISLA
FSHDGEQIYA GYKRCIKIFD TSRPGRFCDD YPVKFAISCI AQTTAHPHTL TCGNWHGYIQ
HFDLRCSHKQ GPLFTLGGHK GGITQLRYGE FGNGEWHLFS GARKCDKILQ WDMRNYKQPL
VELQRHVDTN QRIQFDLASD SNWLASGDTR GFVNVWDLKK YGDPSVLPLH SDCCNGVALN
PAMPILATSS GQFHFTDQSA QGDNVTLNGT ETTELPAPAD VNQNQKEVLY ENAVVMWWCG
QTG
