ID   TCAL7_RAT               Reviewed;          98 AA.
AC   D3ZT37;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Transcription elongation factor A protein-like 7;
DE            Short=TCEA-like protein 7;
DE   AltName: Full=Transcription elongation factor S-II protein-like 7;
GN   Name=Tceal7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the negative regulation of NF-kappa-B
CC       signaling at the basal level by modulating transcriptional activity of
CC       NF-kappa-B on its target gene promoters. Associates with cyclin D1
CC       promoter containing Myc E-box sequence and transcriptionally represses
CC       cyclin D1 expression. Regulates telomerase reverse transcriptase
CC       expression and telomerase activity in both ALT (alternative lengthening
CC       of telomeres)and telomerase-positive cell lines (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR   EMBL; CH474117; EDL85806.1; -; Genomic_DNA.
DR   RefSeq; NP_001102871.1; NM_001109401.1.
DR   RefSeq; XP_006257341.1; XM_006257279.3.
DR   RefSeq; XP_006257342.1; XM_006257280.3.
DR   RefSeq; XP_008771659.1; XM_008773437.2.
DR   AlphaFoldDB; D3ZT37; -.
DR   SMR; D3ZT37; -.
DR   STRING; 10116.ENSRNOP00000042856; -.
DR   PaxDb; D3ZT37; -.
DR   PRIDE; D3ZT37; -.
DR   Ensembl; ENSRNOT00000046091; ENSRNOP00000042856; ENSRNOG00000037645.
DR   GeneID; 680319; -.
DR   KEGG; rno:680319; -.
DR   CTD; 56849; -.
DR   RGD; 1593009; Tceal7.
DR   eggNOG; ENOG502TCAG; Eukaryota.
DR   GeneTree; ENSGT00950000183164; -.
DR   HOGENOM; CLU_181913_0_0_1; -.
DR   InParanoid; D3ZT37; -.
DR   OMA; DYRHFKG; -.
DR   OrthoDB; 1572049at2759; -.
DR   PhylomeDB; D3ZT37; -.
DR   PRO; PR:D3ZT37; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Proteomes; UP000234681; Chromosome x.
DR   Bgee; ENSRNOG00000037645; Expressed in quadriceps femoris and 8 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   Pfam; PF04538; BEX; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..98
FT                   /note="Transcription elongation factor A protein-like 7"
FT                   /id="PRO_0000404651"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          59..89
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   98 AA;  11933 MW;  BD43F74979C54309 CRC64;
     MQRSCNEKEG KPKCSEPKRE EEHPYGAFEG QRLEGNFRQR LLQSLEEFKE DIDYRHFKGE
     EMTGEEEEME RCLEEIRSLR KKFRALHSNR THSRDRPF