ID   TCAF_DANRE              Reviewed;         912 AA.
AC   A4IG42;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=TRPM8 channel-associated factor homolog;
GN   Name=tcaf; ORFNames=zgc:162193;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of the cation channel TRPM8
CC       activity. {ECO:0000250|UniProtKB:A6NFQ2, ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SIMILARITY: Belongs to the TCAF family. {ECO:0000305}.
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DR   EMBL; BC134919; AAI34920.1; -; mRNA.
DR   RefSeq; NP_001082796.1; NM_001089327.1.
DR   AlphaFoldDB; A4IG42; -.
DR   STRING; 7955.ENSDARP00000111062; -.
DR   MEROPS; M98.A01; -.
DR   PaxDb; A4IG42; -.
DR   PeptideAtlas; A4IG42; -.
DR   GeneID; 323315; -.
DR   KEGG; dre:323315; -.
DR   ZFIN; ZDB-GENE-030131-2035; zgc:162193.
DR   eggNOG; ENOG502QQUS; Eukaryota.
DR   InParanoid; A4IG42; -.
DR   OrthoDB; 1049811at2759; -.
DR   PhylomeDB; A4IG42; -.
DR   PRO; PR:A4IG42; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IBA:GO_Central.
DR   GO; GO:0010359; P:regulation of anion channel activity; IBA:GO_Central.
DR   Gene3D; 1.10.390.30; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR035423; M60-like_N.
DR   InterPro; IPR042279; Pep_M60_3.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF17291; M60-like_N; 1.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..912
FT                   /note="TRPM8 channel-associated factor homolog"
FT                   /id="PRO_0000320189"
FT   DOMAIN          539..838
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
SQ   SEQUENCE   912 AA;  100984 MW;  235FF66A206D993A CRC64;
     MAREQDYYTL MSGMQQLDLQ GKAVPSDLVL IGEHAFPLAM NPRGQVLMAA SHYGRGRIVV
     LGHEEYLTRF PGLIENAIMW LMPCTGDAGV VGIQKSLRTV AENLNYSPFK TELGDFQDRF
     AIYITDAYSV ESSAKDLIAF LKAGGGLIIA GQAWSWSYEH PQENTIRNFP GNKVCSVAGI
     YFSELEGEVG TFPVPRNIPS SWLAVAIGKD FKEDLEFLLE GVSEFDTQGG AIASEVMVHG
     PLAFPIAVTP NGKTFIAGAY YGQGRVIVVS HEGYMGRDSL SSFMINAIKW LDEGRKGVVG
     IVPNLTAAHT VLSKSGLDCQ LTGFREDLSV YVCTSYSDAQ CAEIQEFVAE GGGLLIGGHA
     WYWAQTHCGS NVMTEYPGNH ILNKMGLCLL GNTLGGGLYK APEIEHSCKH GYHFRSMLQR
     FAQHVSQGQE LTDREQGCLK QLGTDCASYL QMRCHDSAAY TSVVALLSDI VKEVGVPQVC
     SNCPVESPKD HLMLHIGTEV YKVTPDPDAL LPYIIKDRPN LPTLSNARVR ITANTGGCEE
     WISTGLYLSP GMKTYIAVPP EIVGKNWQVQ LGCQTDNIGG SNTLKRAPVV HARFPLDSEM
     VQVWNLWGGL IYLIAPSQTK VDGVEIVVQN AVQAPYFKSG ETSVADWVSH IRQAPAPWAE
     LEFENLIMTF DSAFIRNLDR PDEVAKLWDT IMRTITDLAA RPPKLPRKER FVADVQISYG
     FMHAGYPIMM HSGSAPGLVN VEEAYKCGLW GAIHELGHNQ QRGVWEFPPH TTECTCNLWS
     LYVHEQVFGI KSANAHPAIT PADRQARTKM YFDGGKDLNS WCMWMALETY MQLQEKFGWD
     AFKKVFSLYH DMTGVPNDNA GKMNLYAQTF SKVVNLNLSP FFKAWGWPIQ PNTEQNLSHL
     PAWSDHPVSQ YA