ID   TCAF1_BOVIN             Reviewed;         921 AA.
AC   A5PJN5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=TRPM8 channel-associated factor 1 {ECO:0000250|UniProtKB:Q9Y4C2};
DE   AltName: Full=TRP channel-associated factor 1 {ECO:0000250|UniProtKB:Q9Y4C2};
GN   Name=TCAF1 {ECO:0000250|UniProtKB:Q9Y4C2}; Synonyms=FAM115A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates the plasma membrane cation channel TRPM8
CC       activity. Involved in the recruitment of TRPM8 to the cell surface.
CC       Promotes prostate cancer cell migration inhibition in a TRPM8-dependent
CC       manner. {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SUBUNIT: Interacts with TRPM8 (via N-terminus and C-terminus domains);
CC       the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
CC       {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y4C2}.
CC       Note=Colocalizes with TRPM8 on the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- DOMAIN: The C-terminal region is necessary for the channel activity
CC       stimulation. {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SIMILARITY: Belongs to the TCAF family. {ECO:0000305}.
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DR   EMBL; BC142182; AAI42183.1; -; mRNA.
DR   RefSeq; NP_001092524.1; NM_001099054.1.
DR   AlphaFoldDB; A5PJN5; -.
DR   STRING; 9913.ENSBTAP00000050827; -.
DR   MEROPS; M98.A03; -.
DR   PaxDb; A5PJN5; -.
DR   PRIDE; A5PJN5; -.
DR   GeneID; 533126; -.
DR   KEGG; bta:533126; -.
DR   CTD; 9747; -.
DR   eggNOG; ENOG502S2AP; Eukaryota.
DR   InParanoid; A5PJN5; -.
DR   OrthoDB; 1049811at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:1901529; P:positive regulation of anion channel activity; IBA:GO_Central.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IBA:GO_Central.
DR   GO; GO:0010359; P:regulation of anion channel activity; IBA:GO_Central.
DR   Gene3D; 1.10.390.30; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR035423; M60-like_N.
DR   InterPro; IPR042279; Pep_M60_3.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF17291; M60-like_N; 1.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transport.
FT   CHAIN           1..921
FT                   /note="TRPM8 channel-associated factor 1"
FT                   /id="PRO_0000320181"
FT   DOMAIN          542..841
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
SQ   SEQUENCE   921 AA;  102125 MW;  7F559D94863F5690 CRC64;
     MATPSAAFEA LMNGVTSWNV PEDAVPCELL LIGEASFPVM VNDMGQVLIA ASSYGRGRLV
     VVSHEDYLVE AQLTPFLLNA VGWLCSSPGA PVGVHPSLAP LAKILEGSGV EAKVEPEVKD
     SLGVYCIDAY NETMTEKLVK FMKRGGGLLI GGQAWDWANQ GDDERVLFTF PGNLVTSVAG
     VYFTDNKGDT SFFKVSKKMP KIPVLVSCED DLSEDRDELL HGISELDITN SDCFPSQLLV
     HGALAFPLGL DSYHGCVIAA ARYGRGRVVV TGHKVLFTVG KLGPFLLNAV RWLDAGRRGK
     IVVQTELRTL SGLLAVGGID TSIEPNLTSD ASVYCFEPVS DVGVKELQEF VAEGGGLFVG
     AQAWWWAFKN PGVSPLARFP GNLLLNPFGI SITSQSLNPG PFRTPKAGIR TYHFRSTLAE
     FQVIMGRKRG NVEKGWLAKL GPDGAAFLQI PAEEIPAYMS VHRLLRKLLS RYRLPVATRE
     NPVINDCCRG AMLSLATGLA HSGSDLSLLV PEIEDMYSSP YLRPSESPIT VEVNCNNPGT
     RYCWMSTGLY IPGRQIIEVS LPEAAASADL KIQIGCHTDD LTRASKLFRG PLVINRCCLD
     KPTKSITCLW GGLLYIIVPQ SSKLGTVPVT IKGAVRAPYY KLGETTQEEW KRQIQENPGP
     WGELATDNII LTVPTANLRT LENPEPLLRL WDEVMQAVAR LGAEPFPLRL PQRIVADVQI
     SVGWMHAGYP IMCHLESVQE LINEKLIRTK GLWGPVHELG RNQQRQEWEF PPHTTEATCN
     LWCVYVHETV LGIPRGRANI ALWPPVREKR VRIYLGKGPN VKNWNAWTAL ETYLQLQEAF
     GWEPFIRLFT EYRNQTNLPT DNVDKMNLWV KMFSHQVQKN LAPFFEAWAW PIQKEVATSL
     AYLPEWEENI MKLYLLTQMP H