ID   TCAF3_RAT               Reviewed;         914 AA.
AC   Q6P6V7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=TRPM8 channel-associated factor 3 {ECO:0000305};
DE   AltName: Full=Experimental autoimmune prostatitis antigen 2 homolog;
GN   Name=Tcaf3 {ECO:0000305}; Synonyms=Eapa2, Fam115e;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in the regulation of the cation channel TRPM8
CC       activity. {ECO:0000250|UniProtKB:A6NFQ2, ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SIMILARITY: Belongs to the TCAF family. {ECO:0000305}.
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DR   EMBL; BC061995; AAH61995.1; -; mRNA.
DR   RefSeq; NP_001009534.1; NM_001009534.1.
DR   AlphaFoldDB; Q6P6V7; -.
DR   STRING; 10116.ENSRNOP00000056152; -.
DR   MEROPS; M98.A03; -.
DR   PaxDb; Q6P6V7; -.
DR   GeneID; 494321; -.
DR   KEGG; rno:494321; -.
DR   UCSC; RGD:1359405; rat.
DR   CTD; 494321; -.
DR   RGD; 1359405; Fam115e.
DR   eggNOG; ENOG502QQUS; Eukaryota.
DR   InParanoid; Q6P6V7; -.
DR   OrthoDB; 1049811at2759; -.
DR   PhylomeDB; Q6P6V7; -.
DR   PRO; PR:Q6P6V7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0010360; P:negative regulation of anion channel activity; IBA:GO_Central.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IBA:GO_Central.
DR   GO; GO:0010359; P:regulation of anion channel activity; IBA:GO_Central.
DR   Gene3D; 1.10.390.30; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR035423; M60-like_N.
DR   InterPro; IPR042279; Pep_M60_3.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF17291; M60-like_N; 1.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..914
FT                   /note="TRPM8 channel-associated factor 3"
FT                   /id="PRO_0000320192"
FT   DOMAIN          533..832
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
SQ   SEQUENCE   914 AA;  102094 MW;  CFF352756FD63174 CRC64;
     MATTPDAAFE ALMNGVTSWN LPKEPTPSEL LLTGEAAFPV MVNDKDQVLI AASFYGHGRL
     VVLSHESYLL HAGLAPFLLN AVSWLCPSPE APIAVHSSLA SLVKILGDSG VNAVVQPEPR
     EALGVYCIDA YSETLTETLI RFMKNGGGLL IGGQALTWAV HHGHEKVLSS FPGNQVTSVA
     GVYFTDISGN RDWFKVSKEI PNLTLYVQCE DELKYDQQQL LKGMSEMDIE TGPVPSQLLV
     HGQRAFPLGV DNSFNCFLAA ARFGRGRVVL AGHESLILNQ TMLPFVLNAL RWLMGNQTGR
     IGLASEMKAL KSVLPNSSFE WSETELLTND LSVFCSCSLG KTDPKKVEEF VAEGGGLLIG
     AEAWMWGRRN PDSNCMTQYP NNIILKRFGV GIISQVVQRG RFPVPNPEVI NYHIRRALSQ
     YESVIHSQGS SLQEGWLNKL SQDCFYMFQM THQRISIYDS VKEHALKMIQ SQGFPSVTEQ
     HPITKGSSQA FLLSLAYELF KSGVDRSQLL PPPTLLSPTE SPMTIKISTG NDNSWVSTGL
     YLPEGQVAQV TLPTEATHAK LKVLIGCHID NISQAKTYIR PPVMTYVYHL TSSQTSISWL
     YGGLLYIMVP DKYNQDNVSV TISGAVSAPY FRLGKTTQEE WKNLIEHSKA PWGELATDNI
     ILTIPTVNLK VLQDPYPLLQ LWDKIVKAVA KLAARPFPFQ RPERIVLDKQ ISFGFLHSGY
     PIMGLIIIVE GIINEFKIRS HGVWGVTHEL GHNHQKPGWT FRPHTTEALC NLWSIYVHET
     VLNIPRDQAH PSLNPELRKQ RIKDHLNKGA PLSNWIVWTA LETYLQLQEG FGWEPFIQLF
     ANYQTLTGLP QNNEDKMNLW VKKFSEVVQK NLAPFFKAWG WPVQHAVAKS LASLPEWQEN
     PMKMYTAEST EHTE