ID   TCAL8_HUMAN             Reviewed;         117 AA.
AC   Q8IYN2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Transcription elongation factor A protein-like 8;
DE            Short=TCEA-like protein 8;
DE   AltName: Full=Transcription elongation factor S-II protein-like 8;
GN   Name=TCEAL8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q8IYN2; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-2116184, EBI-1104933;
CC       Q8IYN2; Q9NNX6-10: CD209; NbExp=3; IntAct=EBI-2116184, EBI-12300031;
CC       Q8IYN2; Q8N668: COMMD1; NbExp=3; IntAct=EBI-2116184, EBI-1550112;
CC       Q8IYN2; P28799: GRN; NbExp=3; IntAct=EBI-2116184, EBI-747754;
CC       Q8IYN2; P04792: HSPB1; NbExp=3; IntAct=EBI-2116184, EBI-352682;
CC       Q8IYN2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-2116184, EBI-10975473;
CC       Q8IYN2; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-2116184, EBI-396669;
CC       Q8IYN2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2116184, EBI-5235340;
CC       Q8IYN2; O76024: WFS1; NbExp=3; IntAct=EBI-2116184, EBI-720609;
CC       Q8IYN2; P54577: YARS1; NbExp=3; IntAct=EBI-2116184, EBI-1048893;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR   EMBL; BC035573; AAH35573.1; -; mRNA.
DR   EMBL; Z68694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS14504.1; -.
DR   RefSeq; NP_001006685.1; NM_001006684.1.
DR   RefSeq; NP_699164.1; NM_153333.2.
DR   AlphaFoldDB; Q8IYN2; -.
DR   BioGRID; 124770; 16.
DR   IntAct; Q8IYN2; 11.
DR   STRING; 9606.ENSP00000361770; -.
DR   iPTMnet; Q8IYN2; -.
DR   PhosphoSitePlus; Q8IYN2; -.
DR   BioMuta; TCEAL8; -.
DR   DMDM; 74762496; -.
DR   EPD; Q8IYN2; -.
DR   MassIVE; Q8IYN2; -.
DR   MaxQB; Q8IYN2; -.
DR   PaxDb; Q8IYN2; -.
DR   PeptideAtlas; Q8IYN2; -.
DR   PRIDE; Q8IYN2; -.
DR   ProteomicsDB; 71208; -.
DR   Antibodypedia; 55458; 89 antibodies from 22 providers.
DR   DNASU; 90843; -.
DR   Ensembl; ENST00000360000.8; ENSP00000353093.4; ENSG00000180964.17.
DR   Ensembl; ENST00000372685.8; ENSP00000361770.3; ENSG00000180964.17.
DR   GeneID; 90843; -.
DR   KEGG; hsa:90843; -.
DR   MANE-Select; ENST00000372685.8; ENSP00000361770.3; NM_153333.3; NP_699164.1.
DR   UCSC; uc004ejx.4; human.
DR   CTD; 90843; -.
DR   GeneCards; TCEAL8; -.
DR   HGNC; HGNC:28683; TCEAL8.
DR   HPA; ENSG00000180964; Low tissue specificity.
DR   neXtProt; NX_Q8IYN2; -.
DR   OpenTargets; ENSG00000180964; -.
DR   PharmGKB; PA134991274; -.
DR   VEuPathDB; HostDB:ENSG00000180964; -.
DR   eggNOG; ENOG502R12B; Eukaryota.
DR   GeneTree; ENSGT00950000183164; -.
DR   HOGENOM; CLU_181913_0_0_1; -.
DR   InParanoid; Q8IYN2; -.
DR   OMA; CEENEGN; -.
DR   OrthoDB; 1497581at2759; -.
DR   PhylomeDB; Q8IYN2; -.
DR   TreeFam; TF336871; -.
DR   PathwayCommons; Q8IYN2; -.
DR   SignaLink; Q8IYN2; -.
DR   BioGRID-ORCS; 90843; 8 hits in 702 CRISPR screens.
DR   GenomeRNAi; 90843; -.
DR   Pharos; Q8IYN2; Tdark.
DR   PRO; PR:Q8IYN2; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q8IYN2; protein.
DR   Bgee; ENSG00000180964; Expressed in calcaneal tendon and 177 other tissues.
DR   ExpressionAtlas; Q8IYN2; baseline and differential.
DR   Genevisible; Q8IYN2; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR   InterPro; IPR021156; TF_A-like/BEX.
DR   Pfam; PF04538; BEX; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..117
FT                   /note="Transcription elongation factor A protein-like 8"
FT                   /id="PRO_0000239216"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          73..100
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  13616 MW;  8BCFC0CAC699C7A5 CRC64;
     MQKSCEENEG KPQNMPKAEE DRPLEDVPQE AEGNPQPSEE GVSQEAEGNP RGGPNQPGQG
     FKEDTPVRHL DPEEMIRGVD ELERLREEIR RVRNKFVMMH WKQRHSRSRP YPVCFRP