ID   TCAF3_MOUSE             Reviewed;         914 AA.
AC   Q6QR59;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=TRPM8 channel-associated factor 3 {ECO:0000312|MGI:MGI:3042585};
DE   AltName: Full=Experimental autoimmune prostatitis antigen 2;
GN   Name=Tcaf3 {ECO:0000312|MGI:MGI:3042585}; Synonyms=Eapa2, Fam115e;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], ANTIGEN, AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=16223778; DOI=10.1182/blood-2005-08-3088;
RA   Setiady Y.Y., Ohno K., Samy E.T., Bagavant H., Qiao H., Sharp C., She J.X.,
RA   Tung K.S.K.;
RT   "Physiologic self antigens rapidly capacitate autoimmune disease-specific
RT   polyclonal CD4+ CD25+ regulatory T cells.";
RL   Blood 107:1056-1062(2006).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND TISSUE SPECIFICITY.
RX   PubMed=17003280; DOI=10.1677/joe.1.06733;
RA   Fujimoto N., Akimoto Y., Suzuki T., Kitamura S., Ohta S.;
RT   "Identification of prostatic-secreted proteins in mice by mass
RT   spectrometric analysis and evaluation of lobe-specific and androgen-
RT   dependent mRNA expression.";
RL   J. Endocrinol. 190:793-803(2006).
CC   -!- FUNCTION: May play a role in the regulation of the cation channel TRPM8
CC       activity. {ECO:0000250|UniProtKB:A6NFQ2, ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- TISSUE SPECIFICITY: Prostate-specific. Present in both dorso-lateral
CC       and anterior prostate. {ECO:0000269|PubMed:16223778,
CC       ECO:0000269|PubMed:17003280}.
CC   -!- MISCELLANEOUS: May act as an autoantigen in prostate autoimmunity.
CC   -!- SIMILARITY: Belongs to the TCAF family. {ECO:0000305}.
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DR   EMBL; AY528666; AAS18676.1; -; mRNA.
DR   CCDS; CCDS20074.1; -.
DR   RefSeq; NP_981933.1; NM_203396.1.
DR   AlphaFoldDB; Q6QR59; -.
DR   STRING; 10090.ENSMUSP00000064060; -.
DR   MEROPS; M98.A03; -.
DR   PaxDb; Q6QR59; -.
DR   PRIDE; Q6QR59; -.
DR   ProteomicsDB; 263085; -.
DR   DNASU; 403088; -.
DR   Ensembl; ENSMUST00000069023; ENSMUSP00000064060; ENSMUSG00000018656.
DR   GeneID; 403088; -.
DR   KEGG; mmu:403088; -.
DR   UCSC; uc009brm.1; mouse.
DR   CTD; 403088; -.
DR   MGI; MGI:3042585; Tcaf3.
DR   VEuPathDB; HostDB:ENSMUSG00000018656; -.
DR   eggNOG; ENOG502QQUS; Eukaryota.
DR   GeneTree; ENSGT00390000017365; -.
DR   HOGENOM; CLU_011215_0_0_1; -.
DR   InParanoid; Q6QR59; -.
DR   OMA; CGVCPWG; -.
DR   OrthoDB; 1049811at2759; -.
DR   PhylomeDB; Q6QR59; -.
DR   TreeFam; TF331520; -.
DR   BioGRID-ORCS; 403088; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Tcaf3; mouse.
DR   PRO; PR:Q6QR59; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q6QR59; protein.
DR   Bgee; ENSMUSG00000018656; Expressed in cerebellar cortex and 3 other tissues.
DR   ExpressionAtlas; Q6QR59; differential.
DR   GO; GO:0030054; C:cell junction; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR   GO; GO:0010360; P:negative regulation of anion channel activity; ISO:MGI.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISO:MGI.
DR   GO; GO:0010359; P:regulation of anion channel activity; IBA:GO_Central.
DR   Gene3D; 1.10.390.30; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR035423; M60-like_N.
DR   InterPro; IPR042279; Pep_M60_3.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF17291; M60-like_N; 1.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..914
FT                   /note="TRPM8 channel-associated factor 3"
FT                   /id="PRO_0000320191"
FT   DOMAIN          533..832
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
SQ   SEQUENCE   914 AA;  102243 MW;  E3D1722BC8EF2D73 CRC64;
     MATTPDAAFE TLMNGVTSWD LPKEPIPSEL LLTGESAFPV MVNDKGQVLI AASSYGQGRL
     VVVSHESYLL HDGLVPFLLN VVKWLCPCPG APIAVHSSLA SLVNILGDSG INALVQPEPG
     EALGVYCIDA YNDALTEKLI QFLKNGGGLL IGGQALNWAA HHGHDKVLSI FPGNQVTSVA
     GVYFTDISAN RDWFKVSKEI PNLRLYVQCE DELEDDQQQL LKGMSEIYIE AGVIPSQLLV
     HGQRAFPLGV DNSLNCFLAA ARYGRGRVVL GGNESLILNQ TMLPFVLNAL HWLMGNQTGR
     IGLASDMKVL KSMLPNSSFQ WSESELLTSD LSVFCCCSLA NIDSEEVEEF VAEGGGLLIG
     AEAWSWGRRN PYSSCMTQYP DNIVLKRFGL GITSHVAQRG SFPFPNPEGT NYHFRRALSQ
     FESVIYSRGS SLHESWLNKL SQDCFYMFQM THQRISIYDS VKKHALKMIQ SKDFPSVTEQ
     YPIARGSSQA FLLSLAYELF KSGVDRSQLL PPPALLPPTE SPITIKISTD NDNSWVSTGL
     YLPEGQVAQV LLPSEATHAK LKVLIGCHRD NISQARTYFR PPVMTYVYHL TSSQTSISWL
     YGGLLYIMVP NKYNQDNVSV TIRGAVSAPY FRLGKTTQEE WKNLITHSKA PWGELATDNI
     ILTIPTVNLK ELQDPYPLLQ LWDKMVRAVA KLAARPFPFQ RAERVVLDKQ ISFGFLHSGY
     PIMGLISIVE GIISEFKIRS HGIWGVIHEL GHNHQKSGWT FPPHTTEALC NLWTIYVHET
     VLNIPREQAH PSLNPELRRQ RIKYHLNKGA PLSNWIMWTA LETYLQLQEG FGWEPFIQVF
     ADYRTLSGLP QNNEDKMNLW VKKFSEAVHK NLAPFFEAWG WPVKYAVAKS LASLPEWQEN
     PMKRYTAEGT EGRE