TCAL3_MOUSE
ID TCAL3_MOUSE Reviewed; 200 AA.
AC Q8R0A5; A2AEC3; Q9CYK5; Q9D1S4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transcription elongation factor A protein-like 3;
DE Short=TCEA-like protein 3;
DE AltName: Full=Transcription elongation factor S-II protein-like 3;
GN Name=Tceal3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR EMBL; AK003156; BAB22610.1; -; mRNA.
DR EMBL; AK017585; BAB30822.1; -; mRNA.
DR EMBL; AK158996; BAE34762.1; -; mRNA.
DR EMBL; AL671887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027131; AAH27131.1; -; mRNA.
DR CCDS; CCDS30420.1; -.
DR RefSeq; NP_001025149.2; NM_001029978.2.
DR RefSeq; XP_006528648.1; XM_006528585.3.
DR RefSeq; XP_006528649.1; XM_006528586.3.
DR RefSeq; XP_006528650.1; XM_006528587.1.
DR RefSeq; XP_011246054.1; XM_011247752.2.
DR AlphaFoldDB; Q8R0A5; -.
DR STRING; 10090.ENSMUSP00000059401; -.
DR iPTMnet; Q8R0A5; -.
DR PhosphoSitePlus; Q8R0A5; -.
DR MaxQB; Q8R0A5; -.
DR PaxDb; Q8R0A5; -.
DR PRIDE; Q8R0A5; -.
DR ProteomicsDB; 262960; -.
DR DNASU; 594844; -.
DR Ensembl; ENSMUST00000060904; ENSMUSP00000059401; ENSMUSG00000044550.
DR Ensembl; ENSMUST00000113100; ENSMUSP00000108724; ENSMUSG00000044550.
DR GeneID; 594844; -.
DR KEGG; mmu:594844; -.
DR UCSC; uc009uir.2; mouse.
DR CTD; 85012; -.
DR MGI; MGI:1913354; Tceal3.
DR VEuPathDB; HostDB:ENSMUSG00000044550; -.
DR eggNOG; ENOG502RKY0; Eukaryota.
DR GeneTree; ENSGT00950000183164; -.
DR HOGENOM; CLU_078412_1_0_1; -.
DR InParanoid; Q8R0A5; -.
DR OMA; NAQGKAN; -.
DR OrthoDB; 1432394at2759; -.
DR PhylomeDB; Q8R0A5; -.
DR TreeFam; TF336871; -.
DR BioGRID-ORCS; 594844; 0 hits in 40 CRISPR screens.
DR ChiTaRS; Tceal3; mouse.
DR PRO; PR:Q8R0A5; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8R0A5; protein.
DR Bgee; ENSMUSG00000044550; Expressed in dentate gyrus of hippocampal formation granule cell and 67 other tissues.
DR ExpressionAtlas; Q8R0A5; baseline and differential.
DR Genevisible; Q8R0A5; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR InterPro; IPR021156; TF_A-like/BEX.
DR Pfam; PF04538; BEX; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..200
FT /note="Transcription elongation factor A protein-like 3"
FT /id="PRO_0000239208"
FT REGION 1..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 170
FT /note="D -> Y (in Ref. 1; BAB22610)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="L -> P (in Ref. 3; AAH27131)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 22468 MW; 559365DA0F66A9A1 CRC64;
MEEVRGENEG KLEKEGKPED EVEPEDEEKS DEDEKPDKKA KPAPRQGKPE EEAKPDEQGQ
DEGKPEKQGK SDGEGKRQGE SKPDSQAKSA SEARAAEKRP AEDYVPRKAK RKTDRGTDDS
PKNSQEDLQD RHVSSEEMMR ECADMTRAQE ELRKRQKMGG FHWVPRDAQD ALVPRGPRGV
RGVRGGGGRS QRGLHDIPYL
