TCAL8_MOUSE
ID TCAL8_MOUSE Reviewed; 117 AA.
AC Q9CZY2; A2AJR7; Q9CYP9;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Transcription elongation factor A protein-like 8;
DE Short=TCEA-like protein 8;
DE AltName: Full=Transcription elongation factor S-II protein-like 8;
GN Name=Tceal8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TFS-II family. TFA subfamily. {ECO:0000305}.
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DR EMBL; AK012030; BAB27984.1; -; mRNA.
DR EMBL; AK014459; BAB29366.1; -; mRNA.
DR EMBL; AK137039; BAE23212.1; -; mRNA.
DR EMBL; AK156414; BAE33705.1; -; mRNA.
DR EMBL; AL772180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027269; AAH27269.1; -; mRNA.
DR CCDS; CCDS30415.1; -.
DR RefSeq; NP_001162050.1; NM_001168578.1.
DR RefSeq; NP_079979.2; NM_025703.3.
DR AlphaFoldDB; Q9CZY2; -.
DR BioGRID; 211644; 1.
DR STRING; 10090.ENSMUSP00000056189; -.
DR PhosphoSitePlus; Q9CZY2; -.
DR MaxQB; Q9CZY2; -.
DR PaxDb; Q9CZY2; -.
DR PRIDE; Q9CZY2; -.
DR ProteomicsDB; 263142; -.
DR Antibodypedia; 55458; 89 antibodies from 22 providers.
DR DNASU; 66684; -.
DR Ensembl; ENSMUST00000060101; ENSMUSP00000056189; ENSMUSG00000051579.
DR Ensembl; ENSMUST00000163584; ENSMUSP00000129591; ENSMUSG00000051579.
DR GeneID; 66684; -.
DR KEGG; mmu:66684; -.
DR UCSC; uc009uie.2; mouse.
DR CTD; 90843; -.
DR MGI; MGI:1913934; Tceal8.
DR VEuPathDB; HostDB:ENSMUSG00000051579; -.
DR eggNOG; ENOG502R12B; Eukaryota.
DR GeneTree; ENSGT00950000183164; -.
DR HOGENOM; CLU_181913_0_0_1; -.
DR InParanoid; Q9CZY2; -.
DR OMA; CEENEGN; -.
DR OrthoDB; 1497581at2759; -.
DR PhylomeDB; Q9CZY2; -.
DR BioGRID-ORCS; 66684; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tceal8; mouse.
DR PRO; PR:Q9CZY2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9CZY2; protein.
DR Bgee; ENSMUSG00000051579; Expressed in atrioventricular valve and 243 other tissues.
DR ExpressionAtlas; Q9CZY2; baseline and differential.
DR Genevisible; Q9CZY2; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR InterPro; IPR021156; TF_A-like/BEX.
DR Pfam; PF04538; BEX; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..117
FT /note="Transcription elongation factor A protein-like 8"
FT /id="PRO_0000239217"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..100
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 111
FT /note="Y -> S (in Ref. 1; BAB29366)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 117 AA; 13472 MW; 16245D8D6006CA22 CRC64;
MQKSCDENEG TPQNTPKADE GHPSEDPPQQ AGETLQASGE NVREETEGSH RGEPAEPSPE
PKEDTPARHL NPEEVIRGVD ELERLREEIR RVRNKFVLMH WKQRHSRSRP YPVCFRP
