TCAL6_HUMAN
ID TCAL6_HUMAN Reviewed; 200 AA.
AC Q6IPX3; Q5H9J8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transcription elongation factor A protein-like 6;
DE Short=TCEA-like protein 6;
DE AltName: Full=Transcription elongation factor S-II protein-like 6;
GN Name=TCEAL6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6IPX3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6IPX3-2; Sequence=VSP_019110;
CC -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z70719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071675; AAH71675.1; -; mRNA.
DR CCDS; CCDS43978.1; -. [Q6IPX3-2]
DR AlphaFoldDB; Q6IPX3; -.
DR IntAct; Q6IPX3; 1.
DR iPTMnet; Q6IPX3; -.
DR PhosphoSitePlus; Q6IPX3; -.
DR BioMuta; TCEAL6; -.
DR DMDM; 74736570; -.
DR EPD; Q6IPX3; -.
DR jPOST; Q6IPX3; -.
DR MassIVE; Q6IPX3; -.
DR MaxQB; Q6IPX3; -.
DR PaxDb; Q6IPX3; -.
DR PeptideAtlas; Q6IPX3; -.
DR PRIDE; Q6IPX3; -.
DR ProteomicsDB; 66466; -. [Q6IPX3-1]
DR ProteomicsDB; 66467; -. [Q6IPX3-2]
DR Antibodypedia; 28849; 128 antibodies from 18 providers.
DR Ensembl; ENST00000372773.2; ENSP00000361859.2; ENSG00000204071.11.
DR Ensembl; ENST00000372774.8; ENSP00000361860.4; ENSG00000204071.11.
DR UCSC; uc004eiq.4; human. [Q6IPX3-1]
DR GeneCards; TCEAL6; -.
DR HGNC; HGNC:24553; TCEAL6.
DR HPA; ENSG00000204071; Tissue enhanced (brain, pituitary gland, testis).
DR neXtProt; NX_Q6IPX3; -.
DR PharmGKB; PA142670828; -.
DR VEuPathDB; HostDB:ENSG00000204071; -.
DR InParanoid; Q6IPX3; -.
DR PhylomeDB; Q6IPX3; -.
DR TreeFam; TF336871; -.
DR PathwayCommons; Q6IPX3; -.
DR SignaLink; Q6IPX3; -.
DR Pharos; Q6IPX3; Tdark.
DR PRO; PR:Q6IPX3; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6IPX3; protein.
DR Bgee; ENSG00000204071; Expressed in superior frontal gyrus and 88 other tissues.
DR ExpressionAtlas; Q6IPX3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR InterPro; IPR021156; TF_A-like/BEX.
DR Pfam; PF04538; BEX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..200
FT /note="Transcription elongation factor A protein-like 6"
FT /id="PRO_0000239213"
FT REGION 1..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q969E4"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q969E4"
FT VAR_SEQ 175..200
FT /note="PRGQRGVRGVRGGGRGQRGLHDIPYL -> QGDNGVSGE (in isoform
FT 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_019110"
SQ SEQUENCE 200 AA; 22298 MW; 05D8DA7EDE49DB86 CRC64;
MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDAEG KTECEGKRKA EGEPGDEGQL
EDKGSQEKQG KSEGEGKPQG EGKPASQAKP EGQPRAAEKR PAGDYVPRKA KRKTDRGTDD
SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG
VRGVRGGGRG QRGLHDIPYL
