ID   TCAIM_MOUSE             Reviewed;         499 AA.
AC   Q66JZ4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=T-cell activation inhibitor, mitochondrial;
DE   AltName: Full=Tolerance associated gene-1 protein;
DE            Short=TOAG-1;
GN   Name=TCAIM; Synonyms=D9Ertd402e, Toag1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic germ cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=17456197; DOI=10.1111/j.1600-6143.2007.01768.x;
RA   Sawitzki B., Bushell A., Steger U., Jones N., Risch K., Siepert A.,
RA   Lehmann M., Schmitt-Knosalla I., Vogt K., Gebuhr I., Wood K., Volk H.D.;
RT   "Identification of gene markers for the prediction of allograft rejection
RT   or permanent acceptance.";
RL   Am. J. Transplant. 7:1091-1102(2007).
RN   [3]
RP   PUTATIVE FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19684086; DOI=10.4049/jimmunol.0804351;
RA   Keeren K., Friedrich M., Gebuhr I., Philipp S., Sabat R., Sterry W.,
RA   Brandt C., Meisel C., Grutz G., Volk H.D., Sawitzki B.;
RT   "Expression of tolerance associated gene-1, a mitochondrial protein
RT   inhibiting T cell activation, can be used to predict response to immune
RT   modulating therapies.";
RL   J. Immunol. 183:4077-4087(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May regulate T-cell apoptosis.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19684086}.
CC   -!- TISSUE SPECIFICITY: Expressed in peripheral blood leukocytes, mainly in
CC       T-lymphocytes. {ECO:0000269|PubMed:17456197}.
CC   -!- INDUCTION: Up-regulated during induction and maintenance of graft
CC       acceptance and down-regulated during graft rejection.
CC       {ECO:0000269|PubMed:17456197}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC080690; AAH80690.1; -; mRNA.
DR   RefSeq; NP_001013423.2; NM_001013405.2.
DR   AlphaFoldDB; Q66JZ4; -.
DR   STRING; 10090.ENSMUSP00000049759; -.
DR   PhosphoSitePlus; Q66JZ4; -.
DR   MaxQB; Q66JZ4; -.
DR   PaxDb; Q66JZ4; -.
DR   PRIDE; Q66JZ4; -.
DR   ProteomicsDB; 263019; -.
DR   GeneID; 382117; -.
DR   KEGG; mmu:382117; -.
DR   CTD; 285343; -.
DR   MGI; MGI:1196217; Tcaim.
DR   eggNOG; ENOG502QTGC; Eukaryota.
DR   InParanoid; Q66JZ4; -.
DR   OrthoDB; 849169at2759; -.
DR   PhylomeDB; Q66JZ4; -.
DR   BioGRID-ORCS; 382117; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q66JZ4; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q66JZ4; protein.
DR   GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR   InterPro; IPR028031; DUF4460.
DR   InterPro; IPR027989; DUF4461.
DR   InterPro; IPR027986; TCAIM.
DR   PANTHER; PTHR31596; PTHR31596; 1.
DR   Pfam; PF14687; DUF4460; 1.
DR   Pfam; PF14688; DUF4461; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Mitochondrion; Reference proteome.
FT   CHAIN           1..499
FT                   /note="T-cell activation inhibitor, mitochondrial"
FT                   /id="PRO_0000235341"
FT   COILED          206..233
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  57402 MW;  C169EE62F2CF6278 CRC64;
     MFCHLRPLRR FGLRKVLPHW LHYSRALSGA EAINALRPFY FAVHPDFFGQ HPREREVNEN
     SLKRLSVYLE NLQKPGFKSL KPTQLTFYIR EKTAQNSSEG QEPISTTGFR AVRFTLHSSD
     LLSTVLYILN SCSLPVEHVQ SLNTNVHSQP LKEATGMPDR PIKWHRSYYS FTGFKDPDED
     LTHVSRVETT LTSWLGSNGK GAVKKLRNSL PLRKELDRLK NELSELLQLS DIRWQRGWGV
     AHRCSQLHSL SRLAQQNPGP LQNVKGCTVV FTDRSGMSAL GHVMLGTMDV HHHWTRLFES
     LPSYFDLQRR MSALEAQISN LLGGIQVVYI EELQPALTLD QYYSLLHTFY NQLLRSRVPP
     HPHPQSLSGL QMILSSDRYA PSLHELGHFD IPALSDPASL QSFMRTKAQQ ARENMTRREK
     LKVMENELIQ ASTKQFSLEK LYKEPSISSR QMVDCCKRLL EQSLPYLHGM HLCVSHFYSV
     MQDGDLCIPW NWKKGEAMK