ID   TCAF1_PONAB             Reviewed;         921 AA.
AC   Q5R8R3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=TRPM8 channel-associated factor 1 {ECO:0000250|UniProtKB:Q9Y4C2};
DE   AltName: Full=TRP channel-associated factor 1 {ECO:0000250|UniProtKB:Q9Y4C2};
GN   Name=TCAF1 {ECO:0000250|UniProtKB:Q9Y4C2}; Synonyms=FAM115A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates the plasma membrane cation channel TRPM8
CC       activity. Involved in the recruitment of TRPM8 to the cell surface.
CC       Promotes prostate cancer cell migration inhibition in a TRPM8-dependent
CC       manner. {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SUBUNIT: Interacts with TRPM8 (via N-terminus and C-terminus domains);
CC       the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
CC       {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y4C2}.
CC       Note=Colocalizes with TRPM8 on the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- DOMAIN: The C-terminal region is necessary for the channel activity
CC       stimulation. {ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SIMILARITY: Belongs to the TCAF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH91847.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR859688; CAH91847.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001126070.1; NM_001132598.1.
DR   AlphaFoldDB; Q5R8R3; -.
DR   STRING; 9601.ENSPPYP00000020335; -.
DR   MEROPS; M98.A03; -.
DR   GeneID; 100173022; -.
DR   KEGG; pon:100173022; -.
DR   CTD; 9747; -.
DR   eggNOG; ENOG502S2AP; Eukaryota.
DR   InParanoid; Q5R8R3; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.390.30; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR035423; M60-like_N.
DR   InterPro; IPR042279; Pep_M60_3.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF17291; M60-like_N; 1.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transport.
FT   CHAIN           1..921
FT                   /note="TRPM8 channel-associated factor 1"
FT                   /id="PRO_0000320184"
FT   DOMAIN          542..841
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
SQ   SEQUENCE   921 AA;  102220 MW;  7CF9D2989FE3ECA9 CRC64;
     MATPSAAFEA LMNGVTSWDV PEDAVPCELL LIGEASFPVM VNDMGQVLIA TSSYGRGRLV
     VVSHEDYLVE AQLTPFLLNA VGWLCSSPGA PIGVHPSLAP LAKILEGSGV DAKVEPEVKD
     SLGVYCIDAY NETMTEKLVK FMKRGGGLLI GGQAWDWANQ GEDERVLFTF PGNLVTSVAG
     IYFTDNKGDT SFFKVSKKMP KIPVLVSCED DLSEDREELL HGISELDISN SDCFPSQLLV
     HGALAFPLGL DSYHGCVIAA ARYGRGRVVV TGHKVLFTVG KLGPFLLNAV RWLDGGRRGK
     VVVQTELRTL SGLLAVGGID TSIEPNLTSD ASVYCFEPVS EVGVKELQEF VAEGGGLFVG
     AQAWWWAFKN PGVSPLARFP GNLLLNPFGI SITSQSLNPG PFRTPKAGIR TYHFRSTLAE
     FQVIMGRKRG NVEKGWLAKL GPDGAAFLQI PAEEIPAYMS VHRLLRKLLS RYRLPVATRE
     NPVINDCCRG AMLSLATGLA HSGSDLSLLV PEIEDMYSSP YLRPSESPIT VEVNCTNPGT
     RYCWMSTGLY IPGRQIIEVS LPEAAASADL KIQIGCHTDD LTRASKLFRG PLVINRCCLD
     KPTKSITCLW GGLLYIIVPQ NSKLGSVPVT VKGAVHAPYY KLGETTLEEW KRHIQENPGP
     WGELATDNII LTVPTANLRT LENPEPLLRL WDEVMQAVAR LGAEPFPLRL PQRIVADVQI
     SVGWMHAGYP IMCHLESVQE LINEKLIRTK GLWGPVHELG RNQQRQEWEF PPHTTEATCN
     LWCVYVHETV LGIPRSRANI ALWPPVREKR VRIYLSKGPN VKNWNAWTAL ETYLQLQEAF
     GWEPFIRLFT EYRNQTNLPT DNVDKMNLWV KMFSHQVQKN LAPFFEAWAW PIQKEVTTSL
     AYLPEWKENI MKLYLLTQMP H