TCAL5_MOUSE
ID TCAL5_MOUSE Reviewed; 200 AA.
AC Q8CCT4; Q497R6;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transcription elongation factor A protein-like 5;
DE Short=TCEA-like protein 5;
DE AltName: Full=Transcription elongation factor S-II protein-like 5;
GN Name=Tceal5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR EMBL; AK032140; BAC27722.1; -; mRNA.
DR EMBL; BC100415; AAI00416.1; -; mRNA.
DR CCDS; CCDS30416.1; -.
DR RefSeq; NP_808587.1; NM_177919.2.
DR RefSeq; XP_006528639.1; XM_006528576.1.
DR AlphaFoldDB; Q8CCT4; -.
DR BioGRID; 237112; 1.
DR STRING; 10090.ENSMUSP00000065397; -.
DR iPTMnet; Q8CCT4; -.
DR PhosphoSitePlus; Q8CCT4; -.
DR UCD-2DPAGE; Q8CCT4; -.
DR MaxQB; Q8CCT4; -.
DR PaxDb; Q8CCT4; -.
DR PRIDE; Q8CCT4; -.
DR ProteomicsDB; 262961; -.
DR DNASU; 331532; -.
DR Ensembl; ENSMUST00000066819; ENSMUSP00000065397; ENSMUSG00000054034.
DR GeneID; 331532; -.
DR KEGG; mmu:331532; -.
DR UCSC; uc009uif.1; mouse.
DR CTD; 340543; -.
DR MGI; MGI:3036236; Tceal5.
DR VEuPathDB; HostDB:ENSMUSG00000054034; -.
DR eggNOG; ENOG502RKY0; Eukaryota.
DR GeneTree; ENSGT00950000183164; -.
DR HOGENOM; CLU_078412_1_0_1; -.
DR InParanoid; Q8CCT4; -.
DR OMA; CRENDGK; -.
DR OrthoDB; 1432394at2759; -.
DR PhylomeDB; Q8CCT4; -.
DR TreeFam; TF336871; -.
DR BioGRID-ORCS; 331532; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8CCT4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8CCT4; protein.
DR Bgee; ENSMUSG00000054034; Expressed in olfactory bulb and 56 other tissues.
DR ExpressionAtlas; Q8CCT4; baseline and differential.
DR Genevisible; Q8CCT4; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR InterPro; IPR021156; TF_A-like/BEX.
DR Pfam; PF04538; BEX; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..200
FT /note="Transcription elongation factor A protein-like 5"
FT /id="PRO_0000239212"
FT REGION 1..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 75
FT /note="G -> A (in Ref. 2; AAI00416)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 22038 MW; A843465710CE11F7 CRC64;
MEKFYKENEG KPENKGRAED EGSTEEGGKA DEDKSDAEGK PARQGKLEVE GGPGEQAQQK
GEGKPEKQGK SDGEGKRQGE SKPDSQAKSA SEARAAEKRP AEDYVPRKAK RKTDRGTDDS
PKNSQEDLQD RHVSSEEMMR ECADMTRAQE ELRKRQKMGG FHWVPRDAQD ALVPRGQRGV
RGVRGGGGRG QKDLEDAPFV
