ID   TCAF_XENLA              Reviewed;         905 AA.
AC   Q5XHI4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=TRPM8 channel-associated factor homolog;
DE   AltName: Full=TRPM8 channel-associated factor 1;
GN   Name=tcaf; Synonyms=tcaf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of the cation channel TRPM8
CC       activity. {ECO:0000250|UniProtKB:A6NFQ2, ECO:0000250|UniProtKB:Q9Y4C2}.
CC   -!- SIMILARITY: Belongs to the TCAF family. {ECO:0000305}.
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DR   EMBL; BC084073; AAH84073.1; -; mRNA.
DR   RefSeq; NP_001088165.1; NM_001094696.1.
DR   AlphaFoldDB; Q5XHI4; -.
DR   PRIDE; Q5XHI4; -.
DR   DNASU; 494989; -.
DR   GeneID; 494989; -.
DR   KEGG; xla:494989; -.
DR   CTD; 494989; -.
DR   Xenbase; XB-GENE-6078820; tcaf1.L.
DR   OMA; MQIPSSW; -.
DR   OrthoDB; 1049811at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 494989; Expressed in neurula embryo and 4 other tissues.
DR   Gene3D; 1.10.390.30; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR035423; M60-like_N.
DR   InterPro; IPR042279; Pep_M60_3.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF17291; M60-like_N; 1.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   SUPFAM; SSF52317; SSF52317; 2.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..905
FT                   /note="TRPM8 channel-associated factor homolog"
FT                   /id="PRO_0000320190"
FT   DOMAIN          524..823
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
SQ   SEQUENCE   905 AA;  100737 MW;  9D3567BC46C48700 CRC64;
     MKVLEDYRSL VHGIGSLDFS GDAVPCKLLL TGDTAFPVLV TPRKDVLIAA SRYGKGKVVV
     MAHESYLNTN AFMDFLKNAV SWLSPNSEAN IGVHKGLNLL TDNLSANGSK VQNTSTLIEG
     LGVFCTIGYD DSQDKQIISF VREGGGLLIG AQAWHWSYSH KQENVLHHFP GNKIISVSGV
     HFTSDYGEKG NICVMENIPQ APIYTSFDFS LDQKYLLKGM SQLDISGSSI PSDLLLHGTL
     SFPVGLSENK QCFLGATYYG KGRVVVATHE GYLSKSELKT IMLNAISWLD INQNRRIGVH
     KGLRQFAELL QKENIPCNIS SLDPDLSVYC CTSYSDAEAK AIHEFVAEGG GLLIAGHAWY
     WSSQNSDLDV LIQYPGNKIL NKFGISILDR TIPGGNYNAI NPDESSQQYH FRRGLCNLQA
     ELRSGAEVKP PLSIWMNKLR QDVTAFMRLP ANPIISSIQS QFVEMMQICE IPNVTKQCPV
     SSCSKEAFIL CLAQECFNVC DESHILEKEP SITVEIDGTN PGNNAWRSTG LYLAPRKTAV
     LEFPASAVHQ GLQVQVGCQS DDLSSADKYC RAPVVVRRFH VDSQRVSVSC FWGGLVYITV
     KANSNLGIIP VKVYEAEPAP IYIKGKTSLD TWIQSIRNLP APWAELITEN IILTVPSDAI
     RSLSDPEALL SLWDKIMVAI TELAAIPKKL PRPERFVADV QISAGWMHAG YPIMCHLESA
     KELTDLNIMQ TGGIWGPIHE LGHNQQKTNW ELPPHTTEAT CNLWSVYVHE TVLGIPRSQA
     HCCLQAETRA NHIQEYLRNG SNIEQWNVWT ALETYLQLQE GFGWEPFKQL FKDYQSMSGI
     RNENKSKMNL WAEKFSEAVQ TNLVPFFEAW GWPIEEATHS KLSVLPVWEK DPMKSYLSAR
     KSNSN