TCAL7_HUMAN
ID TCAL7_HUMAN Reviewed; 100 AA.
AC Q9BRU2; B3KSV2; Q96AT4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Transcription elongation factor A protein-like 7;
DE Short=TCEA-like protein 7;
DE AltName: Full=Transcription elongation factor S-II protein-like 7;
GN Name=TCEAL7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=18806825; DOI=10.1038/onc.2008.360;
RA Chien J., Narita K., Rattan R., Giri S., Shridhar R., Staub J.,
RA Beleford D., Lai J., Roberts L.R., Molina J., Kaufmann S.H.,
RA Prendergast G.C., Shridhar V.;
RT "A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-
RT Myc activity, cyclin D1 levels and cellular transformation.";
RL Oncogene 27:7223-7234(2008).
RN [6]
RP FUNCTION.
RX PubMed=20454512; DOI=10.1593/neo.10180;
RA Lafferty-Whyte K., Bilsland A., Hoare S.F., Burns S., Zaffaroni N.,
RA Cairney C.J., Keith W.N.;
RT "TCEAL7 inhibition of c-Myc activity in alternative lengthening of
RT telomeres regulates hTERT expression.";
RL Neoplasia 12:405-414(2010).
RN [7]
RP FUNCTION.
RX PubMed=19966855; DOI=10.1038/onc.2009.431;
RA Rattan R., Narita K., Chien J., Maguire J.L., Shridhar R., Giri S.,
RA Shridhar V.;
RT "TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB
RT pathway.";
RL Oncogene 29:1362-1373(2010).
CC -!- FUNCTION: Plays a role in the negative regulation of NF-kappa-B
CC signaling at the basal level by modulating transcriptional activity of
CC NF-kappa-B on its target gene promoters. Associates with cyclin D1
CC promoter containing Myc E-box sequence and transcriptionally represses
CC cyclin D1 expression. Regulates telomerase reverse transcriptase
CC expression and telomerase activity in both ALT (alternative lengthening
CC of telomeres)and telomerase-positive cell lines.
CC {ECO:0000269|PubMed:18806825, ECO:0000269|PubMed:19966855,
CC ECO:0000269|PubMed:20454512}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18806825}.
CC -!- TISSUE SPECIFICITY: Highly expressed in normal and fetal brain tissues,
CC and weakly expressed in uterus and ovary. Down-regulated in epithelial
CC ovarian, cervical, prostate, breast, brain and lung cancer cell lines
CC and in brain and ovarian tumors. {ECO:0000269|PubMed:18806825}.
CC -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR EMBL; AK094400; BAG52864.1; -; mRNA.
DR EMBL; Z92846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471190; EAW54714.1; -; Genomic_DNA.
DR EMBL; BC005988; AAH05988.2; -; mRNA.
DR EMBL; BC016786; AAH16786.1; -; mRNA.
DR CCDS; CCDS14506.1; -.
DR RefSeq; NP_001335187.1; NM_001348258.1.
DR RefSeq; NP_689491.1; NM_152278.4.
DR AlphaFoldDB; Q9BRU2; -.
DR SMR; Q9BRU2; -.
DR BioGRID; 121209; 107.
DR IntAct; Q9BRU2; 2.
DR MINT; Q9BRU2; -.
DR STRING; 9606.ENSP00000329794; -.
DR BioMuta; TCEAL7; -.
DR DMDM; 74761221; -.
DR MassIVE; Q9BRU2; -.
DR MaxQB; Q9BRU2; -.
DR PaxDb; Q9BRU2; -.
DR PeptideAtlas; Q9BRU2; -.
DR PRIDE; Q9BRU2; -.
DR ProteomicsDB; 78837; -.
DR Antibodypedia; 44282; 78 antibodies from 21 providers.
DR DNASU; 56849; -.
DR Ensembl; ENST00000332431.5; ENSP00000329794.4; ENSG00000182916.8.
DR Ensembl; ENST00000372666.1; ENSP00000361751.1; ENSG00000182916.8.
DR GeneID; 56849; -.
DR KEGG; hsa:56849; -.
DR MANE-Select; ENST00000332431.5; ENSP00000329794.4; NM_152278.5; NP_689491.1.
DR UCSC; uc004ekc.3; human.
DR CTD; 56849; -.
DR DisGeNET; 56849; -.
DR GeneCards; TCEAL7; -.
DR HGNC; HGNC:28336; TCEAL7.
DR HPA; ENSG00000182916; Tissue enhanced (brain).
DR MIM; 300771; gene.
DR neXtProt; NX_Q9BRU2; -.
DR OpenTargets; ENSG00000182916; -.
DR PharmGKB; PA134936264; -.
DR VEuPathDB; HostDB:ENSG00000182916; -.
DR eggNOG; ENOG502TCAG; Eukaryota.
DR GeneTree; ENSGT00950000183164; -.
DR HOGENOM; CLU_181913_0_0_1; -.
DR InParanoid; Q9BRU2; -.
DR OMA; DYRHFKG; -.
DR OrthoDB; 1572049at2759; -.
DR PhylomeDB; Q9BRU2; -.
DR PathwayCommons; Q9BRU2; -.
DR SignaLink; Q9BRU2; -.
DR BioGRID-ORCS; 56849; 112 hits in 685 CRISPR screens.
DR GenomeRNAi; 56849; -.
DR Pharos; Q9BRU2; Tbio.
DR PRO; PR:Q9BRU2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9BRU2; protein.
DR Bgee; ENSG00000182916; Expressed in Brodmann (1909) area 46 and 153 other tissues.
DR Genevisible; Q9BRU2; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR InterPro; IPR021156; TF_A-like/BEX.
DR Pfam; PF04538; BEX; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..100
FT /note="Transcription elongation factor A protein-like 7"
FT /id="PRO_0000239214"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..88
FT /evidence="ECO:0000255"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 100 AA; 12324 MW; 84AF23BD169606D0 CRC64;
MQKPCKENEG KPKCSVPKRE EKRPYGEFER QQTEGNFRQR LLQSLEEFKE DIDYRHFKDE
EMTREGDEME RCLEEIRGLR KKFRALHSNH RHSRDRPYPI
