ID   TCAIM_RAT               Reviewed;         505 AA.
AC   P0DKR2; A6I484;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=T-cell activation inhibitor, mitochondrial;
DE   AltName: Full=Tolerance-associated gene-1;
DE            Short=TOAG-1;
GN   Name=Tcaim; Synonyms=Toag1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=17456197; DOI=10.1111/j.1600-6143.2007.01768.x;
RA   Sawitzki B., Bushell A., Steger U., Jones N., Risch K., Siepert A.,
RA   Lehmann M., Schmitt-Knosalla I., Vogt K., Gebuhr I., Wood K., Volk H.D.;
RT   "Identification of gene markers for the prediction of allograft rejection
RT   or permanent acceptance.";
RL   Am. J. Transplant. 7:1091-1102(2007).
CC   -!- FUNCTION: May regulate T-cell apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in peripheral blood leukocytes, mainly in
CC       T-lymphocytes. {ECO:0000269|PubMed:17456197}.
CC   -!- INDUCTION: Up-regulated during induction and maintenance of graft
CC       acceptance and down-regulated during graft rejection.
CC       {ECO:0000269|PubMed:17456197}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH473954; EDL76792.1; -; Genomic_DNA.
DR   RefSeq; NP_001104308.1; NM_001110838.1.
DR   AlphaFoldDB; P0DKR2; -.
DR   STRING; 10116.ENSRNOP00000005440; -.
DR   PaxDb; P0DKR2; -.
DR   PRIDE; P0DKR2; -.
DR   GeneID; 363169; -.
DR   KEGG; rno:363169; -.
DR   CTD; 285343; -.
DR   RGD; 1560717; Tcaim.
DR   VEuPathDB; HostDB:ENSRNOG00000004085; -.
DR   eggNOG; ENOG502QTGC; Eukaryota.
DR   HOGENOM; CLU_025230_0_0_1; -.
DR   InParanoid; P0DKR2; -.
DR   OMA; HISHYYS; -.
DR   OrthoDB; 849169at2759; -.
DR   PRO; PR:P0DKR2; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Proteomes; UP000234681; Chromosome 8.
DR   Bgee; ENSRNOG00000004085; Expressed in adult mammalian kidney and 18 other tissues.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   InterPro; IPR028031; DUF4460.
DR   InterPro; IPR027989; DUF4461.
DR   InterPro; IPR027986; TCAIM.
DR   PANTHER; PTHR31596; PTHR31596; 1.
DR   Pfam; PF14687; DUF4460; 1.
DR   Pfam; PF14688; DUF4461; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Mitochondrion; Reference proteome.
FT   CHAIN           1..505
FT                   /note="T-cell activation inhibitor, mitochondrial"
FT                   /id="PRO_0000420264"
FT   COILED          216..243
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   505 AA;  58413 MW;  66D2F443BB1ED51E CRC64;
     MLGSWRAFSE MFCHLRPWRR FCLRKVLPPW LHYSRALSGA EAINALRPFY FAVHPDFFGQ
     HPREREVNEN SLKRLSVYLE NLQKPGFKSL KPTQLTFYIR EKTAQNSSEG QEPVSTTGFR
     AVRFTLHSSD LLSTVLYILN SCSLPVEHVQ SLNTNVHSQP LKEATGMPDR PIKWHRSYYS
     FTGFKDPDED LEHVSRVETT LTSWLGSNGK GAVKKLKNSL PLRKELDRLK NELSELLQLS
     DIRWQRGWGV AHRCSQLHSL SRLAQQNLEP LQNAKGCTIV FTDRSGMSAL GHVMLGTMDV
     HHHWTRLFES LPNYFDLQRR MSALEDQISH LLGGIQVVYI EELQPALTLD EYYSLLDTFY
     NQLQRSRAPP RPQSLSGLQM ILSRYAPSLH ELGHFNIPAL SDPASLQSFM RTKAQQAREN
     MRRREKLKVI ENELIQASTR KFSLEKLYKE PSISSRQMVD CCKRLLEQSL PYLHGMHLCV
     SHFYSVMQDG DLCIPWNWKK GEAMK