TCAIM_HUMAN
ID TCAIM_HUMAN Reviewed; 496 AA.
AC Q8N3R3; A8K9P1; Q0P5T9; Q495R1; Q495R3; Q4G0M4; Q6GMU8;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=T-cell activation inhibitor, mitochondrial;
DE AltName: Full=Tolerance associated gene-1 protein;
DE Short=TOAG-1;
GN Name=TCAIM; Synonyms=C3orf23, TOAG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Esophageal carcinoma, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adipose tissue;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC TISSUE=Brain, Hippocampus, Leukocyte, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May regulate T-cell apoptosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N3R3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N3R3-2; Sequence=VSP_018471, VSP_018472;
CC Name=3;
CC IsoId=Q8N3R3-3; Sequence=VSP_018469, VSP_018470;
CC Name=4;
CC IsoId=Q8N3R3-4; Sequence=VSP_038421;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AK292756; BAF85445.1; -; mRNA.
DR EMBL; AK056593; BAG51758.1; -; mRNA.
DR EMBL; AK124087; BAG54004.1; -; mRNA.
DR EMBL; AL832473; CAD38627.1; -; mRNA.
DR EMBL; AC104187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC134943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW64703.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW64704.1; -; Genomic_DNA.
DR EMBL; BC009400; AAH09400.2; -; mRNA.
DR EMBL; BC038420; AAH38420.1; -; mRNA.
DR EMBL; BC047231; AAH47231.1; -; mRNA.
DR EMBL; BC062587; AAH62587.1; -; mRNA.
DR EMBL; BC073829; AAH73829.1; -; mRNA.
DR EMBL; BC101059; AAI01060.1; -; mRNA.
DR EMBL; BC101061; AAI01062.1; -; mRNA.
DR EMBL; BC101058; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC101060; AAI01061.1; -; mRNA.
DR CCDS; CCDS2712.1; -. [Q8N3R3-1]
DR CCDS; CCDS43076.1; -. [Q8N3R3-3]
DR RefSeq; NP_001025010.1; NM_001029839.2. [Q8N3R3-3]
DR RefSeq; NP_001025011.1; NM_001029840.2. [Q8N3R3-3]
DR RefSeq; NP_001269842.1; NM_001282913.1. [Q8N3R3-1]
DR RefSeq; NP_001269843.1; NM_001282914.1. [Q8N3R3-4]
DR RefSeq; NP_001269844.1; NM_001282915.1. [Q8N3R3-4]
DR RefSeq; NP_776187.2; NM_173826.3. [Q8N3R3-1]
DR RefSeq; XP_016861740.1; XM_017006251.1.
DR AlphaFoldDB; Q8N3R3; -.
DR BioGRID; 130085; 5.
DR IntAct; Q8N3R3; 1.
DR STRING; 9606.ENSP00000341539; -.
DR iPTMnet; Q8N3R3; -.
DR PhosphoSitePlus; Q8N3R3; -.
DR BioMuta; TCAIM; -.
DR DMDM; 116241286; -.
DR EPD; Q8N3R3; -.
DR jPOST; Q8N3R3; -.
DR MassIVE; Q8N3R3; -.
DR MaxQB; Q8N3R3; -.
DR PaxDb; Q8N3R3; -.
DR PeptideAtlas; Q8N3R3; -.
DR PRIDE; Q8N3R3; -.
DR ProteomicsDB; 71823; -. [Q8N3R3-1]
DR ProteomicsDB; 71824; -. [Q8N3R3-2]
DR ProteomicsDB; 71826; -. [Q8N3R3-4]
DR Antibodypedia; 53088; 73 antibodies from 11 providers.
DR DNASU; 285343; -.
DR Ensembl; ENST00000342649.9; ENSP00000341539.4; ENSG00000179152.20. [Q8N3R3-1]
DR Ensembl; ENST00000383746.7; ENSP00000373252.3; ENSG00000179152.20. [Q8N3R3-3]
DR Ensembl; ENST00000396078.7; ENSP00000379388.3; ENSG00000179152.20. [Q8N3R3-3]
DR Ensembl; ENST00000412611.6; ENSP00000392032.2; ENSG00000179152.20. [Q8N3R3-2]
DR Ensembl; ENST00000417237.5; ENSP00000402581.1; ENSG00000179152.20. [Q8N3R3-1]
DR Ensembl; ENST00000417768.1; ENSP00000402604.1; ENSG00000179152.20. [Q8N3R3-2]
DR Ensembl; ENST00000431657.5; ENSP00000387842.1; ENSG00000179152.20. [Q8N3R3-2]
DR GeneID; 285343; -.
DR KEGG; hsa:285343; -.
DR MANE-Select; ENST00000342649.9; ENSP00000341539.4; NM_173826.4; NP_776187.2.
DR UCSC; uc003cnb.5; human. [Q8N3R3-1]
DR CTD; 285343; -.
DR DisGeNET; 285343; -.
DR GeneCards; TCAIM; -.
DR HGNC; HGNC:25241; TCAIM.
DR HPA; ENSG00000179152; Tissue enhanced (liver).
DR neXtProt; NX_Q8N3R3; -.
DR OpenTargets; ENSG00000179152; -.
DR PharmGKB; PA142672384; -.
DR VEuPathDB; HostDB:ENSG00000179152; -.
DR eggNOG; ENOG502QTGC; Eukaryota.
DR GeneTree; ENSGT00390000012832; -.
DR HOGENOM; CLU_2757111_0_0_1; -.
DR InParanoid; Q8N3R3; -.
DR OMA; HISHYYS; -.
DR OrthoDB; 849169at2759; -.
DR PhylomeDB; Q8N3R3; -.
DR TreeFam; TF315619; -.
DR PathwayCommons; Q8N3R3; -.
DR SignaLink; Q8N3R3; -.
DR BioGRID-ORCS; 285343; 12 hits in 1084 CRISPR screens.
DR ChiTaRS; TCAIM; human.
DR GeneWiki; C3orf23; -.
DR GenomeRNAi; 285343; -.
DR Pharos; Q8N3R3; Tbio.
DR PRO; PR:Q8N3R3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N3R3; protein.
DR Bgee; ENSG00000179152; Expressed in right lobe of liver and 180 other tissues.
DR ExpressionAtlas; Q8N3R3; baseline and differential.
DR Genevisible; Q8N3R3; HS.
DR GO; GO:0005739; C:mitochondrion; IDA:LIFEdb.
DR InterPro; IPR028031; DUF4460.
DR InterPro; IPR027989; DUF4461.
DR InterPro; IPR027986; TCAIM.
DR PANTHER; PTHR31596; PTHR31596; 1.
DR Pfam; PF14687; DUF4460; 1.
DR Pfam; PF14688; DUF4461; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Mitochondrion; Reference proteome.
FT CHAIN 1..496
FT /note="T-cell activation inhibitor, mitochondrial"
FT /id="PRO_0000235340"
FT COILED 404..437
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..144
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_038421"
FT VAR_SEQ 56..70
FT /note="EINENSLKRLSVYLE -> DDTWKSFQCPSDFSL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_018469"
FT VAR_SEQ 71..496
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_018470"
FT VAR_SEQ 107..115
FT /note="GFRAVKFTL -> VYLLNISKA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018471"
FT VAR_SEQ 116..496
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018472"
FT VARIANT 4
FT /note="H -> P (in dbSNP:rs35830741)"
FT /id="VAR_050720"
FT CONFLICT 3
FT /note="C -> Y (in Ref. 1; BAF85445)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="S -> G (in Ref. 2; CAD38627)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 496 AA; 57925 MW; A4D60B8606F58251 CRC64;
MFCHLRPMRR LCLEKIFPHW FPFSRALSGA EAVNALRPFY FAVHPDFFGQ HPVEREINEN
SLKRLSVYLE NLQKPGFKSL KPTQLTFYVR ETDQSSSDGQ EPFSTSGFRA VKFTLHTRDL
LSTVLYILNS CSLSVEHIQS LNTNMHTQPL KEAKRMPDRP IKWDKSYYSF TGFKDPDEDL
EQVSRVETTL TSWLDNNGKS AVKKLKNSLP LRKELDRLKD ELSHQLQLSD IRWQRSWGIA
HRCSQLHSLS RLAQQNLETL KKAKGCTIIF TDRSGMSAVG HVMLGTMDVH HHWTKLFERL
PSYFDLQRRL MILEDQISYL LGGIQVVYIE ELQPVLTLEE YYSLLDVFYN RLLKSRILFH
PRSLRGLQMI LNSDRYAPSL HELGHFNIPT LCDPANLQWF ILTKAQQARE NMKRKEELKV
IENELIQAST KKFSLEKLYK EPSISSIQMV DCCKRLLEQS LPYLHGMHLC ISHFYSVMQD
GDLCIPWNWK NGEAIK
