ID   TCAL7_MOUSE             Reviewed;          98 AA.
AC   A3KGA4;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Transcription elongation factor A protein-like 7;
DE            Short=TCEA-like protein 7;
DE   AltName: Full=Transcription elongation factor S-II protein-like 7;
GN   Name=Tceal7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Plays a role in the negative regulation of NF-kappa-B
CC       signaling at the basal level by modulating transcriptional activity of
CC       NF-kappa-B on its target gene promoters. Associates with cyclin D1
CC       promoter containing Myc E-box sequence and transcriptionally represses
CC       cyclin D1 expression. Regulates telomerase reverse transcriptase
CC       expression and telomerase activity in both ALT (alternative lengthening
CC       of telomeres)and telomerase-positive cell lines (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR   EMBL; AL671493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53193.1; -.
DR   RefSeq; NP_001120641.1; NM_001127169.1.
DR   RefSeq; XP_006528530.1; XM_006528467.2.
DR   AlphaFoldDB; A3KGA4; -.
DR   SMR; A3KGA4; -.
DR   STRING; 10090.ENSMUSP00000108741; -.
DR   PaxDb; A3KGA4; -.
DR   PRIDE; A3KGA4; -.
DR   Antibodypedia; 44282; 78 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000113116; ENSMUSP00000108741; ENSMUSG00000079428.
DR   GeneID; 100040972; -.
DR   KEGG; mmu:100040972; -.
DR   UCSC; uc009uih.2; mouse.
DR   CTD; 56849; -.
DR   MGI; MGI:1915746; Tceal7.
DR   VEuPathDB; HostDB:ENSMUSG00000079428; -.
DR   eggNOG; ENOG502TCAG; Eukaryota.
DR   GeneTree; ENSGT00950000183164; -.
DR   HOGENOM; CLU_181913_0_0_1; -.
DR   InParanoid; A3KGA4; -.
DR   OMA; DYRHFKG; -.
DR   OrthoDB; 1572049at2759; -.
DR   PhylomeDB; A3KGA4; -.
DR   BioGRID-ORCS; 100040972; 0 hits in 69 CRISPR screens.
DR   PRO; PR:A3KGA4; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; A3KGA4; protein.
DR   Bgee; ENSMUSG00000079428; Expressed in late embryo and 92 other tissues.
DR   ExpressionAtlas; A3KGA4; baseline and differential.
DR   Genevisible; A3KGA4; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   Pfam; PF04538; BEX; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..98
FT                   /note="Transcription elongation factor A protein-like 7"
FT                   /id="PRO_0000404650"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          59..89
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   98 AA;  11697 MW;  99437BEE0A59652F CRC64;
     MQKSCNEKEG KPKGSEAKRE DEQPCGALEG QRLEGNFRQR LLQSLEEFKE DIDYRHFKGE
     EMTGEEEEME RCLEEIRSLR KKFRALHSNR THSRDHPF