TCAL2_HUMAN
ID TCAL2_HUMAN Reviewed; 227 AA.
AC Q9H3H9; B2R5C7;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Transcription elongation factor A protein-like 2;
DE Short=TCEA-like protein 2;
DE AltName: Full=Transcription elongation factor S-II protein-like 2;
GN Name=TCEAL2; ORFNames=My048, MY0876G0;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RA Mao Y., Xie Y., Tang R., Zhou Z., Huang Y., Zhao W., Wang W.;
RT "Isolation of full-length cDNA clones from human fetal brain cDNA
RT library.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Mao Y., Xie Y., Tang R., Zhou Z., Huang Y., Zhao W., Wang W.;
RT "Cloning and characterization of a novel human gene.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-68.
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR EMBL; AF063606; AAG43164.1; -; mRNA.
DR EMBL; AF325115; AAL37355.1; -; mRNA.
DR EMBL; AK312138; BAG35074.1; -; mRNA.
DR EMBL; AL035214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104764; AAI04765.1; -; mRNA.
DR EMBL; BC093932; AAH93932.1; -; mRNA.
DR CCDS; CCDS14496.1; -.
DR RefSeq; NP_525129.1; NM_080390.3.
DR AlphaFoldDB; Q9H3H9; -.
DR SMR; Q9H3H9; -.
DR BioGRID; 126630; 28.
DR IntAct; Q9H3H9; 13.
DR MINT; Q9H3H9; -.
DR STRING; 9606.ENSP00000361866; -.
DR iPTMnet; Q9H3H9; -.
DR PhosphoSitePlus; Q9H3H9; -.
DR BioMuta; TCEAL2; -.
DR DMDM; 74752614; -.
DR EPD; Q9H3H9; -.
DR jPOST; Q9H3H9; -.
DR MassIVE; Q9H3H9; -.
DR MaxQB; Q9H3H9; -.
DR PaxDb; Q9H3H9; -.
DR PeptideAtlas; Q9H3H9; -.
DR PRIDE; Q9H3H9; -.
DR ProteomicsDB; 80720; -.
DR Antibodypedia; 28844; 100 antibodies from 21 providers.
DR DNASU; 140597; -.
DR Ensembl; ENST00000329035.2; ENSP00000332359.2; ENSG00000184905.9.
DR Ensembl; ENST00000372780.6; ENSP00000361866.1; ENSG00000184905.9.
DR GeneID; 140597; -.
DR KEGG; hsa:140597; -.
DR MANE-Select; ENST00000372780.6; ENSP00000361866.1; NM_080390.4; NP_525129.1.
DR UCSC; uc004eip.4; human.
DR CTD; 140597; -.
DR GeneCards; TCEAL2; -.
DR HGNC; HGNC:29818; TCEAL2.
DR HPA; ENSG00000184905; Tissue enhanced (brain, pituitary gland).
DR neXtProt; NX_Q9H3H9; -.
DR OpenTargets; ENSG00000184905; -.
DR PharmGKB; PA134922072; -.
DR VEuPathDB; HostDB:ENSG00000184905; -.
DR eggNOG; ENOG502SXKH; Eukaryota.
DR GeneTree; ENSGT00950000183164; -.
DR HOGENOM; CLU_078412_1_0_1; -.
DR InParanoid; Q9H3H9; -.
DR OMA; QPPDEGK; -.
DR OrthoDB; 1366017at2759; -.
DR PhylomeDB; Q9H3H9; -.
DR TreeFam; TF336871; -.
DR PathwayCommons; Q9H3H9; -.
DR SignaLink; Q9H3H9; -.
DR BioGRID-ORCS; 140597; 9 hits in 693 CRISPR screens.
DR ChiTaRS; TCEAL2; human.
DR GenomeRNAi; 140597; -.
DR Pharos; Q9H3H9; Tdark.
DR PRO; PR:Q9H3H9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9H3H9; protein.
DR Bgee; ENSG00000184905; Expressed in endothelial cell and 175 other tissues.
DR Genevisible; Q9H3H9; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR InterPro; IPR021156; TF_A-like/BEX.
DR Pfam; PF04538; BEX; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..227
FT /note="Transcription elongation factor A protein-like 2"
FT /id="PRO_0000239206"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 19
FT /note="D -> G (in dbSNP:rs34924423)"
FT /id="VAR_034546"
FT VARIANT 68
FT /note="G -> A (in dbSNP:rs5944856)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034547"
SQ SEQUENCE 227 AA; 25850 MW; 32663547AA13FA63 CRC64;
MEKLFNENEG MPSNQGKIDN EEQPPHEGKP EVACILEDKK LENEGNTENT GKRVEEPLKD
KEKPESAGKA KGEGKSERKG KSEMQGGSKT EGKPERGGRA EGEGEPDSER EPESEGEPES
ETRAAGKRPA EDDIPRKAKR KTNKGLAQYL KQYKEAIHDM NFSNEDMIRE FDNMARVEDK
RRKSKQKLGA FLWMQRNLQD PFYPRGPREF RGGCRAPRRD TEDIPYV
